Fredrik Mertens
Titel
professor, avdelningsföreträdare
Organisation
046-173387
Fredrik [dot] Mertens [at] med [dot] lu [dot] se
Publikationer (hämtat ur Lunds universitets publikationsdatabas)
författare
- 2013
- 2012
- A novel GTF2I/NCOA2 fusion gene emphasizes the role of NCOA2 in soft tissue angiofibroma development.
- Analysis of giant cell tumour of bone cells for Noonan syndrome/Cherubism-related mutations.
- Biphasic, Hyperdiploid Breast Tumors in Children: A Distinct Entity?
- Disease-associated patterns of disomic chromosomes in hyperhaploid neoplasms.
- FOSL1 as a candidate target gene for 11q12 rearrangements in desmoplastic fibroblastoma.
- Fusion of the AHRR and NCOA2 genes through a recurrent translocation t(5;8)(p15;q13) in soft tissue angiofibroma results in upregulation of aryl hydrocarbon receptor target genes.
- Homozygous deletions of cadherin genes in chondrosarcoma-an array comparative genomic hybridization study
- Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data
- MUC4 Is a Sensitive and Extremely Useful Marker for Sclerosing Epithelioid Fibrosarcoma: Association With FUS Gene Rearrangement.
- Malignant fibrous histiocytoma and fibrosarcoma of bone: a re-assessment in the light of currently employed morphological, immunohistochemical and molecular approaches
- Molecular genetic characterization of the 11q13 breakpoint in a desmoplastic fibroma of bone
- Recurrent Rearrangement of the PHF1 Gene in Ossifying Fibromyxoid Tumors.
- Retained heterodisomy is associated with high gene expression in hyperhaploid inflammatory leiomyosarcoma.
- SNP array and FISH findings in two pleomorphic hyalinizing angiectatic tumors.
- Smooth muscle actin expression in primary bone tumours
- The MDM2 SNP309 G allele is not preferentially amplified in bone and soft tissue tumors.
- 2011
- Chromosome banding analysis of cells from fine-needle aspiration biopsy samples from soft tissue and bone tumors: is it clinically meaningful?
- FUS-CREB3L2/L1-Positive Sarcomas Show a Specific Gene Expression Profile with Upregulation of CD24 and FOXL1.
- Gene expression and single nucleotide polymorphism array analyses of spindle cell lipomas and conventional lipomas with 13q14 deletion.
- HMGA2 and MDM2 expression in lipomatous tumors with partial, low-level amplification of sequences from the long arm of chromosome 12.
- Identification of a Novel, Recurrent HEY1-NCOA2 Fusion in Mesenchymal Chondrosarcoma Based on a Genome-Wide Screen of Exon-Level Expression Data
- MUC4 Is a Highly Sensitive and Specific Marker for Low-Grade Fibromyxoid Sarcoma
- MUC4 Is a Highly Sensitive and Specific Marker for Low-grade Fibromyxoid Sarcoma.
- Malignant Fibrous Histiocytoma and Fibrosarcoma of Bone in 2011: What's New?
- Mesenchymal stromal cells from primary osteosarcoma are non-malignant and strikingly similar to their bone marrow counterparts.
- Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study
- The t(X;6) in subungual exostosis results in transcriptional deregulation of the gene for insulin receptor substrate 4.
- Translocation t(7;19)(q22;q13)-a recurrent chromosome aberration in pseudomyogenic hemangioendothelioma?
- Tumor-Infiltrating Macrophages Are Associated with Metastasis Suppression in High-Grade Osteosarcoma: A Rationale for Treatment with Macrophage Activating Agents
- Tumor-Infiltrating Macrophages Are Associated with Metastasis Suppression in High-Grade Osteosarcoma: A Rationale for Treatment with Macrophage-Activating Agents
- 2010
- Characterization of an alternative transcript of the human CREB3L2 gene.
- Concomitant deletions of tumor suppressor genes MEN1 and AIP are essential for the pathogenesis of the brown fat tumor hibernoma.
- Epigenetic target genes in malignant peripheral nerve sheath tumours identified as surrogate prognostic biomarkers
- Fusion of the FUS and CREB3L2 genes in a supernumerary ring chromosome in low-grade fibromyxoid sarcoma.
- Generation of trisomies in cancer cells by multipolar mitosis and incomplete cytokinesis.
- Genetic Abnormalities of the Transcription Factor T (Brachyury) in Sporadic Chordomas
- Genomic Changes in Chromosomes 10, 16, and X in Malignant Peripheral Nerve Sheath Tumors Identify a High-Risk Patient Group.
- Genomic characteristics of soft tissue sarcomas.
- Heterogeneous and Complex Rearragements of the Long Arm of Chromosome 6 in Chondromyxoid Fibroma
- Heterogeneous and Complex Rearragements of the Long Arm of Chromosome 6 in Chondromyxoid Fibroma
- Heterogeneous and Complex Rearrangements of Chromosome Arm 6q in Chondromyxoid Fibroma. Delineation of Breakpoints and Analysis of Candidate Target Genes.
- In Vivo and In Vitro Implications of the Transcription Factor T (Brachyury) in Pathogenesis of Sporadic Chordomas
- Prognostic value of gene expression targeted by gain of 17q sequences in malignant peripheral nerve sheath tumours
- 2009
- Balanced and Unbalanced Rearrangement of Chromosome Arm 6q in Chondromyxoid Fibroma (CMF): Delineation of Breakpoints and Analysis of Candidate Target Genes
- Bidirectionality and transcriptional activity of the EWSR1 promoter region.
- Characterization of a Hotspot Region on Chromosome 12 for Amplification in Ring Chromosomes in Atypical Lipomatous Tumors
- Characterization of the human CREB3L2 gene promoter.
- Clonal chromosome aberrations in a sialoblastoma
- Comparison of cisplatin sensitivity and the 18F fluoro-2-deoxy 2 glucose uptake with proliferation parameters and gene expression in squamous cell carcinoma cell lines of the head and neck
- Cytogenetic Analysis of 101 Giant Cell Tumors of Bone: Nonrandom Patterns of Telomeric Associations and Other Structural Aberrations
- Expression levels of HMGA2 in adipocytic tumors correlate with morphologic and cytogenetic subgroups.
- Genomic profiling of chondrosarcoma: chromosomal patterns in central and peripheral tumors.
- Germline and somatic NF1 mutations in sporadic and NF1-associated malignant peripheral nerve sheath tumours
- Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors
- Low-grade fibromyxoid sarcoma is difficult to diagnose by fine needle aspiration cytology: a cytomorphological study of eight cases.
- Molecular Characterization Of The 12Q13.3-14.1 Recurrent Breakpoint Region On Ring Chromosomes 12 In Atypical Lipomatous Tumors
- No Genomic Aberrations in Langerhans Cell Histiocytosis as Assessed by Diverse Molecular Technologies
- Telomeric associations correlate with telomere length reduction and clonal chromosome aberrations in giant cell tumor of bone.
- Translocation-related sarcomas.
- Two genetic pathways, t(1;10) and amplification of 3p11-12, in myxoinflammatory fibroblastic sarcoma, haemosiderotic fibrolipomatous tumour, and morphologically similar lesions.
- 2008
- A PCR/restriction digestion assay for the detection of the transcript variants 1 and 2 of POU5F1.
- An endometrial stromal sarcoma cell line with the JAZF1/PHF1 chimera.
- Cytogenetic and molecular cytogenetic findings in lipoblastoma.
- Deep-seated ordinary and atypical lipomas - Histopathology, cytogenetics, clinical features, and outcome in 215 tumours of the extremity and trunk wall
- Frequent deletion of the CDKN2A locus in chordoma: analysis of chromosomal imbalances using array comparative genomic hybridisation.
- Fusion of the COL1A1 and USP6 genes in a benign bone tumor.
- Heterogeneous genetic profiles in soft tissue myoepitheliomas
- Heterogeneous genetic profiles in soft tissue myoepitheliomas.
- High-resolution molecular cytogenetic analysis of Wilms tumors highlights diagnostic difficulties among small round cell kidney tumors.
- Increased sensitivity to bleomycin in upper aerodigestive tract mucosa of head and neck squamous cell carcinoma patients.
- Mesenchymal Stromal Cells (MSC) Isolated from Human Osteosarcomas Show a High Progenitor Cell Frequency, Typical MSC Morphology, Surface Marker Profile, and Differentiation Capacity, and They Are Considerably Affected by Tyrosine Kinase Inhibitors in Vitro
- Molecular identification of COL6A3-CSF1 fusion transcripts in tenosynovial giant cell tumors
- POU5F1, encoding a key regulator of stem cell pluripotency, is fused to EWSR1 in hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands.
- Selection of Influential Genetic Markers Among a Large Number of Candidates Based on Effect Estimation Rather than Hypothesis Testing: An Approach for Genome-Wide Association Studies.
- The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1.
- The utility of fluorescence in situ hybridization (FISH) in the diagnosis of myxoid soft tissue neoplasms
- 2007
- Assessment of the clinical and molecular impact of different cytogenetic subgroups in a series of 272 lipomas with abnormal karyotype.
- Assessment of the clinical and molecular impact of different cytogenetic subgroups in a series of 272 lipomas with abnormal karyotype.
- Characterization of the native CREB3L2 transcription factor and the FUS/CREB3L2 chimera.
- Comparison of the proximal promoter regions of the PAX3 and PAX7 genes
- Concurrent gain of 17q and the MYC oncogene in a medullomyoblastoma
- Cytogenetic findings in pediatric renal cell carcinoma
- Fusion genes in angiomatoid fibrous histiocytoma
- Genetic intratumour heterogeneity in high-grade brain tumours is associated with telomere-dependent mitotic instability.
- Successful treatment of a child with t(15;19)-positive tumor.
- The impact of translocations and gene fusions on cancer causation.
- Tiling resolution array comparative genomic hybridization analysis of a fibrosarcoma of bone.
- Unstable translocation (8;22) in a case of giant cell reparative granuloma
- Unstable translocation (8;22) in a case of giant cell reparative granuloma.
- 2006
- Cytogenetic abnormalities in 106 oral squamous cell carcinomas.
- Expression profiling of Wilms tumors reveals new candidate genes for different clinical parameters
- FISH mapping of i(7q) in acute leukemias and myxoid liposarcoma reveals clustered breakpoints in 7p11.2: implications for formation and pathogenetic outcome of the idic(7)(p11.2).
- Fine-needle aspiration of neurilemoma (schwannoma). A clinicocytopathologic study of 116 patients.
- Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor.
- Fusion of the Tumor-Suppressor Gene CHEK2 and the Gene for the Regulatory Subunit B of Protein Phosphatase 2 PPP2R2A in Childhood Teratoma.
- Gene copy number changes in dermatofibrosarcoma protuberans - a fine-resolution study using array comparative genomic hybridization
- Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma
- Genomic profiling of bone and soft tissue tumors with supernumerary ring chromosomes using tiling resolution bacterial artificial chromosome microarrays.
- Identification of a novel amplicon at distal 17q containing the BIRC5/SURVIVIN gene in malignant peripheral nerve sheath tumours
- Molecular cytogenetic characterization of the 11q13 amplicon in head and neck squamous cell carcinoma.
- Prognostic Significance of Chromosome Aberrations in High-Grade Soft Tissue Sarcomas.
- Rearrangement of the COL12A1 and COL4A5 genes in subungual exostosis: molecular cytogenetic delineation of the tumor-specific translocation t(X;6)(q13-14;q22)
- Truncation and fusion of HMGA2 in lipomas with rearrangements of 5q32-->q33 and 12q14-->q15.
- 2005
- Absence of mutations of the BRAF gene in malignant melanoma of soft parts (clear cell sarcoma of tendons and aponeuroses).
- Atypical lipomatous tumor with rare structural rearrangements involving chromosomes 8 and 12.
- Biallelic somatic inactivation of the NF1 gene through chromosomal translocations in a sporadic neurofibroma
- Clear cell hidradenoma of the skin - a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion
- Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene.
- Core-needle biopsy performed by the cytopathologist - A technique to complement fine-needle aspiration of soft tissue and bone lesions
- Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma.
- Fusion of the HMGA2 and NFIB genes in lipoma.
- Karyotypic evolution and tumor progression in head and neck squamous cell carcinomas.
- Molecular cytogenetic characterization of an ins(4;X) occurring as the sole abnormality in an aggressive, poorly differentiated soft tissue sarcoma.
- Prevalence estimates of recurrent balanced cytogenetic aberrations and gene fusions in unselected patients with neoplastic disorders.
- Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity.
- 2004
- A novel FISH assay for SS18-SSX fusion type in synovial sarcoma.
- Activation of the GLI Oncogene through Fusion with the beta-Actin Gene (ACTB) in a Group of Distinctive Pericytic Neoplasms: Pericytoma with t(7;12).
- Amplification of chromosome 1 sequences in lipomatous tumors and other sarcomas.
- Clinical and biological importance of cytogenetic abnormalities in childhood and adult acute lymphoblastic leukemia.
- Combined binary ratio labeling fluorescence in situ hybridization analysis of chordoma.
- Expression of DOL54 is not restricted to myxoid liposarcomas with the FUS-DDIT3 chimera but is found in various sarcomas.1
- Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer.
- Genetic characterization of bone and soft tissue tumors
- Mitotic instability associated with late genomic changes in bone and soft tissue tumours.
- Molecular cytogenetic characterization of recurrent translocation breakpoints in bizarre parosteal osteochondromatous proliferation (Nora's lesion).
- Molecular genetic characterization of the genomic ACTB-GLI fusion in pericytoma with t(7;12).
- Retained heterodisomy for chromosome 12 in atypical lipomatous tumors: implications for ring chromosome formation.
- Statistical analyses of karyotypic complexity in head and neck squamous cell carcinoma.
- 2003
- A novel fusion gene, SS18L1/SSX1, in synovial sarcoma.
- Clustering of deletions on chromosome 13 in benign and low-malignant lipomatous tumors.
- Comparative cytogenetic and DNA flow cytometric analysis of 242 primary breast carcinomas
- Cytogenetic findings and clinical course in a consecutive series of Wilms tumors.
- Extraskeletal myxoid chondrosarcoma with neuroendocrine differentiation: a case report with fine-needle aspiration biopsy, histopathology, electron microscopy, and cytogenetics.
- Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma.
- Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas.
- Ring chromosomes and low-grade gene amplification in an atypical lipomatous tumor with minimal nuclear atypia
- Topoisomerase-II alpha is upregulated in malignant peripheral nerve sheath tumors and associated with clinical outcome
- 2002
- Centrosomal abnormalities, multipolar mitoses, and chromosomal instability in head and neck tumours with dysfunctional telomeres.
- Chordoma
- Chromosomal translocations involving 11q13 contribute to cyclin D1 overexpression in squamous cell carcinoma of the head and neck.
- Congenital and inherited syndromes associated with bone and soft tissue tumours
- Correlation between clinicopathological features and karyotype in 100 cartilaginous and chordoid tumours. A report from the Chromosomes and Morphology (CHAMP) Collaborative Study Group
- Cyclin D1 amplification in chromosomal band 11q13 is associated with overrepresentation of 3q21-q29 in head and neck carcinomas.
- Cytogenetic aberrations and their prognostic impact in chondrosarcoma.
- Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcoma.
- Enchondromatosis: Ollier disease and Maffucci syndrome
- Fusion of RDC1 with HMGA2 in lipomas as the result of chromosome aberrations involving 2q35-37 and 12q13-15.
- Karyotypic heterogeneity and clonal evolution in squamous cell carcinomas of the head and neck.
- Molecular cytogenetic mapping of recurrent chromosomal breakpoints in tenosynovial giant cell tumors.
- Molecular genetic characterization of the EWS/ATF1 fusion gene in clear cell sarcoma of tendons and aponeuroses.
- Molecular genetic characterization of the EWS/CHN and RBP56/CHN fusion genes in extraskeletal myxoid chondrosarcoma.
- Prognostically important chromosomal aberrations in soft tissue sarcomas: a report of the Chromosomes and Morphology (CHAMP) Study Group.
- Solid tumor cytogenetics
- Synovial chondromatosis
- 2001
- Abnormal nuclear shape in solid tumors reflects mitotic instability
- Analysis of the distribution and frequency of trisomy 7 in vivo in synovia from patients with osteoarthritis and pigmented villonodular synovitis
- Biallelic inactivation of TP53 rarely contributes to the development of malignant peripheral nerve sheath tumors
- Calcium pyrophosphate dihydrate crystal deposition disease in the temporomandibular joint: Diagnostic difficulties and clonal chromosome aberrations in a case followed up for 5 years
- Characterization of chromosome aberrations in salivary gland tumors by FISH, including multicolor COBRA-FISH
- Clinical impact of molecular and cytogenetic findings in synovial sarcoma
- Cloning of the der(17)t(X;17)(p11;q25) alveolar soft part sarcoma identifies the ASPL-TFE3 gene fusion, a new molecular diagnostic marker
- Comparative genomic hybridization of postirradiation sarcomas
- Cytogenetic and fluorescence in situ hybridization characterization of chromosome 8 rearrangements in head and neck squamous cell carcinomas
- DNA copy number amplifications in sarcomas with homogeneously staining regions and double minutes
- Distinct cytologic features of spindle cell lipoma - A cytologic-histologic study with clinical, radiologic, electron microscopic, and cytogenetic correlations
- Multivariate analyses of genomic imbalances in solid tumors reveal distinct and converging pathways of karyotypic evolution
- No EWS/FLI1 fusion transcripts in giant-cell tumors of bone
- Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors
- The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25
- The tumor-associated gene HMGIC is expressed in normal and osteoarthritis-affected synovia
- Trisomy 7 accumulates with age in solid tumors and non-neoplastic synovia
- 2000
- Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity
- Cytogenetic heterogeneity and clonal evolution in synchronous bilateral breast carcinomas and their lymph node metastases from a male patient without any detectable BRCA2 germline mutation
- Cytogenetics of hepatoblastoma: further characterization of 1q rearrangements by fluorescence in situ hybridization: an international collaborative study
- Radiation-associated sarcomas are characterized by complex karyotypes with frequent rearrangements of chromosome arm 3p
- 1999
- Chromosomal aberrations in breast cancer: a comparison between cytogenetics and comparative genomic hybridization
- Cytogenetic aberrations in Ewing sarcoma: are secondary changes associated with clinical outcome?
- Hibernomas are characterized by homozygous deletions in the multiple endocrine neoplasia type I region. Metaphase fluorescence in situ hybridization reveals complex rearrangements not detected by conventional cytogenetics
- The structure and dynamics of ring chromosomes in human neoplastic and non-neoplastic cells
- Unique cytological features and chromosome aberrations in chondroid lipoma: a case report based on fine-needle aspiration cytology, histopathology, electron microscopy, chromosome banding, and molecular cytogenetics
- Variable stability of chromosomes containing amplified alpha-satellite sequences in human mesenchymal tumours
- 1998
- A case of dermatofibrosarcoma protuberans with a ring chromosome 5 and a rearranged chromosome 22 containing amplified COL1A1 and PDGFB sequences
- Amplification of 12q13 and 12q15 sequences in a sclerosing epithelioid fibrosarcoma
- Chromosomal organization of amplified chromosome 12 sequences in mesenchymal tumors detected by fluorescence in situ hybridization
- Complex karyotypes in flow cytometrically DNA-diploid squamous cell carcinomas of the head and neck
- 1996
- 1993
- 1990
