Magnus Abrahamson

författare

• 2013
  • Cystatin C properties crucial for uptake and inhibition of intracellular target enzymes.
  • Stabilization, Characterization and Selective Removal of Cystatin C Amyloid Oligomers.
• 2012
  • Intra- and extracellular regulation of activity and processing of legumain by cystatin E/M
  • Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment
• 2011
  • Cleavage of IgG1 and IgG3 by gingipain K from Porphyromonas gingivalis may compromise host defense in progressive periodontitis.
• 2010
  • Cystatin E/M suppresses legumain activity and invasion of human melanoma
  • Cystatins - Extra- and Intracellular Cysteine Protease Inhibitors: High-level Secretion and Uptake of Cystatin C in Human Neuroblastoma Cells.
  • Phenotype associated with mutation in the recently identified autosomal dominant retinitis pigmentosa KLHL7 gene.
  • Streptococcal inhibitor of complement-mediated lysis (SIC): an anti-inflammatory virulence determinant
  • Streptococcal protein SIC: An anti-inflammatory virulence determinant.
• 2009
  • Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases
  • Cystatin C is downregulated in prostate cancer and modulates invasion of prostate cancer cells via MAPK/Erk and androgen receptor pathways.
  • Macrophage Responses to Interferon-gamma are Dependent on Cystatin C Levels.
  • Mutations in a BTB-Kelch Protein, KLHL7, Cause Autosomal-Dominant Retinitis Pigmentosa
• 2008
  • Displacement of the occluding loop by the parasite protein, chagasin, results in efficient inhibition of human cathepsin
  • Internalization of cystatin C in human cell lines.
  • The Human Protease Inhibitor Cystatin C Is an Activating Cofactor for the Streptococcal Cysteine Protease IdeS.
  • rd1 Mouse retina shows an imbalance in the activity of cysteine protease cathepsins and their endogenous inhibitor cystatin C.
• 2007
  • Crystal Structure of the Parasite Protease Inhibitor Chagasin in Complex with a Host Target Cysteine Protease.
  • Cystatin C binds serum amyloid A, downregulating its cytokine-generating properties
  • Down-regulation of human extracellular cysteine protease inhibitors by the secreted staphylococcal cysteine proteases, staphopain A and B.
  • Low glutathione peroxidase in rd1 mouse retina increases oxidative stress and proteases.
  • Low glutathione peroxidase in rdl mouse retina increases oxidative stress and proteases
  • The cysteine protease inhibitors cystatins inhibit herpes simplex virus type 1-induced apoptosis and virus yield in HEp-2 cells
  • The cysteine proteinase inhibitors cystatins inhibit herpex simplex virus type 1-induced apoptosis and virus yield in HEp-2 cells
  • The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family
• 2006
  • Aberrant expression of cystatin C in prostate cancer is associated with neuroendocrine differentiation.
  • Cystatins in non-small cell lung cancer: Tissue levels, localization and relation to prognosis
  • Human cystatins - similarities, diversity and classification
  • Structural and protease inhibitory features of cystatins
  • rd1 Mouse Retina Shows Imbalance in Cellular Distribution and Levels of TIMP-1/MMP-9, TIMP-2/MMP-2 and Sulfated Glycosaminoglycans.
• 2005
  • 3D domain-swapped human cystatin c with amyloidlike intermolecular beta-sheets
  • Clinical phenotype in a Swedish family with a mutation in the IMPDH1 gene.
  • Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile.
  • Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus in mouse
  • Cystatin C uptake in the eye.
  • Different cysteine proteinases involved in bone resorption and osteoclast formation
  • In search of selective inhibitors of cysteine protease, cathepsin K
  • Inhibitory properties of cystatin F and its localization in U937 promonocyte cells
  • Juvenile X-linked retinoschisis with normal scotopic b-wave in the electroretinogram at an early stage of the disease.
  • Novel azapeptide inhibitors of cathepsins B and K. Structural background to increased specificity for cathepsin B
• 2004
  • Cystatin C in the anterior segment of rat and mouse eyes.
  • Cystatin C is highly expressed in the human male reproductive system.
  • Cysteine proteinases in osteoclast function and recruitment
  • Domain swapping in N-truncated human cystatin C
  • Engineered multidomain cysteine protease inhibitors yield resistance against western flower thrips (Franklinielia occidentalis) in greenhouse trials
  • Enzymatic characterization of the streptococcal endopeptidase, IdeS, reveals that it is a cysteine protease with strict specificity for igg cleavage due to exosite binding.
  • Glutathione S-transferase µ(GST) modifies activities of proteases and levels of cystatin C secreted by mouse retinal explants
  • Osteoclastogenesis is decreased by cysteine proteinase inhibitors
  • Specific cysteine protease inhibitors act as deterrents of western flower thrips, Frankliniella occidentalis (Pergande), in transgenic potato
• 2003
  • Cathepsin B in the rat eye.
  • Cystatins.
  • Growth of the postnatal rat retina in vitro: Quantitative RT-PCR analyses of mRNA expression for photoreceptor proteins
  • Growth of the postnatal rat retina in vitro: quantitative RT-PCR analyses of mRNA expression for photoreceptor proteins.
  • Macular appearance by means of OCT and electrophysiology in members of two families with different mutations in RDS (the peripherin/RDS gene).
• 2002
  • Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases
  • Physico-chemical properties of the N-terminally truncated L68Q cystatin C found in amyloid deposits of brain haemorrhage patients.
  • Regulated expression and intracellular localization of cystatin F in human U937 cells.
  • Structure-based design and synthesis of cathepsin K inhibitors
• 2001
  • Different clinical expressions in two families with Stargardt's macular dystrophy (STGD1)
  • Electrophysiologic findings in two young patients with Bothnia dystrophy and a mutation in the RLBP1 gene
  • Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping
  • Identification and localization of retinal cystatin C
  • Identification, characterization and localization of chagasin, a tight-binding cysteine protease inhibitor in Trypanosoma cruzi
  • Lysosomal protease pathways to apoptosis - Cleavage of Bid, not pro-caspases, is the most likely route
  • Peptidyl aldehydes based on N-terminal binding fragments of cystatins as thioprotease inhibitors
  • Peptidyl diazomethylketones as cysteine protease inhibitors structurally based upon the inhibitory centers of cystatins
• 2000
  • A peptidyl derivative structurally based on the inhibitory center of cystatin C inhibits bone resorption in vitro
  • Cystatin inhibition of cathepsin B requires dislocation of the proteinase occluding loop. Demonstration by release of loop anchoring through mutation of His110
  • Expression of an LDL receptor allele with two different mutations (E256K and I402T)
  • Functional effects of the inhibition of the cysteine protease activity of the major house dust mite allergen Der p 1 by a novel peptide-based inhibitor
• 1999
  • An individual with a healthy phenotype in spite of a pathogenic LDL receptor mutation (C240F)
  • An individual with healthy phenotype in spite of a pathogenic LDL receptor mutation (C240F)
  • Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor gene
  • Digenic inheritance of a ROM1 gene mutation with a peripherin/RDS or rhodopsin mutation in families with retinitis pigmentosa
  • Expression of a selenomethionine derivative and preliminary crystallographic studies of human cystatin C
  • Inhibition of mammalian legumain by some cystatins is due to a novel second reactive site
  • Modulation of invasive properties of murine squamous carcinoma cells by heterologous expression of cathepsin B and cystatin C
• 1998
  • A 50-year perspective of a family with chromosome 14-linked Alzheimer’s disease
  • A Swedish family with a mutation in the peripherin/RDS gene (Arg-172-Trp) associated with a progressive retinal degeneration
  • Amino acid substitutions in the N-terminal segment of cystatin C create selective inhibitors of lysosomal cysteine proteinases
  • Clinical expression of X-linked retinitis pigmentosa in a Swedish family with the RP2 genotype
  • Cystatin F is a glycosylated human low molecular weight cysteine proteinase inhibitor
  • Detection of alterations in all three exons of the peripherin/RDS gene in Swedish patients with retinitis pigmentosa using an efficient DGGE system
  • Intracellular accumulation of the amyloidogenic L68Q variant of cystatin C in NIH/3T3 cells
  • Mutations in the low-density lipoprotein receptor gene in Swedish familial hypercholesterolaemia patients: clinical expression and treatment response
  • Phenotype in a Swedish family with X-linked retinitis pigmentosa caused by a novel splice defect in the RPGR gene
  • Phenotypic expression of autosomal dominant retinitis pigmentosa in a Swedish family expressing a Phe-211-Leu variant of peripherin/RDS
  • Structural basis for different inhibitory specificities of human cystatins C and D
  • Two stable unfolding intermediates of the disease-causing L68Q variant of human cystatin C
  • Two-step mechanism of inhibition of cathepsin B by cystatin C, due to the inhibitor displacing the occluding loop of the enzyme
• 1997
  • A mild phenotype of autosomal dominant retinitis pigmentosa is associated with the rhodopsin mutation Pro-267–Leu
  • Affinity purification and elimination of methionine oxidation in recombinant human cystatin C
  • Analysis of the RPGR gene in 11 pedigrees with the retinitis pigmentosa type 3 genotype: Paucity of mutations in the coding region, but splice defects in two families
  • Apolipoprotein E genotyping in Alzheimer’s disease and frontotemporal dementia
  • Autosomal dominant retinitis pigmentosa with a rhodopsin mutation (Arg-135–Trp): Disease phenotype in a Swedish family
  • Cathepsin B and cysteine proteinase inhibitors in human lung cancer cell lines
  • Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins
  • Modification of cystatin C activity by bacterial proteinases and neutrophil elastase in periodontitis
  • NMR structural studies of human cystatin C dimers and monomers
  • Phenotypes in three Swedish families with X-linked retinitis pigmentosa caused by different mutations in the RPGR gene
• 1996
  • Folding related dimerization of human cystatin C
  • Lack of relationship between insertion/deletion polymorphism in the angiotensin converting enzyme gene and severe retinopathy in insulin-dependent diabetes mellitus
  • Molecular basis for amyloidosis related to hereditary brain hemorrhage
  • Mouse and rat cystatin C: Escherichia coli production, characterization and tissue distribution
  • The importance of the second hairpin loop of cystatin C for proteinase binding. Characterization of the interaction of Trp-106 variants of the inhibitor with cysteine proteinases
• 1995
  • An efficient screening procedure detecting six novel mutations in the LDL receptor gene in Swedish children with hypercholesterolemia
  • Antigenicity of cystatin-binding proteins from parasitic protozoan. Detection by a proteinase inhibitor based capture immunoassay (PINC-ELISA)
  • Phenotype variation within a choroideremia family lacking the entire CHM gene
  • Probing the functional role of the N-terminal region of cystatins by equilibrium and kinetic studies of the binding of Gly-11 variants of recombinant human cystatin C to target proteinases
  • Structural basis for the biological specificity of cystatin C. Identification of leucine 9 in the N-terminal binding region as a selectivity-conferring residue in the inhibition of mammalian cysteine peptidases
  • Structural organization, expression and chromosomal mapping of the mouse cystatin C gene (Cst3)
  • Synthesis and secretion of procathepsin B and cystatin C by human bronchial epithelial cells in vitro: modulation of cathepsin B activity by neutrophil elastase
• 1994
  • Cystatins
  • Differential changes in the association and dissociation rate constants for binding of cystatins to target proteinases occurring on N-terminal truncation of the inhibitors indicate that the interaction mechanism varies with different enzymes
  • Evidence for the interaction of valine-10 in cystatin C with the S2 subsite of cathepsin B
  • Increased body temperature accelerates aggregation of the (Leu-68–>Gln) mutant cystatin C, the amyloid-forming protein in hereditary cystatin C amyloid angiopathy
  • Latency of cathepsin B secreted by human colon carcinoma cells is not linked to secretion of cystatin C and is relieved by neutrophil elastase
  • Structural and functional characterization of two allelic variants of human cystatin D sharing a characteristic inhibition spectrum against mammalian cysteine proteinases
• 1993
  • A sequence variation in the human cystatin D gene resulting in an amino acid (Cys/Arg) polymorphism at the protein level
  • An Ala/Thr variation in the coding region of the human cystatin C gene (CST3) detected as a Sst II polymorphism
  • Cystatin C (CST3), the candidate gene for hereditary cystatin C amyloid angiopathy (HCCAA), and other members of the cystatin gene family are clustered on chromosome 20p11.2
  • Cystatins - Protein inhibitors of papain-like cysteine proteinases
  • Human cystatin D: cDNA cloning, characterization of the E. coli expressed inhibitor, and identification of the native protein in saliva
  • Importance of the evolutionarily conserved glycine residue in the N-terminal region of cystatin C (Gly-11) for cysteine endopeptidase inhibition
  • Localization of the human cystatin D gene (CST5) to chromosome 20p11.21 by in situ hybridization
• 1992
  • A novel mutation in the β-protein coding region of the amyloid β-protein precursor (APP) gene
  • A six generation family with autosomal dominant retinitis pigmentosa and a rhodopsin gene mutation (arginine-135–leucine)
  • Cystatin C and cathepsin B in human colon carcinoma: Expression in cell lines and matrix degradation
  • Cystatin C based peptidyl diazomethanes as cysteine proteinase inhibitors: Influence of the peptidyl chain length
  • Demonstration of sequence variations in the promoter region of the human cystatin C gene
  • Hereditary cystatin C amyloid angiopathy: Identification of the disease causing mutation and specific diagnosis by polymerase chain reaction based analysis
  • Interaction of recombinant human cystatin C with the cysteine proteinases papain and actinidin
  • PCR assay for a polymorphic Dde I site in the promoter region of the human cystatin C gene (CST3)
• 1991
  • Determination of allotypes G1m(f) and G1m(z) at the genomic level by subclass specific amplification of DNA and use of allele specific probes
  • Human cystatin C: Role of the N-terminal segment in the inhibition of human cysteine proteinases and in its inactivation by leucocyte elastase
  • Human monoclonal antibodies with different fine-specificity for digoxin derivatives: Cloning of heavy and light chain variable region sequences
  • Human sputum cathepsin B degrades proteoglycan, is inhibited by a2-macroglobulin and modulated by neutrophil elastase cleavage of cathepsin B precursor and cystatin C
  • Regulation of cystatin C activity by serine proteinases
  • Sst II polymorphic sites in the promoter region of the human cystatin C gene
  • Structure and expression of the gene encoding cystatin D, a novel human cysteine proteinase inhibitor
• 1990
  • Assignment of allotypes G1m(a+) and G1m(a-) at the genomic level by polymerase chain reaction analysis
  • Cystatin C mutation causing amyloid angiopathy and brain hemorrhage
  • Interactions of papaya proteinase IV with inhibitors
  • Levels of neutrophil elastase and cathepsin B activities, and cystatins in human sputum: relationship to inflammation
  • Structure and expression of the human cystatin C gene
  • Synthesis of cysteine proteinase inhibitors structurally based on the proteinase interacting N-terminal region of human cystatin C
  • The aminoterminal portion of cerebrospinal fluid cystatin C in hereditary cystatin C amyloid angiopathy is not truncated. Direct sequence analysis from agarose gel electropherograms
  • Three RFLP's at the 3' end of the cystatin C gene, the disease gene in hereditary cystatin C amyloid angiopathy (HCCAA) in Iceland
• 1989
  • An efficient E. coli expression system for human cystatin C: Production and characterization of the native and N-terminally Ala-Met-Glu-Ala-Glu-extended inhibitor
  • Bacterial growth inhibited by a synthetic inhibitor based upon the structure of a human proteinase inhibitor
  • High-level expression of active human cystatin C in Escherichia coli
  • Mutation in the cystatin C gene causes hereditary brain hemorrhage
  • Polymemse chain reaction using mixed primers. Cloning of human monoclonal antibody variable region genes from single hybridoma cells
  • Rapid cloning of rearranged immunoglobulin genes from human hybridoma cells using mixed primers and the polymerase chain reaction
  • Study of restriction fragment length polymorphism in the cystatin C gene of elderly patients with dementia and aged Down's syndrome patients
  • The human cystatin C gene (CST3), mutated in hereditary cystatin C amyloid angiopathy, is located on chromosome 20
• 1988
  • An isolate of families with hereditary cystatin C amyloid angiopathy and cerebral haemorrhage in the south of Iceland
  • Efficient production of native, biologically active human cystatin C by Escherichia coli
  • Human cysteine proteinase inhibitors. Isolation, physiological importance, inhibitory mechanism, gene structure and relation to hereditary cerebral hemorrhage
  • Mutation in cystatin C gene causes hereditary brain haemorrhage
  • Production, characterization and use of monoclonal antibodies against the major extracellular human cysteine proteinase inhibitors cystatin C and kininogen
  • Studies on the cystatin C gene in patients with hereditary cystatin C amyloid angiopathy (HCCAA) with cerebral haemorrhage
• 1987
  • Identification of the probable inhibitory reactive sites of the cysteine proteinase inhibitors human cystatin C and chicken cystatin
  • Molecular cloning and sequence analysis of cDNA coding for the precursor of the human cysteine proteinase inhibitor cystatin C
• 1986
  • Cystatin-like domains of LMW-kininogen, and speculations on the evolution of cystatins
  • Human low-Mr kininogen contains three copies of a cystatin sequence that are divergent in structure and in inhibitory activity for cysteine proteinases.
  • Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids
  • The biochemistry of the action of chymopapain in relief of sciatica