Mattias Höglund

författare

• 2012
  • A Molecular Taxonomy for Urothelial Carcinoma.
  • DNA methylation analyses of urothelial carcinoma reveal distinct epigenetic subtypes and an association between gene copy number and methylation status.
  • Integrated genomic and gene expression profiling identifies two major genomic circuits in urothelial carcinoma.
  • Molecular profiling reveals low- and high-grade forms of primary melanoma
  • The Importance of Being Grade 3: WHO 1999 Versus WHO 2004 Pathologic Grading.
  • The bladder cancer genome; chromosomal changes as prognostic makers, opportunities, and obstacles.
• 2011
  • A Systematic Study of Gene Mutations in Urothelial Carcinoma; Inactivating Mutations in TSC2 and PIK3R1
  • A Systematic Study of Gene Mutations in Urothelial Carcinoma; Inactivating Mutations in TSC2 and PIK3R1.
  • Can tissue microarray-based analysis of protein expression predict recurrence of stage Ta bladder cancer?
  • Genotyping techniques to address diversity in tumors.
  • Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene.
• 2010
  • Combined gene expression and genomic profiling define two intrinsic molecular subtypes of urothelial carcinoma and gene signatures for molecular grading and outcome.
  • Genome-wide transcription factor binding site/promoter databases for the analysis of gene sets and co-occurrence of transcription factor binding motifs.
  • Prediction of Stage, Grade, and Survival in Bladder Cancer Using Genome Wide Expression Data: A Validation Study.
  • Robust assignment of cancer subtypes from expression data using a uni-variate gene expression average as classifier
• 2009
  • Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer, a case-control study.
  • MiRNA expression in urothelial carcinomas: Important roles of miR-10a, miR-222, miR-125b, miR-7 and miR-452 for tumor stage and metastasis, and frequent homozygous losses of miR-31.
• 2008
  • Normalization of Illumina Infinium whole-genome SNP data improves copy number estimates and allelic intensity ratios.
  • Promoter analysis of epigenetically controlled genes in bladder cancer.
  • Recurrent and multiple bladder tumors show conserved expression profiles.
  • Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays
  • Tiling resolution array CGH and high density expression profiling of urothelial carcinomas delineate genomic amplicons and candidate target genes specific for advanced tumors.
  • Tissue microarray based analysis of prognostic markers in invasive bladder cancer: Much effort to no avail?
• 2007
  • Bladder cancer, a two phased disease?
  • Distinct Mitotic Segregation Errors Mediate Chromosomal Instability in Aggressive Urothelial Cancers
  • Distinct evolutionary mechanisms for genomic imbalances in high-risk and low-risk neuroblastomas
  • Distinct mitotic segregation errors mediate chromosomal instability in aggressive urothelial cancers.
  • Genetic variant of the human homologous recombination-asociated gene RM11 (S¤%%N) impacts the risk of AML/MDS and malignant melanoma
  • High-resolution genomic profiles of breast cancer cell lines assessed by tiling BAC array comparative genomic hybridization.
  • Microarray-based classification of a consecutive series of 121 childhood acute leukemias: prediction of leukemic and genetic subtype as well as of minimal residual disease status.
  • On the Origin of Syn- and Metachronous Urothelial Carcinomas.
  • Tissye microarray based analysis of prognostic markers in invasive bladder cancer: Much effort to no avail?
• 2006
  • A gene fusion network in human neoplasia.
  • Analysis of promoter regions of co-expressed genes identified by microarray analysis
  • Genomic profiling of bone and soft tissue tumors with supernumerary ring chromosomes using tiling resolution bacterial artificial chromosome microarrays.
  • Independent component analysis reveals new and biologically significant structures in micro array data
  • Independent component analysis reveals new and biologically significant structures in micro array data
  • Meta- and synchronous urothelial carcinomas with divergent genomic profiles show highly similar gene-expression profiles
  • Molecular characterization of early-stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q.
  • New Probabilistic network models and algorithms for oncogenesis
  • Truncation and fusion of HMGA2 in lipomas with rearrangements of 5q32-->q33 and 12q14-->q15.
• 2005
  • Connecting mitotic instability and chromosome aberrations in cancer-can telomeres bridge the gap?
  • Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer.
  • Ewing tumours and synovial sarcomas have critical features of karyotype evolution in common with epithelial tumours.
  • Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations
  • Microarray analyses reveal strong influence of DNA copy number alterations on the transcriptional patterns in pancreatic cancer: implications for the interpretation of genomic amplifications.
  • Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations.
  • Statistical behavior of complex cancer karyotypes.
  • Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity.
  • Telomere-mediated mitotic disturbances in immortalized ovarian epithelial cells reproduce chromosomal losses and breakpoints from ovarian carcinoma
• 2004
  • A model for karyotypic evolution in testicular germ cell tumors.
  • Approximate geodesic distances reveal biologically relevant structures in microarray data
  • Dissecting karyotypic patterns in malignant melanomas: Temporal clustering of losses and gains in melanoma karyotypic evolution.
  • Dissecting karyotypic patterns in renal cell carcinoma: an analysis of the accumulated cytogenetic data.
  • Genome-wide array-based comparative genomic hybridization reveals multiple amplification targets and novel homozygous deletions in pancreatic carcinoma cell lines.
  • High frequencies of chromosomal aberrations in multiple myeloma and monoclonal gammopathy of undetermined significance in direct chromosome preparation.
  • Identification of cytogenetic subgroups and karyotypic pathways of clonal evolution in follicular lymphomas.
  • MDS/AML-associated cytogenetic abnormalities in multiple myeloma and monoclonal gammopathy of undetermined significance: Evidence for frequent de novo occurrence and multipotent stem cell involvement of del(20q).
  • Statistical analyses of karyotypic complexity in head and neck squamous cell carcinoma.
  • Statistical dissection of cytogenetic patterns in lung cancer reveals multiple modes of karyotypic evolution independent of histological classification.
  • Telomere shortening and mitotic dysfunction generate cytogenetic heterogeneity in a subgroup of renal cell carcinomas.
  • The Breakpoint Region of the Most Common Isochromosome, i(17q), in Human Neoplasia Is Characterized by a Complex Genomic Architecture with Large, Palindromic, Low-Copy Repeats.
  • Wilms tumors develop through two distinct karyotypic pathways.
• 2003
  • A Novel Gene, MSI2, Encoding a Putative RNA-binding Protein Is Recurrently Rearranged at Disease Progression of Chronic Myeloid Leukemia and Forms a Fusion Gene with HOXA9 as a Result of the Cryptic t(7;17)(p15;q23).
  • A pooled analysis of karyotypic patterns, breakpoints and imbalances in 783 cytogenetically abnormal multiple myelomas reveals frequently involved chromosome segments as well as significant age- and sex-related differences.
  • Clinical and genetic studies of ETV6/ABL1-positive chronic myeloid leukaemia in blast crisis treated with imatinib mesylate.
  • Clustering of deletions on chromosome 13 in benign and low-malignant lipomatous tumors.
  • Ovarian Carcinoma Develops through Multiple Modes of Chromosomal Evolution.
  • Pancreatic carcinoma cell lines with SMAD4 inactivation show distinct expression responses to TGFB1.
  • Power law distribution of chromosome aberrations in cancer.
  • Vitamin d receptor is expressed in pancreatic cancer cells and a vitamin d(3) analogue decreases cell number.
• 2002
  • Acute myeloid leukemia with inv(16)(p13q22): Involvement of cervical lymph nodes and tonsils is common and may be a negative prognostic sign.
  • Coping with complexity. multivariate analysis of tumor karyotypes.
  • Cyclin D1 amplification in chromosomal band 11q13 is associated with overrepresentation of 3q21-q29 in head and neck carcinomas.
  • Cytogenetic features of multiple myeloma: impact of gender, age, disease phase, culture time, and cytokine stimulation
  • Detailed genomic mapping and expression analyses of 12p amplifications in pancreatic carcinomas reveal a 3.5-Mb target region for amplification.
  • Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcoma.
  • Dissecting karyotypic patterns in colorectal tumors: two distinct but overlapping pathways in the adenoma-carcinoma transition.
  • Frequent amplification of 8q24, 11q, 17q, and 20q-specific genes in pancreatic cancer
  • Molecular cytogenetic mapping of recurrent chromosomal breakpoints in tenosynovial giant cell tumors.
  • Multicolor COBRA-FISH analysis of chronic myeloid leukemia reveals novel cryptic balanced translocations during disease progression.
  • Multivariate analysis of chromosomal imbalances in breast cancer delineates cytogenetic pathways and reveals complex relationships among imbalances.
• 2001
  • Abnormal nuclear shape in solid tumors reflects mitotic instability
  • Altered expression of TGFB receptors and mitogenic effects of TGFB in pancreatic carcinomas
  • Characterization of chromosome aberrations in salivary gland tumors by FISH, including multicolor COBRA-FISH
  • Cytogenetic and fluorescence in situ hybridization characterization of chromosome 8 rearrangements in head and neck squamous cell carcinomas
  • Extensive cytogenetic heterogeneity in a benign retroperitoneal schwannoma
  • Identification of cytogenetic subgroups and karyotypic pathways in transitional cell carcinoma
  • Multivariate analyses of genomic imbalances in solid tumors reveal distinct and converging pathways of karyotypic evolution
  • Paired multiplex reverse-transcriptase polymerase chain reaction (PMRT-PCR) analysis as a rapid and accurate diagnostic tool for the detection of MLL fusion genes in hematologic malignancies
  • Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors
  • The tumor-associated gene HMGIC is expressed in normal and osteoarthritis-affected synovia
• 2000
  • Characterization of genomically amplified segments using PCR: optimizing relative-PCR for reliable and simple gene expression and gene copy analyses
  • Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity
  • Cytogenetic and FISH studies of a single center consecutive series of 152 childhood acute lymphoblastic leukemias
  • Cytogenetics of hepatoblastoma: further characterization of 1q rearrangements by fluorescence in situ hybridization: an international collaborative study
  • Locus-specific multifluor FISH analysis allows physical characterization of complex chromosome abnormalities in neoplasia
  • Putting chromosome aberrations on the map
• 1999
  • Hibernomas are characterized by homozygous deletions in the multiple endocrine neoplasia type I region. Metaphase fluorescence in situ hybridization reveals complex rearrangements not detected by conventional cytogenetics
  • Isochromosome 17q in blast crisis of chronic myeloid leukemia and in other hematologic malignancies is the result of clustered breakpoints in 17p11 and is not associated with coding TP53 mutations
  • The structure and dynamics of ring chromosomes in human neoplastic and non-neoplastic cells
  • Unique cytological features and chromosome aberrations in chondroid lipoma: a case report based on fine-needle aspiration cytology, histopathology, electron microscopy, chromosome banding, and molecular cytogenetics
  • Variable stability of chromosomes containing amplified alpha-satellite sequences in human mesenchymal tumours
• 1998
  • A case of dermatofibrosarcoma protuberans with a ring chromosome 5 and a rearranged chromosome 22 containing amplified COL1A1 and PDGFB sequences
  • Chromosomal organization of amplified chromosome 12 sequences in mesenchymal tumors detected by fluorescence in situ hybridization
  • ETV6/ABL fusion is rare in Ph-negative chronic myeloid disorders
• 1997
  • BCR/ABL-negative chronic myeloid leukemia with ETV6/ABL fusion
• 1996
  • Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS
• 1994
  • Fusion of the FUS gene with ERG in acute myeloid leukemia with t(16;21)(p11;q22)