Felix Mitelman

författare

• 2012
  • Disease-associated patterns of disomic chromosomes in hyperhaploid neoplasms.
  • Whole-exome sequencing of pediatric acute lymphoblastic leukemia.
• 2010
  • Generation of trisomies in cancer cells by multipolar mitosis and incomplete cytokinesis.
  • The correlation pattern of acquired copy number changes in 164 ETV6/RUNX1-positive childhood acute lymphoblastic leukemias
• 2009
  • Cancer Chromosomes: From Meaningless Noise to Proof of Principle.
• 2008
  • Molecular screening for new fusion genes in cancer
• 2007
  • Response to letter by the ISCN standing committee
  • The impact of translocations and gene fusions on cancer causation.
• 2006
  • A gene fusion network in human neoplasia.
  • A novel and cytogenetically cryptic t(7;21)(p22;q22) in acute myeloid leukemia results in fusion of RUNX1 with the ubiquitin-specific protease gene USP42
• 2005
  • Ewing tumours and synovial sarcomas have critical features of karyotype evolution in common with epithelial tumours.
  • Formation of der(19)t(1;19)(q23;p13) in acute lymphoblastic leukemia.
  • Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations
  • Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations.
  • Prevalence estimates of recurrent balanced cytogenetic aberrations and gene fusions in unselected patients with neoplastic disorders.
  • Statistical behavior of complex cancer karyotypes.
  • Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity.
• 2004
  • A model for karyotypic evolution in testicular germ cell tumors.
  • Clinical and biological importance of cytogenetic abnormalities in childhood and adult acute lymphoblastic leukemia.
  • Clinical impact of internal tandem duplications and activating point mutations in FLT3 in acute myeloid leukemia in elderly patients.
  • Dissecting karyotypic patterns in malignant melanomas: Temporal clustering of losses and gains in melanoma karyotypic evolution.
  • Dissecting karyotypic patterns in renal cell carcinoma: an analysis of the accumulated cytogenetic data.
  • Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer.
  • High frequencies of chromosomal aberrations in multiple myeloma and monoclonal gammopathy of undetermined significance in direct chromosome preparation.
  • Identification of a commonly amplified 4.3 Mb region with overexpression of the C8FW gene, encoding a phosphoprotein regulated by mitogenic pathways, but not of the MYC gene in MYC-containing double minutes in myeloid malignancies.
  • Identification of cytogenetic subgroups and karyotypic pathways of clonal evolution in follicular lymphomas.
  • MDS/AML-associated cytogenetic abnormalities in multiple myeloma and monoclonal gammopathy of undetermined significance: Evidence for frequent de novo occurrence and multipotent stem cell involvement of del(20q).
  • MLL/GRAF fusion in an infant acute monocytic leukemia (AML M5b) with a cytogenetically cryptic ins(5;11)(q31;q23q23).
  • Statistical analyses of karyotypic complexity in head and neck squamous cell carcinoma.
  • Statistical dissection of cytogenetic patterns in lung cancer reveals multiple modes of karyotypic evolution independent of histological classification.
  • The Breakpoint Region of the Most Common Isochromosome, i(17q), in Human Neoplasia Is Characterized by a Complex Genomic Architecture with Large, Palindromic, Low-Copy Repeats.
  • Tumor karyotype predicts clinical outcome in colorectal cancer patients
  • Wilms tumors develop through two distinct karyotypic pathways.
• 2003
  • A Novel Gene, MSI2, Encoding a Putative RNA-binding Protein Is Recurrently Rearranged at Disease Progression of Chronic Myeloid Leukemia and Forms a Fusion Gene with HOXA9 as a Result of the Cryptic t(7;17)(p15;q23).
  • A pooled analysis of karyotypic patterns, breakpoints and imbalances in 783 cytogenetically abnormal multiple myelomas reveals frequently involved chromosome segments as well as significant age- and sex-related differences.
  • Clinical and genetic studies of ETV6/ABL1-positive chronic myeloid leukaemia in blast crisis treated with imatinib mesylate.
  • Cytogenetic and Molecular Genetic Evolution of Philadelphia-Chromosome-Positive Chronic Myeloid Leukaemia
  • Cytogenetic and morphologic subgroups of myelodysplastic syndromes in relation to occupational and hobby exposures.
  • Formation of trisomies and their parental origin in hyperdiploid childhood acute lymphoblastic leukemia.
  • Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13).
  • Genomic characterization of MOZ/CBP and CBP/MOZ chimeras in acute myeloid leukemia suggests the involvement of a damage-repair mechanism in the origin of the t(8;16)(p11;p13).
  • Ovarian Carcinoma Develops through Multiple Modes of Chromosomal Evolution.
  • Power law distribution of chromosome aberrations in cancer.
• 2002
  • Acute myeloid leukemia with inv(16)(p13q22): Involvement of cervical lymph nodes and tonsils is common and may be a negative prognostic sign.
  • Coping with complexity. multivariate analysis of tumor karyotypes.
  • Correlation between clinicopathological features and karyotype in 100 cartilaginous and chordoid tumours. A report from the Chromosomes and Morphology (CHAMP) Collaborative Study Group
  • Cytogenetic and molecular genetic evolution of chronic myeloid leukemia.
  • Cytogenetic features of multiple myeloma: impact of gender, age, disease phase, culture time, and cytokine stimulation
  • Dissecting karyotypic patterns in colorectal tumors: two distinct but overlapping pathways in the adenoma-carcinoma transition.
  • Expression of NUP98/TOP1, but not of TOP1/NUP98, in a treatment-related myelodysplastic syndrome with t(10;20;11)(q24;q11;p15).
  • Multicolor COBRA-FISH analysis of chronic myeloid leukemia reveals novel cryptic balanced translocations during disease progression.
  • Multivariate analysis of chromosomal imbalances in breast cancer delineates cytogenetic pathways and reveals complex relationships among imbalances.
  • Pooled analysis of clinical and cytogenetic features in treatment-related and de novo adult acute myeloid leukemia and myelodysplastic syndromes based on a consecutive series of 761 patients analyzed 1976-1993 and on 5098 unselected cases reported in the literature 1974-2001.
  • Prognostic implications of BCL6 rearrangement in uniformly treated patients with diffuse large B-cell lymphoma--a Nordic Lymphoma Group study.
  • Prognostically important chromosomal aberrations in soft tissue sarcomas: a report of the Chromosomes and Morphology (CHAMP) Study Group.
  • RT-PCR analysis of acute myeloid leukemia with t(8;16)(p11;p13): Identification of a novel MOZ/CBP transcript and absence of CBP/MOZ expression.
  • Unique balanced chromosome abnormalities in treatment-related myelodysplastic syndromes and acute myeloid leukemia: Report from an international workshop
• 2001
  • Are occupational, hobby, or lifestyle exposures associated with Philadelphia chromosome positive chronic myeloid leukaemia?
  • Characterization of chromosome aberrations in salivary gland tumors by FISH, including multicolor COBRA-FISH
  • Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: the first fusion gene involving BCR but not ABL
  • Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13)
  • Identification of cytogenetic subgroups and karyotypic pathways in transitional cell carcinoma
  • Isodicentric 7p, idic(7)(q11.2), in acute myeloid
  • Multivariate analyses of genomic imbalances in solid tumors reveal distinct and converging pathways of karyotypic evolution
  • Paired multiplex reverse-transcriptase polymerase chain reaction (PMRT-PCR) analysis as a rapid and accurate diagnostic tool for the detection of MLL fusion genes in hematologic malignancies
  • Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors
  • The incidence of trisomy 8 as a sole chromosomal aberration in myeloid malignancies varies in relation to gender, age, prior iatrogenic genotoxic exposure, and morphology
  • The prognostic impact of karyotypic subgroups in myelodysplastic syndromes is strongly modified by sex
• 2000
  • Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity
  • Cytogenetic and FISH studies of a single center consecutive series of 152 childhood acute lymphoblastic leukemias
  • Granulocytic sarcomas in body cavities in childhood acute myeloid leukemias with 11q23/MLL rearrangements
  • RT-PCR analysis of the MOZ-CBP and CBP-MOZ chimeric transcripts in acute myeloid leukemias with t(8;16)(p11;p13)
  • Radiation-associated sarcomas are characterized by complex karyotypes with frequent rearrangements of chromosome arm 3p
  • Survival time in a population-based consecutive series of adult acute myeloid leukemia--the prognostic impact of karyotype during the time period 1976-1993
• 1999
  • A single-center population-based consecutive series of 1500 cytogenetically investigated adult hematological malignancies: karyotypic features in relation to morphology, age and gender
  • Cytogenetic polyclonality in hematologic malignancies
  • Isochromosome 17q in blast crisis of chronic myeloid leukemia and in other hematologic malignancies is the result of clustered breakpoints in 17p11 and is not associated with coding TP53 mutations
  • Prognostic implications of cytogenetic aberrations in diffuse large B-cell lymphomas
  • The structure and dynamics of ring chromosomes in human neoplastic and non-neoplastic cells
• 1998
  • Chromosomal organization of amplified chromosome 12 sequences in mesenchymal tumors detected by fluorescence in situ hybridization
  • ETV6/ABL fusion is rare in Ph-negative chronic myeloid disorders
  • Frequent rearrangements of chromosomes 1, 7, and 8 in primary liver cancer
• 1997
  • BCR/ABL-negative chronic myeloid leukemia with ETV6/ABL fusion
  • Cytogenetic abnormalities and clonal evolution in an adult hepatoblastoma
  • Monosomy 22 in a case of biliary adenofibroma
  • Poor survival in t(8;21) (q22;q22)-associated acute myeloid leukaemia with leukocytosis
• 1996
  • Abberant cytogenetic evolution pattern of Philadelphia-positive chronic myeloid leukemia treated with interferon-alpha
  • Chromosome aberrations in prophylactic mastectomies from women belonging to breast cancer families
  • Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS
  • t(3;21)(q26;q22) with AML1 rearrangement in a de novo childhood acute monoblastic leukaemia
• 1994
  • Fusion of the FUS gene with ERG in acute myeloid leukemia with t(16;21)(p11;q22)
• 1993
  • Clinical impact of breakpoint position within M-bcr in chronic myeloid leukemia
  • Comparative cytogenetic and DNA flow cytometric analysis of 150 bone and soft-tissue tumors
  • Cytogenetic findings in 33 osteosarcomas
• 1992
  • Chromosome aberrations in 35 primary ovarian carcinomas
  • Molecular analysis of Philadelphia-positive childhood chronic myeloid leukemia.
  • Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11)
• 1991
  • New chromosomal rearrangement, t(12;22)(p13;q12), in acute nonlymphocytic leukemia
• 1990
  • Bone marrow karyotypes in 94 children with acute leukemia
  • Complex karyotypic changes, including rearrangements of 12q13 and 14q24, in two leiomyosarcomas
  • Remarkably long survival of a patient with Ph1-positive chronic myeloid leukemia and 5' bcr rearrangement
• 1989
  • Complex karyotypic anomalies in a bizarre leiomyoma of the uterus.
• 1987
  • A new specific chromosomal rearrangement, t(8;16) (p11;p13), in acute monocytic leukaemia
  • New structural chromosomal rearrangements in congenital leukemia
• 1986
  • High resolution banding analysis of the reciprocal translocation t(6;9) in acute nonlymphocytic leukemia
  • Reciprocal translocation (11;19)(q23;p13) in congenital acute lymphoblastic leukemia
• 1984
  • First-trimester diagnosis on chorionic villi obtained by direct vision technique
• 1983
  • Diagnostisk korionbiopsi vid Lasarettet i Lund