Deniz Kirik
Titel
professor
Organisation
046-2220564
+46733822586
Deniz [dot] Kirik [at] med [dot] lu [dot] se
Publikationer (hämtat ur Lunds universitets publikationsdatabas)
författare
- 2013
- 2012
- Altered profile of basket cell afferent synapses in hyper-excitable dentate gyrus revealed by optogenetic and two-pathway stimulations.
- Characterization of a rat model of Huntington's disease based on targeted expression of mutant huntingtin in the forebrain using adeno-associated viral vectors.
- Design of a Single AAV Vector for Coexpression of TH and GCH1 to Establish Continuous DOPA Synthesis in a Rat Model of Parkinson's Disease.
- Development and characterisation of a novel rat model of Parkinson's disease induced by sequential intranigral administration of AAV-α-synuclein and the pesticide, rotenone.
- Development of NMR spectroscopic methods for dynamic detection of acetylcholine synthesis by choline acetyltransferase in hippocampal tissue.
- Dysregulated dopamine storage increases the vulnerability to alpha-synuclein in nigral neurons
- GIRK2 Expression in Dopamine Neurons of the Substantia Nigra and Ventral Tegmental Area
- Key factors determining the efficacy of gene therapy for continuous DOPA delivery in the Parkinsonian brain
- Long-term polarization of microglia upon α-synuclein overexpression in nonhuman primates
- Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system
- Special Issue: Viral delivery of genes: new frontiers Introduction
- alpha-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease
- 2011
- GDNF fails to exert neuroprotection in a rat {alpha}-synuclein model of Parkinson's disease.
- Imaging of Brain Prion Protein Amyloid in Patients with Gertstmann-Straussler-Scheinker Disease
- Magnetic Resonance Spectroscopic Methods for the Assessment of Metabolic Functions in the Diseased Brain.
- Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits.
- Systemic Rotenone Does Not Enhance Parkinsonian Pathology Caused By Intracerebral Alpha-Synuclein In Rats
- 2010
- A General Chemical Method to Regulate Protein Stability in the Mammalian Central Nervous System
- Adeno-associated viral vector serotypes 1 and 5 targeted to the neonatal rat and pig striatum induce widespread transgene expression in the forebrain
- CELL THERAPY FOR PARKINSON'S DISEASE: PERSPECTIVES ON THE CLINICAL EXPERIENCE
- Changes in key hypothalamic neuropeptide populations in Huntington disease revealed by neuropathological analyses.
- Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology.
- Differential Transduction Following Basal Ganglia Administration of Distinct Pseudotyped AAV Capsid Serotypes in Nonhuman Primates
- Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis.
- Feasibility of in vivo N-15 MRS detection of hyperpolarized N-15 labeled choline in rats
- Gene Therapy
- Gene therapy for dopamine replacement.
- Glial Cell Derived Neurotrophic Factor Does not Provide Neuroprotection Against Alpha-Synuclein-Induced Toxicity in a Rat Model of Parkinson's Disease
- Microglia Acquire Distinct Activation Profiles Depending on the Degree of alpha-Synuclein Neuropathology in a rAAV Based Model of Parkinson's Disease
- Optimized adeno-associated viral vector-mediated striatal DOPA delivery restores sensorimotor function and prevents dyskinesias in a model of advanced Parkinson's disease.
- Presynaptic dopaminergic compartment determines the susceptibility to L-DOPA-induced dyskinesia in rats.
- Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease.
- The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson's disease
- Viral vector-mediated overexpression of alpha-synuclein as a progressive model of Parkinson's disease
- Viral vector-mediated overexpression of α-synuclein as a progressive model of Parkinson's disease.
- 2009
- Are the animal models of Parkinson's disease suitable for development of neuroprotective therapies?
- Differential Infectivity Following Basal Ganglia Administration of Differing AAV Serotypes in Nonhuman Primates
- Dose Optimization for Long-term rAAV-mediated RNA Interference in the Nigrostriatal Projection Neurons.
- Gene therapy for dopamine replacement in Parkinson's disease.
- Huntington's Disease - New Perspectives Based on Neuroendocrine Changes in Rodent Models.
- Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration.
- Optimization of continuous in vivo DOPA production and studies of ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats.
- Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats
- Positron Emission Tomography Imaging Demonstrates Correlation between Behavioral Recovery and Correction of Dopamine Neurotransmission after Gene Therapy
- Proton NMR of (15)N-Choline Metabolites Enhanced by Dynamic Nuclear Polarization.
- Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain.
- Scientific rationale for the development of gene therapy strategies for Parkinson's disease.
- Serotonin neuron-dependent and -independent reduction of dyskinesia by 5-HT(1A) and 5-HT(1B) receptor agonists in the rat Parkinson model.
- Suppression of Map Kinases Inhibits Microglial Activation and Attenuates Neuronal Cell Death Induced by Alpha-Synuclein Protofibrils
- 2008
- Applications of lentiviral vectors for biology and gene therapy of neurological disorders.
- Can overexpression of parkin provide a novel strategy for neuroprotection in Parkinson's disease?
- Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia.
- Functional convergence of dopaminergic and cholinergic input is critical for hippocampus-dependent working memory.
- Future Cell- and Gene-Based Therapies for Parkinson's Disease
- In vivo gene delivery for development of mammalian models for Parkinson's disease
- In vivo gene delivery to proliferating cells in the striatum generated in response to a 6-hydroxydopamine lesion of the nigro-striatal dopamine pathway
- Is alpha-synuclein the culprit of the Parkinsonian neurodegeneration?
- Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.
- Non-dopaminergic neurons in ventral mesencephalic transplants make widespread axonal connections in the host brain.
- Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias.
- 2007
- Brain area, age and viral vector-specific glial cell-line-derived neurotrophic factor expression and transport in rat.
- Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats.
- Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain.
- Murine models of acute neuronopathic Gaucher disease
- Restoration of the striatal dopamine synthesis for Parkinson's disease: viral vector-mediated enzyme replacement strategy.
- Seizure Suppression by GDNF Gene Therapy in Animal Models of Epilepsy.
- Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease
- The functional impact of the intrastriatal dopamine neuron grafts in parkinsonian rats is reduced with advancing disease
- 2006
- An investigation of the problem of two-layered immunohistochemical staining in paraformaldehyde fixed sections
- Continuous exposure to glial cell line-derived neurotrophic factor to mature dopaminergic transplants impairs the graft's ability to improve spontaneous motor behavior in parkinsonian rats.
- Graft placement and uneven pattern of reinnervation in the striatum is important for development of graft-induced dyskinesia.
- Targeted in utero delivery of a retroviral vector for gene transfer in the rodent brain.
- Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression.
- 2005
- Cell transplantation in Parkinson's disease: how can we make it work?
- Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease
- Functional properties and synaptic integration of genetically labelled dopaminergic neurons in intrastriatal grafts.
- Histological analysis of fetal dopamine cell suspension grafts in two patients with Parkinson's disease gives promising results
- Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections.
- Imaging in cell-based therapy for neurodegenerative diseases.
- Isolation and characterization of neural precursor cells from the Sox1-GFP reporter mouse.
- Lentiviral gene delivery of GDNF into the striatum of R6/2 Huntington mice fails to attenuate behavioral and neuropathological changes.
- Parkinson's disease: Viral vector delivery of parkin generates model results in rats.
- Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors.
- Viral Vector Mediated Overexpression of Human alpha-Synuclein in the Nigrostriatal Dopaminergic Neurons: A New Model for Parkinson's Disease.
- 2004
- Dissociation between short-term increased graft survival and long-term functional improvements in Parkinsonian rats overexpressing glial cell line-derived neurotrophic factor.
- Localized striatal delivery of GDNF as a treatment for Parkinson disease.
- Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system.
- Regulated delivery of glial cell line-derived neurotrophic factor into rat striatum, using a tetracycline-dependent lentiviral vector.
- 2003
- Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke.
- Elevated GDNF levels following viral vector-mediated gene transfer can increase neuronal death after stroke in rats.
- Long-term striatal overexpression of GDNF selectively downregulates tyrosine hydroxylase in the intact nigrostriatal dopamine system.
- Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors.
- Nigrostriatal {alpha}-synucleinopathy induced by viral vector-mediated overexpression of human {alpha}-synuclein: A new primate model of Parkinson's disease.
- Recombinant adeno-associated viral vector (rAAV) delivery of GDNF provides protection against 6-OHDA lesion in the common marmoset monkey (Callithrix jacchus)
- 2002
- Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer.
- L-DOPA-Induced Dyskinesia in the Intrastriatal 6-Hydroxydopamine Model of Parkinson's Disease: Relation to Motor and Cellular Parameters of Nigrostriatal Function.
- Neuronal replacement from endogenous precursors in the adult brain after stroke.
- Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using a lentiviral vector.
- Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system
- Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.
- Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease.
- Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer.
- 2001
- Delayed infusion of GDNF promotes recovery of motor function in the partial lesion model of Parkinson's disease
- Growth and functional efficacy of intrastriatal nigral transplants depend on the extent of nigrostriatal degeneration
- Restorative and neuroprotective treatment strategies for Parkinson’s disease: tudies on fetal dopamine cell transplants and GDNF delivery by intracerebral injections and recombinant AAV vectors.
- 2000
- EGF infusion stimulates the proliferation and migration of embryonic progenitor cells transplanted in the adult rat striatum
- European neuroscience meets the snow
- In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin
- Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system
- Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor
- Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model
- Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model
- Transplantation in the rat model of Parkinson's disease: ectopic versus homotopic graft placement
- 1999
- 1998
- 1997
