Mikael Sigvardsson
Titel
Professor
Organisation
Mikael [dot] Sigvardsson [at] med [dot] lu [dot] se
Publikationer (hämtat ur Lunds universitets publikationsdatabas)
författare
- 2013
- 2012
- 2011
- 2010
- Epigenetic chromatin states uniquely define the developmental plasticity of murine hematopoietic stem cells.
- Genomics based analysis of interactions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication
- Load and lock: the molecular mechanisms of B-lymphocyte commitment.
- Nuclear Factor of Activated T Cells Regulates Osteopontin Expression in Arterial Smooth Muscle in Response to Diabetes-Induced Hyperglycemia.
- Shaping up a lineage-lessons from B lymphopoesis.
- Single cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity.
- 2008
- B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells
- Deciphering developmental stages of adult myelopoiesis.
- EBF1 is essential for B-Lineage priming and establishment of a transcription factor network in common lymphoid progenitors
- Exit of pediatric pre-B acute lymphoblastic leukaemia cells from the bone marrow to the peripheral blood is not associated with cell maturation or alterations in gene expression.
- Molecular profiling reveals distinct functional attributes of CD1d-restricted natural killer (NK) T cell subsets
- Permissive roles of hematopoietin and cytokine tyrosine kinase receptors in early T cell development
- 2007
- A critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade.
- Critical role of FLT3 ligand in IL-7 receptor-independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors
- Ectopic expression of PAX5 promotes self renewal of bi-phenotypic myeloid progenitors co-expressing myeloid and B-cell lineage associated genes.
- Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy
- HOXA10 is a critical regulator for hematopoietic stem cells and erythroid/megakaryocyte development.
- Loss of bHLH transcription factor E2A activity in primary effusion lymphoma confers resistance to apoptosis
- Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon.
- Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors.
- The CD53 and CEACAM-1 genes are genetic targets for early B cell factor.
- The CXCL12, periostin and CCL9 genes are direct targets for early B-cell factor (EBF) in OP-9 stroma cells.
- The molecular signature of MDS stem cells supports a stem-cell origin of 5q - myelodysplastic syndromes
- 2006
- Functional characterization of the CCL25 promoter in small intestinal epithelial cells suggests a regulatory role for caudal-related homeobox (Cdx) transcription factors
- Immune status and inflammatory response differ locally and systemically in severe acute pancreatitis.
- Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma
- 2005
- Gene expression analysis suggests that EBF-1 and PPAR gamma 2 induce adipogenesis of NIH-3T3 cells with similar efficiency and kinetics
- Identification of Flt3(+) lympho-myeloid stem cells lacking erythro-megakaryocytic potential: A revised road map for adult blood lineage commitment
- Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment
- Identification of Lin-Sca1+kit+CD34+Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated recipients.
- Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development
- Predictive screening for regulators of conserved functional gene modules (gene batteries) in mammals
- 2004
- CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/ref-1-dependent redox mechanism
- Induction of ID2 expression by hypoxia-inducible factor-1: ARole in dedifferentiation of hypoxic neuroblastoma cells.
- Neuroblastoma and pre-B lymphoma cells share expression of key transcription factors but display tissue restricted target gene expression
- Olf/EBF proteins are expressed in neuroblastoma cells: potential regulators of the Chromogranin A and SCG10 promoters.
- Pearson correlation analysis of micro-array data allows for the identification of genetic targets for early B-cell factor.
- The roles of transcription factors in B lymphocyte commitment, development, and transformation.
- 2003
- Complementary Signaling through flt3 and Interleukin-7 Receptor {alpha} Is Indispensable for Fetal and Adult B Cell Genesis.
- Inhibition of p300/CBP by early B-cell factor
- Probabilistic estimation of microarray data reliability and underlying gene expression
- RNA analysis of B cell lines arrested at defined stages of differentiation allows for an approximation of gene expression patterns during B cell development.
- 2002
- Cloning and characterization of a promoter flanking the early B cell factor (EBF) gene indicates roles for E-proteins and autoregulation in the control of EBF expression.
- Early B-Cell Factor, E2A, and Pax-5 Cooperate To Activate the Early B Cell-Specific mb-1 Promoter.
- Early B-cell factor (o/e-1) is a promoter of adipogenesis and involved in control of genes important for terminal adipocyte differentiation.
- The EBF/Olf/Collier Family of Transcription Factors: Regulators of Differentiation in Cells Originating from All Three Embryonal Germ Layers.
- The human V-preB promoter is a target for coordinated activation by early B cell factor and E47.
- The pTalpha promoter and enhancer are direct targets for transactivation by E box-binding proteins.
