Cecilia Holm

författare

• 2013
  • Partial Inhibition of Adipose Tissue Lipolysis Improves Glucose Metabolism and Insulin Sensitivity Without Alteration of Fat Mass
• 2012
  • Characterization of the Lipid Droplet Proteome of a Clonal Insulin-producing β-Cell Line (INS-1 832/13).
  • Diverse effects of oats on cholesterol metabolism in C57BL/6 mice correlate with expression of hepatic bile acid-producing enzymes.
  • Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese persons.
  • Green tea powder and Lactobacillus plantarum affect gut microbiota, lipid metabolism and inflammation in high-fat fed C57BL/6J mice
• 2011
  • Altered Desaturation and Elongation of Fatty Acids in Hormone-Sensitive Lipase Null Mice
  • Altered desaturation and elongation of Fatty acids in hormone-sensitive lipase null mice.
  • Rose hip exerts antidiabetic effects via a mechanism involving downregulation of the hepatic lipogenic program
  • Rye bran alkylresorcinols suppress adipocyte lipolysis and hormone-sensitive lipase activity
• 2010
  • A low glycaemic diet improves oral glucose tolerance but has no effect on β-cell function in C57BL/6J mice.
  • Dose-dependent anti-obesity and anti-diabetic effects of synbiotics in high-fat fed C57BL/6J mice
  • Expression of nonalcoholic fatty liver disease associated adiponutrin variant I148M causes triglyceride accumulation
  • Metabolic effects of whole grain wheat and whole grain rye in the C57BL/6J mouse.
  • Quarternary structure and enzymological properties of the different hormone-sensitive lipase (HSL) isoforms.
  • Rose hip exerts anti diabetic effects via a mechanism involving downregulation of the hepatic lipogenic program
• 2009
  • A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis.
  • Activation of Hormone-sensitive Lipase Requires Two Steps, Protein Phosphorylation and Binding to the PAT-1 Domain of Lipid Droplet Coat Proteins
  • Endosperm and whole grain rye breads are characterized by low post-prandial insulin response and a beneficial blood glucose profile
  • Hormone-sensitive lipase (HSL) is also a retinyl ester hydrolase: evidence from mice lacking HSL.
  • Omics Analyses Reveal a Potential Link between Hormone-Sensitive Lipase and Polyamine Metabolism.
  • Perilipin is present in islets of Langerhans and protects against lipotoxicity when overexpressed in the beta-cell line INS-1.
  • Phosphorylation of hormone-sensitive lipase by protein kinase A in vitro promotes an increase in its hydrophobic surface area.
• 2008
  • Attainment of brown adipocyte features in white adipocytes of hormone-sensitive lipase null mice.
  • Disturbed cholesterol homeostasis in hormone-sensitive lipase null mice.
  • Hormone-sensitive lipase is necessary for normal mobilization of lipids during sub-maximal exercise.
  • Lack of cholesterol mobilization in islets of hormone-sensitive lipase deficient mice impairs insulin secretion.
  • Metabolomic and proteomic analysis of a clonal insulin-producing beta-cell line (INS-1 832/13).
  • Ser649 and Ser650 are the major determinants of protein kinase A-mediated activation of human hormone-sensitive lipase against lipid substrates.
• 2007
  • Adipose TriGlyceride Lipase (ATGL) and Hormone-Sensitive Lipase (HSL) protein expression is decreased in the obese insulin resistant state.
  • Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane.
  • Metabolic Effects of Dietary Glycaemic Index in the C57BL/6J Mouse
  • Metabolic properties of rye
• 2006
  • Comparison of MS/MS methods for protein identification from 2D-PAGE
  • Decrease in intramuscular lipid droplets and translocation of HSL in response to muscle contraction and epinephrine
  • Glucose-stimulated insulin secretion correlates with beta-cell lipolysis.
  • Inflammatory response in white adipose tissue in the non-obese hormone-sensitive lipase null mouse model.
  • The hormone-sensitive lipase C-60G promoter polymorphism is associated with increased waist circumference in normal-weight subjects.
  • The metabolic effects of whole grain wheat and rye in C57BL/6J mice
  • {beta}-Cell Lipases and Insulin Secretion.
• 2005
  • Adipocyte lipases and defect of lipolysis in human obesity
  • Continuous separation of lipid particles from erythrocytes by means of laminar flow and acoustic standing wave forces
  • Design of cereal foods with advantageous effects in relation to IRS; Exploiting a combination of functional food concepts
  • Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting
  • Hormone-Sensitive Lipase as Mediator of Lipolysis in Contracting Skeletal Muscle.
  • Marked Re-Utilization of Free Fatty Acids During Activated Lipolysis in Human Skeletal Muscle.
  • Transcriptome and proteome analysis of soleus muscle of hormone-sensitive lipase-null mice
• 2004
  • A novel hormone-sensitive lipase isoform expressed in pancreatic beta -cells.
  • Amino-terminal anchored surface display in insect cells and budded baculovirus using the amino-terminal end of neuraminidase.
  • Contractions induce phosphorylation of the AMPK site Ser(565) in hormone-sensitive lipase in muscle
  • Effects of Growth Hormone on the Function of beta-Adrenoceptor Subtypes in Rat Adipocytes.
  • Hormone-sensitive Lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact.
  • Inhibition of lipase activity and lipolysis in rat islets reduces insulin secretion.
  • Palmitate Stimulation of Glucagon Secretion in Mouse Pancreatic {alpha}-Cells Results From Activation of L-Type Calcium Channels and Elevation of Cytoplasmic Calcium.
  • Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells.
  • Particle separation using ultrasound can radically reduce embolic load to brain after cardiac surgery.
  • Regulation and role of hormone-sensitive lipase in rat skeletal muscle
  • Separation of lipids from blood utilizing ultrasonic standing waves in microfluidic channels.
  • The testicular form of hormone-sensitive lipase HSLtes confers rescue of male infertility in HSL-deficient mice
• 2003
  • Contractions activate hormone-sensitive lipase in rat muscle by protein kinase C and mitogen-activated protein kinase
  • Downregulation of islet hormone-sensitive lipase during long-term high-fat feeding.
  • Hormone-sensitive lipase in skeletal muscle: regulatory mechanisms.
  • Hormone-sensitive lipase is a cholesterol esterase of the intestinal mucosa
  • Hormone-sensitive lipase null mice exhibit signs of impaired insulin sensitivity whereas insulin secretion is intact.
  • Molecular mechanisms regulating hormone-sensitive lipase and lipolysis.
  • Mutational analysis of the hormone-sensitive lipase translocation reaction in adipocytes
  • Pancreatic beta-Cell Lipotoxicity Induced by Overexpression of Hormone-Sensitive Lipase.
  • Relationship of the Hormone-Sensitive Lipase-Mediated Modulation of Cholesterol Metabolism in Individual Compartments of the Testis to Serum Pituitary Hormone and Testosterone Concentrations in a Seasonal Breeder, the Mink (Mustela vison).
  • The Presence of a Catalytically Inactive Form of Hormone-Sensitive Lipase Is Associated With Decreased Lipolysis in Abdominal Subcutaneous Adipose Tissue of Obese Subjects.
• 2002
  • A unique defect in the regulation of visceral fat cell lipolysis in the polycystic ovary syndrome as an early link to insulin resistance
  • C(2)-ceramide influences the expression and insulin-mediated regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 adipocytes.
  • Characterization of a novel testicular form of human hormone-sensitive lipase
  • Major gentler differences in the lipolytic capacity of abdominal subcutaneous fat cells in obesity observed before and after long-term weight reduction
• 2001
  • A role for hormone-sensitive lipase in the selective mobilization of adipose tissue fatty acids
  • Expression, activity, and subcellular localization of testicular hormone-sensitive lipase during postnatal development in the guinea pig
  • Fatty acid specificity of hormone-sensitive lipase: implication in the selective hydrolysis of triacylglycerols
  • Long-term leptin treatment of ob/ob mice improves glucose-induced insulin secretion
  • Overexpression of hormone-sensitive lipase in beta-cells results in blunted glucose stimulated insulin secretion after feeding mice a high-fat diet
  • Testis hormone-sensitive lipase expression in spermatids is governed by a short promoter in transgenic mice
  • The effect of exercise training on hormone-sensitive lipase in rat intra-abdominal adipose tissue and muscle
  • The expression of hormone-sensitive lipase in clonal beta-cells and rat islets is induced by long-term exposure to high glucose
• 1999
  • Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells
• 1998
  • Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro
  • Protein kinase B is expressed in pancreatic beta cells and activated upon stimulation with insulin-like growth factor I
• 1997
  • 2 Regulation of hormone-sensitive lipase activity in adipose tissue
  • Partial purification and identification of hormone-sensitive lipase from chicken adipose tissue
• 1996
  • Domain-structure analysis of recombinant rat hormone-sensitive lipase
• 1994
  • Localization of hormone-sensitive lipase to rat Sertoli cells and its expression in developing and degenerating testes
• 1993
  • Gene organization and primary structure of human hormone-sensitive lipase: possible significance of a sequence homology with a lipase of Moraxella TA144, an antarctic bacterium