Pirkko Härkönen
Titel
Professor
Organisation
Pirkko [dot] Harkonen [at] med [dot] lu [dot] se
Publikationer (hämtat ur Lunds universitets publikationsdatabas)
författare
- 2013
- 2012
- Androgens Inhibit the Stimulatory Action of 17β-Estradiol on Normal Human Breast Tissue in Explant Cultures.
- Fibroblast Growth Factor 8b Causes Progressive Stromal and Epithelial Changes in the Epididymis and Degeneration of the Seminiferous Epithelium in the Testis of Transgenic Mice
- Identification of fibroblast growth factor-8b target genes associated with early and late cell cycle events in breast cancer cells.
- Tracer Level Electrophilic Synthesis and Pharmacokinetics of the Hypoxia Tracer F-18EF5
- 2010
- Down-Regulation of the Oncogene Cyclin D1 Increases Migratory Capacity in Breast Cancer and Is Linked to Unfavorable Prognostic Features.
- Editorial Comment on: Stem Cell Characteristics in Prostate Cancer Cell Lines.
- Fast growth associated with aberrant vasculature and hypoxia in fibroblast growth factor 8b (FGF8b) over-expressing PC-3 prostate tumour xenografts
- Fibroblast growth factor 8 increases breast cancer cell growth by promoting cell cycle progression and by protecting against cell death.
- Fibroblast growth factor 8 induced downregulation of thrombospondin 1 is mediated by the MEK/ERK and PI3K pathways in breast cancer cells
- Immunohistochemical detection of tyrosine phosphatase SHP-1 predicts outcome after radical prostatectomy for localized prostate cancer.
- Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells
- Role of the ProteinTyrosine Phosphatase SHP-I in Interleukin-6 Regulation of Prostate Cancer Cells
- Role of the protein tyrosine phosphatase SHP-1 in Interleukin-6 regulation of prostate cancer cells.
- Stromal Activation Associated with Development of Prostate Cancer in Prostate-Targeted Fibroblast Growth Factor 8b Transgenic Mice
- 2009
- CYCLIN A1 MEDIATES DRUG-RESISTANT METASTATIC SPREAD OF PCA CELLS IN XENOGRAFTS IN VIVO
- EFFECT OF FIBROBLAST GROWTH FACTOR 8 (FGF8B) ON VASCULARISATION AND OXYGENATION OF PC-3 PROSTATE TUMOR XENOGRAFTS
- FGF-8b Induces Growth and Rich Vascularization in an Orthotopic PC-3 Model of Prostate Cancer
- Overexpression of vascular endothelial growth factor C increases growth and alters the metastatic pattern of orthotopic PC-3 prostate tumors
- 2008
- Alendronate decreases orthotopic PC-3 prostate tumor growth and metastasis to prostate-draining lymph nodes in nude mice
- Editorial Comment on: Expression and Prognostic Relevance of Annexin A3 in Prostate Cancer.
- Effects of estradiol and medroxyprogesterone acetate on expression of the cell cycle proteins cyclin D1, p21 and p27 in cultured human breast tissues
- Estrogen and the selective estrogen receptor modulator (SERM) protection against cell death in estrogen receptor alpha and beta expressing U2OS cells
- FGF-8 is involved in bone metastasis of prostate cancer
- Multiple Cellular Mechanisms In Prostate Cancer Invasion And Metastasis
- Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis.
- The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility.
- 2007
- A highly conserved protein secreted by the prostate cancer cell line PC-3 is expressed in benign and malignant prostate tissue.
- Differential effects of selective oestrogen receptor modulators (SERMs) tamoxifen, ospemifene and raloxifene on human osteoclasts in vitro
- Quantitative detection of cell surface protein expression by time-resolved fluorimetry
- Role of fibroblast growth factor 8 in growth and progression of hormonal cancer
- Tamoxifen-induced Rapid Death of MCF-7 Breast Cancer Cells is mediated via ERK Signaling and can be abrogated by Estrogen.
- 2006
- Androgen and fibroblast growth factor 8 (FGF8) downregulation of thrombospondin 1 (TSP1) in mouse breast cancer cells
- Effects of estradiol and medroxyprogesterone acetate on morphology, proliferation and apoptosis of human breast tissue in organ cultures
- Monocyte-macrophage system as a target for estrogen and selective estrogen receptor modulators.
- Regulation of Osteoblast Differentiation - A Novel Function for FGF-8.
- 2005
- Cleavable ErbB4 isoform in estrogen receptor-regulated growth of breast cancer cells
- Effects of ospemifene and raloxifene on hormonal status, lipids, genital tract and tolerability in postmenopausal women
- Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption
- Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis
- Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis
- Estrogen responsiveness of bone formation in vitro and altered bone phenotype in aged estrogen receptor-alpha-deficient male and female mice
- Role of mitochondria in tamoxifen-induced rapid death of MCF-7 breast cancer cells
- Sex specific expression of progesterone receptor in mouse lower urinary tract
- Two-photon excitation in fluorescence polarization receptor-ligand binding assay
- 2004
- 68Ga-labeled oligonucleotides for in vivo imaging with PET
- Comparative study of the short-term effects of a novel selective estrogen receptor modulator, ospemifene, and raloxifene and tamoxifen on rat uterus
- Osteoblast-like cells complete osteoclastic bone resorption and form new mineralized bone matrix in vitro
- Re S. S. Virtanen et al., Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. Cancer Res 2002;62 : 2708-14 - Re K. Sawada et al., Alendronate inhabits lysophosphatidic acid-induced migration of human ovarian cancer cells by attenuating the activation of Rho. Cancer Res 2002;62 : 6015-20 - Reply
- Role of estrogens in development of prostate cancer.
- alpha-Trinositol inhibits FGF-stimulated growth of smooth muscle and breast cancer cells
- 2003
- 2002
- Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway
- Inhibition of cancer cell growth by crude extract and the phenolics of Terminalia chebula retz. fruit
- PRL signal transduction in the epithelial compartment of rat prostate maintained as long-term organ cultures in vitro
- VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors
