Per-Olof Grände
Titel
professor/överläkare
046-222 77 53
Per-Olof [dot] Grande [at] med [dot] lu [dot] se
Publikationer (hämtat ur Lunds universitets publikationsdatabas)
författare
- 2013
- Importance of the Infusion Rate for the Plasma Expanding Effect of 5% Albumin, 6% HES 130/0.4, 4% Gelatin, and 0.9% NaCl in the Septic Rat.
- Plasma Volume Expansion by 0.9% NaCl During sepsis/SIRS, After Hemorrhage, and During a Normal State.
- Traumatic Brain Injury: Intracranial pressure monitoring in traumatic brain injury
- Treatment with the sphingosine-1-phosphate analogue FTY 720 reduces loss of plasma volume during experimental sepsis in the rat.
- 2012
- Osmotherapy in brain edema: a questionable therapy.
- Prostacyclin reduces plasma volume loss after skeletal muscle trauma in the rat.
- The G protein-coupled oestrogen receptor 1 agonist G-1 disrupts endothelial cell microtubule structure in a receptor-independent manner.
- The effects of continuous prostacyclin infusion on regional blood flow and cerebral vasospasm following subarachnoid haemorrhage: study protocol for a randomised controlled trial
- 2011
- 2010
- A Model for Evaluating the Effects of Blunt Skeletal Muscle Trauma on Microvascular Permeability and Plasma Volume in the Rat
- Actively induced hypothermia following severe traumatic brain injury
- Critical Aspects on Evaluation of Autoregulation After a Severe Traumatic Brain Injury
- Effects on brain edema of crystalloid and albumin fluid resuscitation after brain trauma and hemorrhage in the rat.
- Segmental cerebral vasoconstriction: successful treatment of secondary cerebral ischaemia with intravenous prostacyclin.
- 2009
- Active cooling in traumatic brain-injured patients: a questionable therapy?
- Comparison of the plasma volume-expanding effects of 6% dextran 70, 5% albumin, and 6% HES 130/0.4 after hemorrhage in the guinea pig.
- Deletion of the G protein-coupled Receptor GPR30 Impairs Glucose Tolerance, Reduces Bone Growth, Increases Blood Pressure, and Eliminates Estradiol-stimulated Insulin Release in Female Mice.
- Do Conventional Treatments of Severe Traumatic Head Injury Worsen Outcome?
- Hemodynamic and histological effects of traumatic brain injury in eNOS-deficient mice.
- Prostacyclin reduces elevation of intracranial pressure and plasma volume loss in lipopolysaccharide-induced meningitis in the cat.
- 2008
- Change in plasma volume from a state of hyper-, normo- or hypovolemia with or without noradrenalin infusion in the rat.
- Effects On Brain Edema Of Crystalloid And Colloid Resuscitation Following Brain Trauma And Hemorrhage In The Rat
- Increased cortical cell loss and prolonged hemodynamic depression after traumatic brain injury in mice lacking the IP receptor for prostacyclin.
- Low-Dose Prostacyclin Attenuates A Decrease In Plasma Volume Following Nonhemorrhagic Trauma In Rats
- The effects of activated protein C and prostacyclin on arterial oxygenation and protein leakage in the lung and the gut under endotoxaemia in the rat.
- Time out for albumin or a valuable therapeutic component in severe head injury?
- 2007
- Conventional treatments for severe head injury: are they effective, ineffective, or even harmful?
- Plasma volume expansion of 5% albumin, 4% gelatin, 6% HES 130/0.4, and normal saline under increased microvascular permeability in the rat.
- The Lund concept: a well-defined therapy within the prescribed norms.
- 2006
- Hypertonic saline: A marker for discrimination between a disrupted and intact blood-brain barrier?
- Plasma volume expansion and transcapillary fluid exchange in skeletal muscle of albumin, dextran, gelatin, hydroxyethyl starch, and saline after trauma in the cat
- Plasma volume expansion and transcapillary fluid exchange in skeletal muscle of albumin, dextran, gelatin, hydroxyethyl starch, and saline after trauma in the cat*
- The "Lund Concept" for the treatment of severe head trauma - physiological principles and clinical application.
- Use of steroids to reduce high fever in head injury-is it acceptable?
- 2005
- Effects on intracranial pressure of dural puncture in supine and head-elevated positions. A study on the cat.
- Mechanisms behind postspinal headache and brain stem compression following lumbar dural puncture - a physiological approach.
- Volume expansion of albumin, gelatin, hydroxyethyl starch, saline and erythrocytes after haemorrhage in the rat.
- 2004
- A mouse model for evaluation of capillary perfusion, microvascular permeability, cortical blood flow, and cortical edema in the traumatized brain.
- Low-dose prostacyclin restores an increased protein permeability after trauma in cat skeletal muscle.
- The permeability-reducing effects of prostacyclin and inhibition of Rho kinase do not counteract endotoxin-induced increase in permeability in cat skeletal muscle.
- Vasopeptidase inhibition with omapatrilat increases fluid and protein microvascular permeability in cat skeletal muscle.
- 2003
- Endogenous Nitric Oxide Reduces Microvascular Permeability and Tissue Oedema during Exercise in Cat Skeletal Muscle.
- Endotoxin increases both protein and fluid microvascular permeability in cat skeletal muscle
- Inhibition of Rho kinase decreases hydraulic and protein microvascular permeability in cat skeletal muscle.
- Low-Dose Prostacyclin Improves Cortical Perfusion following Experimental Brain Injury in the Rat.
- Nitric Oxide and Prostacyclin Play a Role in the Regulation of Microvascular Protein and Hydraulic Permeability in Cat Skeletal Muscle.
- Treatment of traumatic head Injury - US/European guidelines or the lund concept
- 2002
- Clinical studies in severe traumatic brain injury: a controversial issue.
- Effects of hypertonic saline, mannitol, and urea with regard to absorption and rebound filtration in cat skeletal muscle.
- Endothelin-1 Reduces Microvascular Fluid Permeability through Secondary Release of Prostacyclin in Cat Skeletal Muscle.
- Evaluation of capillary perfusion - Reply
- Hypovolemia is a main factor behind disturbed perfusion and metabolism in the intestine during endotoxemia in cat.
- Lund strikes again - Reply
- Treatment of intracranial hypertension and aspects on lumbar dural puncture in severe bacterial meningitis - Reply
- Treatment of intracranial hypertension and aspects on lumbar dural puncture in severe bacterial meningitis.
- Volume-targeted therapy of increased intracranial pressure: the Lund concept unifies surgical and non-surgical treatments
- 2001
- An outcome study of severe traumatic head injury using the "Lund therapy" with low-dose prostacyclin
- Beneficial effects of low-dose prostacyclin on cat intestinal perfusion during endotoxemia as evaluated with microdialysis and oxygen transport variables
- Capillary filtration coefficient is independent of number of perfused capillaries in cat skeletal muscle
- Dextran, gelatin, and hydroxyethyl starch do not affect permeability for albumin in cat skeletal muscle
- Infusion of prostacyclin following experimental brain injury in the rat reduces cortical lesion volume
- 2000
- 1999
- 1995
