Sten Eirik W Jacobsen
Titel
Professor
Organisation
Sten_Eirik_W [dot] Jacobsen [at] med [dot] lu [dot] se
Publikationer (hämtat ur Lunds universitets publikationsdatabas)
författare
- 2012
- Adaptor Protein LNK Is a Negative Regulator of Brain Neural Stem Cell Proliferation after Stroke.
- Emergence of NK cell progenitors and functionally competent NK cell lineage subsets in the early mouse embryo.
- Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model.
- Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow
- The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential.
- 2011
- FLT3 expression initiates in fully multipotent mouse hematopoietic progenitor cells
- Impact of gene dosage, loss of wild type allele and FLT3 ligand on Flt3-ITD induced myeloproliferation.
- Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation
- Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors.
- 2010
- Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development.
- Identification of a NK/T cell restricted progenitor in adult bone marrow contributing to bone marrow and thymic-dependent NK cells.
- Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells
- Maintenance treatment with azacytidine for patients with high-risk myelodysplastic syndromes (MDS) or acute myeloid leukaemia following MDS in complete remission after induction chemotherapy
- Persistent malignant stem cells in del(5q) myelodysplasia in remission.
- 2009
- Characterization of bone marrow-derived mesenchymal stromal cells (MSC) based on gene expression profiling of functionally defined MSC subsets.
- DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction
- Distinct and overlapping patterns of cytokine regulation of thymic and bone marrow-derived NK cell development.
- FLT3 receptor and ligand are dispensable for maintenance and post-transplantation expansion of mouse hematopoietic stem cells.
- FLT3 receptor and ligand are dispensable for maintenance and posttransplantation expansion of mouse hematopoietic stem cells
- Further characterization of committed NK progenitors in adult bone marrow
- Further characterization of committed NK progenitors in adult bone marrow
- Hematopoietic Stem Cell Expansion Precedes the Generation of Committed Myeloid Leukemia-initiating Cells in C/EBP alpha Mutant AML
- High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle
- In Infant ALL with t(4;11)/MLL-AF4 Multiple and Phenotypically Distinct CD19+BM Subsets Initiate Leukemia in NOD/SCID Mice
- In infant all with T(4;11)/MLL-AF4 multiple and phenotypically distinct BM subsets initiate leukemia into NOD/SCID mice
- Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke.
- Polyclonal T-cell reconstitution of X-SCID recipients after in utero transplantation of lymphoid-primed multipotent progenitors
- 2008
- B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells
- Bytte mellom legemidler - nok en gang
- Delineating the cellular pathways of hematopoietic lineage commitment.
- Distinct roles of integrins alpha 6 and alpha 4 in fetal liver hematopoietic stem and progenitor cell homing
- Downregulation of Mpl marks the transition to lymphoid-primed multipotent progenitors with gradual loss of granulocyte-monocyte potential.
- Exit of pediatric pre-B acute lymphoblastic leukaemia cells from the bone marrow to the peripheral blood is not associated with cell maturation or alterations in gene expression.
- FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B Lymphopoiesis.
- Involvement of CCR9 at multiple stages of adult T lymphopoiesis.
- Kit regulates maintenance of quiescent hematopoietic stem cells.
- Modeling of C/EBP alpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells
- Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.
- NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements
- Permissive roles of hematopoietin and cytokine tyrosine kinase receptors in early T cell development
- Polyclonal T cell reconstitution of X-SCID recipients following in utero transplantation of lymphoid-primed multipotent progenitors.
- Protein kinase B (c-akt) regulates hematopoietic lineage choice decisions during myelopoiesis
- 2007
- Biological and molecular evidence for existence of lymphoid-primed multipotent progenitors
- Bytte mellom legemidler - bioekvivalens ikke nodvendig?
- CD133 is not present on neurogenic astrocytes in the adult subventricular zone, but on embryonic neural stem cells, ependymal cells, and glioblastoma cells
- Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBP alpha interaction
- Critical role of FLT3 ligand in IL-7 receptor-independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors
- Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells.
- Crucial role of FLT3 ligand in immune reconstitution following bone marrow transplantation and high dose chemotherapy.
- Delineation of the earliest lineage commitment steps of haematopoietic stem cells: new developments, controversies and major challenges
- Distinct roles of integrins {alpha}6 and {alpha}4 in homing of fetal liver hematopoietic stem and progenitor cells.
- Ectopic expression of PAX5 promotes self renewal of bi-phenotypic myeloid progenitors co-expressing myeloid and B-cell lineage associated genes.
- FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia
- Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors.
- Potential risks of bone marrow cell transplantation into infarcted hearts
- TSLP-mediated fetal B lymphopoiesis?
- The molecular signature of MDS stem cells supports a stem-cell origin of 5q - myelodysplastic syndromes
- 2006
- Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block
- Contribution of {alpha}6-integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with {alpha}4-integrins.
- Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK.
- Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium
- Failure of Transplanted Bone Marrow Cells to Adopt a Pancreatic {beta}-Cell Fate.
- Failure of transdifferentiation of adult hematopoietic stem cells into neurons.
- Prolonged cell cycle transit is a defining and developmentally conserved hemopoietic stem cell property.
- Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis.
- 2005
- Biosynthetic profiles of neutrophil serine proteases in a human bone marrow-derived cellular myeloid differentiation model
- Biosynthetic profiles of neutrophil serine proteases in a human bone marrow-derived cellular myeloid differentiation model.
- Deficiency of oncoretrovirally transduced hematopoietic stem cells and correction through ex vivo expansion.
- Defining 'stemness': Notch and Wnt join forces?
- Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2
- Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia.
- IFN-{gamma} Negatively Modulates Self-Renewal of Repopulating Human Hemopoietic Stem Cells.
- Identification of Flt3(+) lympho-myeloid stem cells lacking erythro-megakaryocytic potential: A revised road map for adult blood lineage commitment
- Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment
- Identification of Lin-Sca1+kit+CD34+Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated recipients.
- Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage
- 2004
- Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation.
- Deceptive multilineage reconstitution analysis of mice transplanted with hemopoietic stem cells, and implications for assessment of stem cell numbers and lineage potentials.
- Enforced expression of cyclin D2 enhances the proliferative potential of myeloid progenitors, accelerates in vivo myeloid reconstitution, and promotes rescue of mice from lethal myeloablation.
- MDS/AML-associated cytogenetic abnormalities in multiple myeloma and monoclonal gammopathy of undetermined significance: Evidence for frequent de novo occurrence and multipotent stem cell involvement of del(20q).
- P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells.
- 2003
- Human CD34+ hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express flt3: distinct flt3 and c-kit expression and response patterns on mouse and candidate human hematopoietic stem cells.
- Human reconstituting hematopoietic stem cells up-regulate Fas expression upon active cell cycling but remain resistant to Fas-induced suppression.
- Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells
- 2002
- Efficient Oncoretroviral Transduction of Extended Long-Term Culture-Initiating Cells and NOD/SCID Repopulating Cells: Enhanced Reconstitution with Gene-Marked Cells Through an Ex Vivo Expansion Approach.
- Involvement and functional impairment of the CD34(+)CD38(-)Thy-1(+) hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8.
- Key Role of flt3 Ligand in Regulation of the Common Lymphoid Progenitor but Not in Maintenance of the Hematopoietic Stem Cell Pool.
- Transient disruption of autocrine TGF-beta signaling leads to enhanced survival and proliferation potential in single primitive human hemopoietic progenitor cells.
- 2001
- Self-renewal of multipotent long-term repopulating hematopoietic stem cells is negatively regulated by Fas and tumor necrosis factor receptor activation
- Tumor necrosis factor (TNF)-mediated activation of the p55 TNF receptor negatively regulates maintenance of cycling reconstituting human hematopoietic stem cells
- Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity
- 2000
- 1999
