Björn Dahlbäck
Titel
Professor, Avdelningschef
Organisation
+4640331501
Bjorn [dot] Dahlback [at] med [dot] lu [dot] se
Publikationer (hämtat ur Lunds universitets publikationsdatabas)
författare
- 2012
- Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL
- Biocompatibility of mannan nanogel-safe interaction with plasma proteins
- Coagulation and inflammation-close allies in health and disease.
- Decreased plasma concentrations of apolipoprotein M in sepsis and systemic inflammatory response syndromes
- Polystyrene nanoparticles affecting blood coagulation.
- Polystyrene nanoparticles affecting blood coagulation.
- Small and large PROS1 deletions but no other types of rearrangements detected in patents with protein S deficiency
- The plasma concentration of HDL-associated apoM is influenced by LDL receptor-mediated clearance of apoB-containing particles
- 2011
- Activated protein C cofactor function of protein S: a novel role for a gamma-carboxyglutamic acid residue
- C4b-Binding Protein: A Forgotten Factor in Thrombosis and Hemostasis
- C4b-binding protein: a forgotten factor in thrombosis and hemostasis.
- Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
- Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis
- Plasma concentrations of Gas6 and sAxl correlate with disease activity in systemic lupus erythematosus.
- Relationship of plasma apolipoprotein M with proprotein convertase subtilisin-kexin type 9 levels in non-diabetic subjects
- Relationship of plasma apolipoprotein M with proprotein convertase subtilisin-kexin type 9 levels: modification by adiposity in nondiabetic subjects
- Structural Changes in Apolipoproteins Bound to Nanoparticles
- 2010
- ACTIVE PHOSPHOLIPID TRANSFER PROTEIN (PLTP) REDUCES PROTHROMBIN ACTIVATION AND ATTENUATES BLOOD COAGULATION
- Activated protein C cofactor function of protein S: a critical role for Asp95 in the EGF1-like domain
- An investigation of serum concentration of apoM as a potential MODY3 marker using a novel ELISA.
- Association of apolipoprotein M with high-density lipoprotein kinetics in overweight-obese men
- Dependence on Vitamin K-dependent Protein S for Eukaryotic Cell Secretion of the beta-Chain of C4b-binding Protein
- Dependence on vitamin K-dependent protein S for eukaryotic cell secretion of the {beta}-chain of C4b-binding protein.
- Gas6 is complexed to soluble tyrosine kinase receptor Axl in human blood.
- Growth arrest specific protein 6 (gas6) and its receptors expression and signalling in beta cells
- HDL Stimulates apoM Secretion.
- Individual domains of Tensin2 exhibit distinct subcellular localisations and migratory effects.
- Inhibition of Thrombin Formation by Active Site Mutated (S360A) Activated Protein C
- Mouse ApoM Displays an Unprecedented Seven-Stranded Lipocalin Fold: Folding Decoy or Alternative Native Fold?
- Novel APC-cleavage sites in FVa providing insights into mechanisms of action of APC and its cofactor protein S.
- Opposing Effects of Apolipoprotein M on Catabolism of Apolipoprotein B-Containing Lipoproteins and Atherosclerosis.
- Plasma apolipoprotein M responses to statin and fibrate administration in type 2 diabetes mellitus
- Plasma concentrations of Gas6 (growth arrest specific protein 6) and its soluble tyrosine kinase receptor sAxl in sepsis and systemic inflammatory response syndromes
- Plasma concentrations of Gas6 and soluble Axl correlate with disease and predict mortality in patients with critical limb ischemia.
- Plasma concentrations of apolipoproteins A-I, B, and M in patients with abdominal aortic aneurysms.
- Plasma concentrations of apolipoproteins A-I, B, and M in patients with critical limb ischemia.
- Plasma concentrations of growth arrest specific protein 6 and the soluble form of its tyrosine kinase receptor Axl as markers of large abdominal aortic aneurysms.
- Plasma levels of apolipoprotein M in normal and complicated pregnancy.
- Reevaluation of the role of HDL in the anticoagulant activated protein C system in humans.
- Tensin2 reduces intracellular phosphatidylinositol 3,4,5-trisphosphate levels at the plasma membrane.
- The D2194G mutation is responsible for increased levels of FV1 in carriers of the factor V R2 haplotype
- The role of phospholipid transfer protein in lipoprotein-mediated neutralization of the procoagulant effect of anionic liposomes.
- Umbilical cord plasma levels of growth-arrest specific protein 6 in intrauterine growth restriction
- 2009
- Anionic Phospholipids Lose their Procoagulant Properties when Incorporated into High-Density Lipoproteins.
- Anticoagulant Properties Of Apolipoprotein A-I And Phospholipid Transfer Protein
- ApoM: gene regulation and effects on HDL metabolism
- Apolipoprotein M affecting lipid metabolism or just catching a ride with lipoproteins in the circulation?
- Apolipoprotein M is decreased in type 2 diabetes and affects pre beta high density lipoprotein formation and cellular cholesterol efflux
- Apolipoprotein M predicts pre-beta-HDL formation: studies in type 2 diabetic and nondiabetic subjects
- Complete high-density lipoproteins in nanoparticle corona.
- Differential expression of Axl and Gas6 in renal cell carcinoma reflecting tumor advancement and survival.
- Expression Of Apolipoprotein M In Fetal Liver: Impact Of Maternal Diabetes
- Gas6 and the receptor tyrosine kinase Axl in clear cell renal cell carcinoma.
- Mouse recombinant protein C variants with enhanced membrane affinity and hyper-anticoagulant activity in mouse plasma.
- Plasma apolipoprotein M is reduced in metabolic syndrome but does not predict intima media thickness
- Platelet Factor 4 Impairs the Anticoagulant Activity of Activated Protein C
- Protein GAS6 and its receptor Axl are expressed and operate in pancreatic beta cells
- Recombinant Apolipoprotein M Secretion Stimulated By HDL
- Recombinant Apolipoprotein M Secretion Stimulated By HDL
- Relationship Between Plasma Apolipoprotein-M And High Density Lipoprotein Apoa Kinetics In Men
- Serendipitous Fatty Acid Binding Reveals the Structural Determinants for Ligand Recognition in Apolipoprotein M
- Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer.
- 2008
- Advances in understanding pathogenic mechanisms of thrombophilic disorders.
- Apolipoprotein M associates to lipoproteins through its retained signal peptide.
- Apolipoprotein M: structure and function
- Carriership of factor v leiden and evolutionary selection advantage.
- Early days of APC resistance and FV Leiden.
- Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice
- Effects of prothrombin on the individual activated protein C-mediated cleavages of coagulation factor Va.
- Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes
- Genetic loss of Gas6 induces plaque stability in expeximental atherosclerosis
- Identification of surface epitopes of human coagulation factor Va that are important for interaction with activated protein C and heparin
- Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies
- Lipid metabolism: why is apoM an apolipoprotein?
- Mapping of the factor Xa-binding site on factor Va by site-directed mutagenesis.
- Re-evaluation of the role of the protein S-C4b binding protein complex in activated protein C-catalyzed factor Va-inactivation
- The Tensin Family Of Putative Metastasis Suppressor Proteins Are Down-Regulated In Human Kidney Cancer
- The signal peptide anchors apolipoprotein m in plasma lipoproteins and prevents rapid clearance of apolipoprotein M from plasma
- The signal peptide anchors apolipoprotein m in plasma lipoproteins and prevents rapid clearance of apolipoprotein m from plasma
- 2007
- An ELISA for apolipoprotein M reveals a strong correlation to total cholesterol in human plasma
- Antithrombotic and anticoagulant effects of wild type and Gla-domain mutated human activated protein C in rats.
- C4b-binding protein and factor h compensate for the loss of membrane-bound complement inhibitors to protect apoptotic cells against excessive complement attack
- C4b-bindingprotein and factor H compensate for the loss of membrane-bound complement inhibitors to protect apoptotic cells against excessive complement attack
- Coagulation factorV and thrombophilia: Background and mechanisms
- Downregulation of C1-TEN expression in human cancer
- Hydrophobic ligand binding properties of the human lipocalin apolipoprotein M
- The role of thrombin exosites I and II in the activation of human coagulation factor V
- The tale of protein S and C4b-binding protein, a story of affection
- 2006
- Activated protein C resistance - in the absence of factor V Leiden - and pregnancy.
- Apolipoprotein M - a novel player in high-density lipoprotein metabolism and atherosclerosis.
- Apolipoprotein M: Progress in understanding its regulation and metabolic functions
- Effects of factor Xa and protein S on the individual activated protein C-mediated cleavages of coagulation factor Va.
- Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily.
- Isolation and characterization of human apolipoprotein M-containing lipoproteins
- Megalin is a receptor for apolipoprotein M and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein M.
- Multifunctional specificity of the protein C/activated protein C Gla domain
- Proposed structural models of the prothrombinase (FXa-FVa) complex
- Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases.
- 2005
- Analysis of Gas6 in Human Platelets and Plasma.
- Blood coagulation and its regulation by anticoagulant pathways: genetic pathogenesis of bleeding and thrombotic diseases.
- C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration
- Large deletions of the PROS1 gene in a large fraction of mutationnegative patients with protein S deficiency
- Molecular coagulation and thrombophilia.
- Regulation of Blood Coagulation by the Protein C Anticoagulant Pathway. Novel Insights Into Structure-Function Relationships and Molecular Recognition.
- Selective modulation of protein C affinity for EPCR and phospholipids by Gla domain mutation
- The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases.
- The anticoagulant protein C pathway.
- The importance of the protein C system in the pathogenesis of venous thrombosis.
- 2004
- Altered inactivation pathway of factor Va by activated protein C in the presence of heparin
- Anticoagulant factor V and thrombosis risk
- Characterization of apoM in normal and genetically modified mice
- Co-segregation of the PROS1 locus and protein S deficiency in families having no detectable mutations in PROS1.
- Complement inhibitor C4b-binding protein-friend or foe in the innate immune system?
- Enhanced rate of cleavage at Arg306 and Arg506 in coagulation factor Va by Gla domain-mutated human activated protein C.
- Functional characterization of Factor V-Ile359Thr, a novel mutation associated with thrombosis.
- Functional properties of recombinant factor V mutated in a potential calcium-binding site.
- Functions of human complement inhibitor C4b-binding protein in relation to its structure.
- Identification of the MMRN1 binding region within the C2 domain of human factor V
- Ligand recognition and homophilic interactions in Tyro3 - Structural insights into the Axl/Tyro3 receptor tyrosine kinase family
- Progress in the understanding of the protein C anticoagulant pathway.
- Structural stability and heat-induced conformational change of two complement inhibitors: C4b-binding protein and factor H.
- The C4b-binding protein-protein S complex inhibits the phagocytosis of apoptotic cells.
- The multiple faces of the partial thromboplastin time APTT.
- Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts.
- 2003
- Activated protein C resistance (FVLeiden) and thrombosis: factor V mutations causing hypercoagulable states
- Anti-factor V auto-antibody in the plasma and platelets of a patient with repeated gastrointestinal bleeding
- C4b-binding protein (C4BP) activates B cells through the CD40 receptor
- CCP1-4 of the C4b-binding protein alpha-chain are required for factor I mediated cleavage of complement factor C3b.
- Congenital and acquired activated protein C resistance.
- Diagnosing protein S deficiency: analytical considerations.
- Factor V Leiden in pregnancies complicated by placental abruption
- Factor V Leiden in pregnancies complicated by placental abruption
- Factor V New Brunswick: Ala221Val associated with FV deficiency reproduced in vitro and functionally characterized.
- Factor VI359T: a novel mutation associated with thrombosis and resistance to activated protein C
- Gla-domain mutated human protein C exhibiting enhanced anticoagulant activity and increased phospholipid binding.
- Importance of protein S and phospholipid for activated protein C-mediated cleavages in factor Va.
- Interactions between surface proteins of Streptococcus pyogenes and coagulation factors modulate clotting of human plasma.
- Low-molecular-weight heparin (dalteparin) effectively prevents thrombosis in a rat model of deep arterial injury.
- Molecular recognition in the protein C anticoagulant pathway.
- Mutations in {alpha}-Chain of C4BP That Selectively Affect Its Factor I Cofactor Function.
- Prevention of thrombosis following deep arterial injury in rats by bovine activated protein C requiring co-administration of bovine protein S.
- Reactions to awareness of activated protein C resistance carriership: a descriptive study of 270 women.
- Role of CCP2 of the C4b-binding protein beta-chain in protein S binding evaluated by mutagenesis and monoclonal antibodies.
- Successful hunt for quantitative trait locus in thrombophilia
- The binding of protein S and the protein S-C4BP complex to neutrophils is apoptosis dependent.
- The discovery of activated protein C resistance.
- 2002
- Defining the factor Xa-binding site on factor Va by site-directed glycosylation.
- Factor V Leiden and the genetics of myocardial infarction: we need to look elsewhere.
- Factor V and thrombotic disease: description of a janus-faced protein.
- Functional characterization of recombinant FV Hong Kong and FV Cambridge.
- Genetic and phenotypic variability between families with hereditary protein S deficiency
- Individual risk assessment of thrombosis in pregnancy.
- Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin.
- Molecular basis of quantitative factor V deficiency associated with factor V R2 haplotype.
- Multicentre evaluation of IL Test (TM) Free PS: A fully automated assay to quantify Free Protein S
- Rapid intracellular degradation of a truncated mutant protein S (Q522X)
- Structural requirements for the intracellular subunit polymerization of the complement inhibitor C4b-binding protein.
- Structural requirements of anticoagulant protein S for its binding to the complement regulator c4b-binding protein
- Thrombin-mediated proteolysis of factor V resulting in gradual B-domain release and exposure of the factor Xa-binding site.
- Vitamin k-dependent protein s localizing complement regulator c4b-binding protein to the surface of apoptotic cells.
- 2001
- A novel interaction between type IV pili of Neisseria gonorrhoeae and the human complement regulator C4B-binding protein
- Analytical considerations for free protein S assays in protein S deficiency
- Binding of C4b-binding protein: A molecular mechanism of serum resistance of Neisseria gonorrhoeae
- Bordetella pertussis binds to human C4b-binding protein (C4BP) at a site similar to that used by the natural ligand C4b
- C4bp binding to porin mediates stable serum resistance of Neisseria gonorrhoeae
- Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis
- Improved hemoglobin status and reduced menstrual blood loss among female carriers of factor V Leiden--an evolutionary advantage?
- Localization of a hydrophobic binding site for anticoagulant protein S on the beta -chain of complement regulator C4b-binding protein
- Proposed lipocalin fold for apolipoprotein M based on bioinformatics and site-directed mutagenesis
- Screening the molecular surface of human anticoagulant protein C: a search for interaction sites
- Structural and energetic characteristics of the heparin-binding site in antithrombotic protein C
- Structural requirements for the complement regulatory activities of C4BP
- Three-dimensional model of the SHBG-like region of anticoagulant protein S: New structure-function insights
- 2000
- 1999
- 1998
- 1995
- 1994
- Differential regulation of alpha and beta chains of C4b-binding protein during acute-phase response resulting in stable plasma levels of free anticoagulant protein S.
- Linkage between inherited resistance to activated protein C and factor V gene mutation in venous thrombosis
- Myocardial infarction associated with homozygous resistance to activated protein C
