Nils Mandahl
Titel
professor, chefsgenetiker
Organisation
046-173364
Nils [dot] Mandahl [at] med [dot] lu [dot] se
Publikationer (hämtat ur Lunds universitets publikationsdatabas)
författare
- 2012
- Disease-associated patterns of disomic chromosomes in hyperhaploid neoplasms.
- Fusion of the AHRR and NCOA2 genes through a recurrent translocation t(5;8)(p15;q13) in soft tissue angiofibroma results in upregulation of aryl hydrocarbon receptor target genes.
- Molecular genetic characterization of the 11q13 breakpoint in a desmoplastic fibroma of bone
- Recurrent Rearrangement of the PHF1 Gene in Ossifying Fibromyxoid Tumors.
- Retained heterodisomy is associated with high gene expression in hyperhaploid inflammatory leiomyosarcoma.
- The MDM2 SNP309 G allele is not preferentially amplified in bone and soft tissue tumors.
- 2011
- Chromosome banding analysis of cells from fine-needle aspiration biopsy samples from soft tissue and bone tumors: is it clinically meaningful?
- Gene expression and single nucleotide polymorphism array analyses of spindle cell lipomas and conventional lipomas with 13q14 deletion.
- HMGA2 and MDM2 expression in lipomatous tumors with partial, low-level amplification of sequences from the long arm of chromosome 12.
- The t(X;6) in subungual exostosis results in transcriptional deregulation of the gene for insulin receptor substrate 4.
- 2010
- Concomitant deletions of tumor suppressor genes MEN1 and AIP are essential for the pathogenesis of the brown fat tumor hibernoma.
- Fusion of the FUS and CREB3L2 genes in a supernumerary ring chromosome in low-grade fibromyxoid sarcoma.
- Generation of trisomies in cancer cells by multipolar mitosis and incomplete cytokinesis.
- Genomic Changes in Chromosomes 10, 16, and X in Malignant Peripheral Nerve Sheath Tumors Identify a High-Risk Patient Group.
- Genomic characteristics of soft tissue sarcomas.
- 2009
- Bidirectionality and transcriptional activity of the EWSR1 promoter region.
- Characterization of a Hotspot Region on Chromosome 12 for Amplification in Ring Chromosomes in Atypical Lipomatous Tumors
- Cytogenetic Analysis of 101 Giant Cell Tumors of Bone: Nonrandom Patterns of Telomeric Associations and Other Structural Aberrations
- Expression levels of HMGA2 in adipocytic tumors correlate with morphologic and cytogenetic subgroups.
- Genomic profiling of chondrosarcoma: chromosomal patterns in central and peripheral tumors.
- ISCN (2009): Important revisions and new additions to molecular methods for copy number detection for cytogenetic analysis
- Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors
- Telomeric associations correlate with telomere length reduction and clonal chromosome aberrations in giant cell tumor of bone.
- Two genetic pathways, t(1;10) and amplification of 3p11-12, in myxoinflammatory fibroblastic sarcoma, haemosiderotic fibrolipomatous tumour, and morphologically similar lesions.
- 2008
- Cytogenetic and molecular cytogenetic findings in lipoblastoma.
- Frequent deletion of the CDKN2A locus in chordoma: analysis of chromosomal imbalances using array comparative genomic hybridisation.
- Fusion of the COL1A1 and USP6 genes in a benign bone tumor.
- Heterogeneous genetic profiles in soft tissue myoepitheliomas
- Heterogeneous genetic profiles in soft tissue myoepitheliomas.
- Molecular identification of COL6A3-CSF1 fusion transcripts in tenosynovial giant cell tumors
- POU5F1, encoding a key regulator of stem cell pluripotency, is fused to EWSR1 in hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands.
- 2007
- Assessment of the clinical and molecular impact of different cytogenetic subgroups in a series of 272 lipomas with abnormal karyotype.
- Assessment of the clinical and molecular impact of different cytogenetic subgroups in a series of 272 lipomas with abnormal karyotype.
- Characterization of the native CREB3L2 transcription factor and the FUS/CREB3L2 chimera.
- Comparison of the proximal promoter regions of the PAX3 and PAX7 genes
- Fusion genes in angiomatoid fibrous histiocytoma
- Generation of human cortical neurons from a new immortal fetal neural stem cell line.
- Genetic intratumour heterogeneity in high-grade brain tumours is associated with telomere-dependent mitotic instability.
- Microarray analysis of gliomas reveals chromosomal position-associated gene expression patterns and identifies potential immunotherapy targets.
- Successful treatment of a child with t(15;19)-positive tumor.
- Tiling resolution array comparative genomic hybridization analysis of a fibrosarcoma of bone.
- Unstable translocation (8;22) in a case of giant cell reparative granuloma
- Unstable translocation (8;22) in a case of giant cell reparative granuloma.
- 2006
- FISH mapping of i(7q) in acute leukemias and myxoid liposarcoma reveals clustered breakpoints in 7p11.2: implications for formation and pathogenetic outcome of the idic(7)(p11.2).
- Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor.
- Gene copy number changes in dermatofibrosarcoma protuberans - a fine-resolution study using array comparative genomic hybridization
- Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma
- Genomic profiling of bone and soft tissue tumors with supernumerary ring chromosomes using tiling resolution bacterial artificial chromosome microarrays.
- Identification of a novel amplicon at distal 17q containing the BIRC5/SURVIVIN gene in malignant peripheral nerve sheath tumours
- Prognostic Significance of Chromosome Aberrations in High-Grade Soft Tissue Sarcomas.
- Rearrangement of the COL12A1 and COL4A5 genes in subungual exostosis: molecular cytogenetic delineation of the tumor-specific translocation t(X;6)(q13-14;q22)
- Truncation and fusion of HMGA2 in lipomas with rearrangements of 5q32-->q33 and 12q14-->q15.
- 2005
- Absence of mutations of the BRAF gene in malignant melanoma of soft parts (clear cell sarcoma of tendons and aponeuroses).
- Atypical lipomatous tumor with rare structural rearrangements involving chromosomes 8 and 12.
- Biallelic somatic inactivation of the NF1 gene through chromosomal translocations in a sporadic neurofibroma
- Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene.
- Culturing of human tumor cells for use in immune gene tumor therapy
- Ewing tumours and synovial sarcomas have critical features of karyotype evolution in common with epithelial tumours.
- Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma.
- Fusion of the HMGA2 and NFIB genes in lipoma.
- Molecular cytogenetic characterization of an ins(4;X) occurring as the sole abnormality in an aggressive, poorly differentiated soft tissue sarcoma.
- Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity.
- 2004
- A novel FISH assay for SS18-SSX fusion type in synovial sarcoma.
- Abstracts from the Ninth Annual Meeting of the Society for Neuro-Oncology
- Activation of the GLI Oncogene through Fusion with the beta-Actin Gene (ACTB) in a Group of Distinctive Pericytic Neoplasms: Pericytoma with t(7;12).
- Amplification of chromosome 1 sequences in lipomatous tumors and other sarcomas.
- Combined binary ratio labeling fluorescence in situ hybridization analysis of chordoma.
- Expression of DOL54 is not restricted to myxoid liposarcomas with the FUS-DDIT3 chimera but is found in various sarcomas.1
- Genetic characterization of bone and soft tissue tumors
- Mitotic instability associated with late genomic changes in bone and soft tissue tumours.
- Molecular cytogenetic characterization of recurrent translocation breakpoints in bizarre parosteal osteochondromatous proliferation (Nora's lesion).
- Molecular genetic characterization of the genomic ACTB-GLI fusion in pericytoma with t(7;12).
- Retained heterodisomy for chromosome 12 in atypical lipomatous tumors: implications for ring chromosome formation.
- Telomere shortening and mitotic dysfunction generate cytogenetic heterogeneity in a subgroup of renal cell carcinomas.
- 2003
- A novel fusion gene, SS18L1/SSX1, in synovial sarcoma.
- Chromosomal abnormalities in inflammatory pseudotumor of the urinary bladder
- Clustering of deletions on chromosome 13 in benign and low-malignant lipomatous tumors.
- Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma.
- Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas.
- Ring chromosomes and low-grade gene amplification in an atypical lipomatous tumor with minimal nuclear atypia
- 2002
- A full-coverage, high-resolution human chromosome 22 genomic microarray for clinical and research applications.
- Centrosomal abnormalities, multipolar mitoses, and chromosomal instability in head and neck tumours with dysfunctional telomeres.
- Chromosomal aberrations in benign and malignant Bilharzia-associated bladder lesions analyzed by comparative genomic hybridization.
- Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas
- Correlation between clinicopathological features and karyotype in 100 cartilaginous and chordoid tumours. A report from the Chromosomes and Morphology (CHAMP) Collaborative Study Group
- Cytogenetic aberrations and their prognostic impact in chondrosarcoma.
- Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcoma.
- Establishment and characterisation of a human clear cell sarcoma model in nude mice
- Fusion of RDC1 with HMGA2 in lipomas as the result of chromosome aberrations involving 2q35-37 and 12q13-15.
- Molecular cytogenetic mapping of recurrent chromosomal breakpoints in tenosynovial giant cell tumors.
- Molecular genetic characterization of the EWS/ATF1 fusion gene in clear cell sarcoma of tendons and aponeuroses.
- Molecular genetic characterization of the EWS/CHN and RBP56/CHN fusion genes in extraskeletal myxoid chondrosarcoma.
- Prognostically important chromosomal aberrations in soft tissue sarcomas: a report of the Chromosomes and Morphology (CHAMP) Study Group.
- RNA splicing mediated by YB-1 is inhibited by TLS/CHOP in human myxoid liposarcoma cells
- SYT-SSX is critical for cyclin D1 expression in synovial sarcoma cells: A gain of function of the t(X;18)(p11.2;q11.2) translocation
- 2001
- Abnormal nuclear shape in solid tumors reflects mitotic instability
- Analysis of the distribution and frequency of trisomy 7 in vivo in synovia from patients with osteoarthritis and pigmented villonodular synovitis
- Biallelic inactivation of TP53 rarely contributes to the development of malignant peripheral nerve sheath tumors
- Characterization of chromosomal abnormalities in uroepithelial carcinomas by G-banding, spectral karyotyping and fish analysis
- Clinical impact of molecular and cytogenetic findings in synovial sarcoma
- Cloning of the der(17)t(X;17)(p11;q25) alveolar soft part sarcoma identifies the ASPL-TFE3 gene fusion, a new molecular diagnostic marker
- Cloning of the der(17)t(X;17)(p11;q25) of alveolar soft part sarcoma identifies the ASPL-TFE3 gene fusion, a new molecular diagnostic marker
- Comparative genomic hybridization of postirradiation sarcomas
- DNA copy number amplifications in sarcomas with homogeneously staining regions and double minutes
- Identification of cytogenetic subgroups and karyotypic pathways in transitional cell carcinoma
- Multivariate analyses of genomic imbalances in solid tumors reveal distinct and converging pathways of karyotypic evolution
- No EWS/FLI1 fusion transcripts in giant-cell tumors of bone
- Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors
- The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25
- 2000
- Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity
- Locus-specific multifluor FISH analysis allows physical characterization of complex chromosome abnormalities in neoplasia
- Radiation-associated sarcomas are characterized by complex karyotypes with frequent rearrangements of chromosome arm 3p
- 1999
- Cytogenetic aberrations in Ewing sarcoma: are secondary changes associated with clinical outcome?
- Hibernomas are characterized by homozygous deletions in the multiple endocrine neoplasia type I region. Metaphase fluorescence in situ hybridization reveals complex rearrangements not detected by conventional cytogenetics
- The structure and dynamics of ring chromosomes in human neoplastic and non-neoplastic cells
- Unique cytological features and chromosome aberrations in chondroid lipoma: a case report based on fine-needle aspiration cytology, histopathology, electron microscopy, chromosome banding, and molecular cytogenetics
- Variable stability of chromosomes containing amplified alpha-satellite sequences in human mesenchymal tumours
- 1998
- A case of dermatofibrosarcoma protuberans with a ring chromosome 5 and a rearranged chromosome 22 containing amplified COL1A1 and PDGFB sequences
- Amplification of 12q13 and 12q15 sequences in a sclerosing epithelioid fibrosarcoma
- Chromosomal organization of amplified chromosome 12 sequences in mesenchymal tumors detected by fluorescence in situ hybridization
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- 1986
