Lennart Truedsson

författare

• 2013
  • Increased serum type I interferon activity in early systemic sclerosis patients is associated with antibodies against Sjögren's syndrome antigens and nuclear ribonucleoprotein antigens.
  • Low diagnostic and predictive value of anti-dsDNA antibodies in unselected patients with recent onset of rheumatic symptoms: results from a long-term follow-up Scandinavian multicentre study.
• 2012
  • Combination of Autoantibodies Against Different Histone Proteins Influences Complement-dependent Phagocytosis of Necrotic Cell Material by Polymorphonuclear Leukocytes in Systemic Lupus Erythematosus.
  • Complement in the immunopathogenesis of rheumatic disease.
  • Fine mapping and conditional analysis identify a new mutation in the autoimmunity susceptibility gene BLK that leads to reduced half-life of the BLK protein
  • Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene
  • IgG glycan hydrolysis by EndoS diminishes the pro-inflammatory properties of immune complexes from patients with SLE - a possible new treatment?
  • IgG glycan hydrolysis by endoglycosidase S diminishes the proinflammatory properties of immune complexes from patients with systemic lupus erythematosus: A possible new treatment?
  • Increased C1q, C4 and C3 deposition on platelets in patients with systemic lupus erythematosus - a possible link to venous thrombosis?
  • Increased IgG on cell-derived plasma microparticles in systemic lupus erythematosus is associated with autoantibodies and complement activation.
  • Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease.
  • Sensitive and specific assays for C3 nephritic factors clarify mechanisms underlying complement dysregulation
  • The effect of smoking and alcohol consumption on markers of systemic inflammation, immunoglobulin levels and immune response following pneumococcal vaccination in patients with arthritis
  • Vaccination against encapsulated bacteria in hereditary C2 deficiency results in antibody response and opsonization due to antibody-dependent complement activation.
• 2011
  • A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE
  • Antibody response is reduced following vaccination with 7-valent conjugate pneumococcal vaccine in adult methotrexate-treated patients with established arthritis, but not those treated with tumor necrosis factor inhibitors
  • Complement deficiency states and associated infections.
  • Heptavalent pneumococcal conjugate vaccine elicits similar antibody response as standard 23-valent polysaccharide vaccine in adult patients with RA treated with immunomodulating drugs.
  • Increased cartilage turnover and circulating autoantibodies in different subsets before the clinical onset of rheumatoid arthritis.
  • Methotrexate but not TNF-blockers reduces antibody response following pneumococcal vaccination using 7-valent conjugate pneumococcal vaccine in adult patients with established arthritis.
  • Molecular basis of hereditary C1q deficiency-revisited: identification of several novel disease-causing mutations
  • Molecular characterization of two novel cases of complete complement inhibitor Factor I deficiency.
  • Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus
  • Protein synthesis of the pro-inflammatory S100A8/A9 complex in plasmacytoid dendritic cells and cell surface S100A8/A9 on leukocyte subpopulations in systemic lupus erythematosus
• 2010
  • A 3 '-Untranslated Region Variant Is Associated With Impaired Expression of CD226 in T and Natural Killer T Cells and Is Associated With Susceptibility to Systemic Lupus Erythematosus
  • Expression of activation markers on eosinophils in patients with systemic sclerosis
  • Homozygosity For a Novel Mutation in the C1q C Chain Gene in a Turkish Family With Hereditary C1q Deficiency
  • Impaired opsonization with complement and phagocytosis of Streptococcus pyogenes in sera from subjects with inherited C2 deficiency
  • Platelet transcriptional profile and protein expression in patients with systemic lupus erythematosus: up-regulation of the type I interferon system is strongly associated with vascular disease.
  • Recombinant human complement component C2 produced in a human cell line restores the classical complement pathway activity in-vitro: an alternative treatment for C2 deficiency diseases
  • Sensitive and specific assays for C3 nephritic factors permit dissection of mechanisms underlying complement dysregulation
  • Toll-Like Receptor 4 Promoter Polymorphisms: Common TLR4 Variants May Protect against Severe Urinary Tract Infection.
• 2009
  • Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjogren's syndrome
  • C1q Inhibits Immune Complex-Induced Interferon-alpha Production in Plasmacytoid Dendritic Cells A Novel Link Between C1q Deficiency and Systemic Lupus Erythematosus Pathogenesis
  • C1q inhibits immune complex induced IFN-alpha production in plasmacytoid dendritic cells-A novel link between C1q deficiency and SLE pathogenesis
  • C1q inhibits immune complex-induced interferon-alpha production in plasmacytoid dendritic cells: A novel link between C1q deficiency and systemic lupus erythematosus pathogenesis.
  • Complement classical pathway components are all important in clearance of apoptotic and secondary necrotic cells.
  • Genetic, molecular and functional analyses of complement factor I deficiency.
  • Influence of IgG allotypes on defense against Haemophilus influenzae type b in children-A complement-dependent mechanism?
  • Mannose-binding lectin as a risk factor for acute coronary syndromes.
  • Mitochondrial DNA polymorphisms are associated with susceptibility and phenotype of systemic lupus erythematosus.
  • Neutrophil degranulation and complement release in ANCA-associated vasculitis: an in vitro study
  • Persulphate challenge in female hairdressers with nasal hyperreactivity suggests immune cell, but no IgE reaction.
• 2008
  • A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5
  • Amerindian ancestry in Argentina is associated with increased risk for systemic lupus erythematosus
  • Complement classical pathway components are all important in clearance of apoptotic cells
  • Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus
  • Cutaneous Microvascular Dysfunction Is Associated With Human Leukocyte Antigen-DQ in Youths With Type 1 Diabetes.
  • Functional C1-inhibitor diagnostics in hereditary angioedema: Assay evaluation and recommendations
  • Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus
  • Impaired opsonisation with C3b and phagocytosis of Streptococcus pneumoniae in serum from subjects with defects in the classical complement pathway.
  • Impaired opsonization with C3b and phagocytosis of Streptococcus pneumoniae in sera from subjects with defects in the classical complement pathway
  • Role of C1q in regulation of IFN-alpha production
  • SLE serum induces classical caspase-dependent apoptosis independent of death receptors
  • Serum bactericidal activity against Neisseria meningitidis in patients with C3 nephritic factors is dependent on IgG allotypes.
• 2007
  • A genetic basis of susceptibility to acute pyelonephritis.
  • A polymorphic variant in the MHC2TA gene is not associated with systemic lupus erythematosus
  • Allergiska och immunologiska tillstånd.
  • Association between SLE nephritis and polymorphic variants of the CRP and Fc gamma RIIIa genes
  • Association between SLE nephritis and polymorphic variants of the CRP and Fc{gamma}RIIIa genes.
  • Association of a CD24 gene polymorphism with susceptibility to systemic lupus erythematosus
  • Association of a CD24 gene polymorphism with susceptiblity to SLE
  • Complement analysis in the 21st century
  • Complement deficiencies and systemic lupus erythematosus
  • Design of recombinant antibody microarrays for serum protein profiling: Targeting of complement proteins
  • Gene-environment interactions in the aetiology of systemic lupus erythematosus
  • Gene-environment interactions in the aetiology of systemic lupus erythematosus.
  • Genetically determined mannan-binding lectin deficiency is of minor importance in determining susceptibility to severe infections and vascular organ damage in systemic lupus erythematosus.
  • Residual adverse changes in arterial endothelial function and LDL oxidation after a mild systemic inflammation induced by influenza vaccination
  • Rheumatological manifestations, organ damage and autoimmunity in hereditary C2 deficiency.
  • The impact of IL-1Ra and MBL gene polymorphisms on joint damage after 5 and 10 years in patients with early rheumatoid arthritis
• 2006
  • Antibodies against Four Proteins from a Streptococcus pyogenes Serotype M1 Strain and Levels of Circulating Mannan-Binding Lectin in Acute Poststreptococcal Glomerulonephritis.
  • Association of HLA-C3 and smoking with vasculitis in patients with rheumatoid arthritis.
  • Complement deficiency and disease: An update.
  • Complement deficiency and disease: un update
  • Homozygosity for the IgG2 subclass allotype G2M(n) protects against severe infection in hereditary C2 deficiency
  • Influence of methotrexate, TNF blockers and prednisolone on antibody responses to pneumococcal polysaccharide vaccine in patients with rheumatoid arthritis.
  • Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2.
  • Predictors of infusion reactions during infliximab treatment in patients with arthritis.
  • Properdin deficiency in a boy with fulminant meningococcal septic shock
  • Systemic white blood and endothelial cell response after revascularization of critical limb ischemia is only influenced in case of ischemic ulcers.
• 2005
  • Complement and its breakdown products in SLE.
  • Complement factor I deficiency associated with recurrent infections, vasculitis and immune complex glomerulonephritis
  • Critical role for complement receptor 3 (CD11b/CD18), but not for Fc receptors, in killing of Streptococcus pyogenes by neutrophils in human immune serum.
  • Deficiency of the mannan-binding lectin pathway of complement and poor outcome in cystic fibrosis: bacterial colonization may be decisive for a relationship.
  • Hereditary C2 Deficiency in Sweden: Frequent Occurrence of Invasive Infection, Atherosclerosis, and Rheumatic Disease.
  • Inflammatory markers and IL-6 polymorphism in peripheral arterial disease with and without diabetes mellitus.
  • The impact of HLA-DRB1 genes on extra-articular disease manifestations in rheumatoid arthritis.
• 2004
  • Analysis of HLA DR, HLA DQ, C4A, FcgammaRIIa, FcgammaRIIIa, MBL, and IL-1Ra allelic variants in Caucasian systemic lupus erythematosus patients suggests an effect of the combined FcgammaRIIa R/R and IL-1Ra 2/2 genotypes on disease susceptibility.
  • Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond
  • Induction of apoptosis in monocytes and lymphocytes by serum from patients with systemic lupus erythematosus - an additional mechanism to increased autoantigen load?
  • Intraperitoneal cytokine response after major surgery: higher postoperative intraperitoneal versus systemic cytokine levels suggest the gastrointestinal tract as the major source of the postoperative inflammatory reaction
  • Polymorphisms of the Fc gamma receptor type IIB gene are not associated with systemic lupus erythematosus in the Swedish population
  • Postoperative on-line monitoring with intraperitoneal microdialysis is a sensitive clinical method for measuring increased anaerobic metabolism that correlates to the cytokine response
  • Transcriptional down-regulation of the platelet ADP receptor P2Y(12) and clusterin in patients with systemic lupus erythematosus.
  • White blood cell and endothelial cell response to endovascular procedures in the leg.
• 2003
  • Cystic fibrosis patients heterozygous for MASP-2 gene mutation have lowered MASP-2 concentration, without relation to clinical findings
  • Flavonoid treatment in patients with healed venous ulcer: flow cytometry analysis suggests increased CD11b expression on neutrophil granulocytes in the circulation
  • Immunoglobulin deficiencies and susceptibility to infection among homozygotes and heterozygotes for C2 deficiency
  • Serologisk diagnostik vid autoimmuna sjukdomar.
  • The heterogeneity of neuropsychiatric systemic lupus erythematosus is reflected in lack of association with cerebrospinal fluid cytokine profiles.
  • Total C4B deficiency due to gene deletion and gene conversion in a patient with severe infections
• 2002
  • A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans
  • Contact-system activation in children with vasculitis.
  • Early treatment with lexipafant, a platelet-activating factor-receptor antagonist, is not sufficient to prevent pulmonary endothelial damage after intestinal ischaemia and reperfusion in rats.
• 2001
  • Increased endothelial expression of HLA-DQ and interleukin 1alpha in extra-articular rheumatoid arthritis. Results from immunohistochemical studies of skeletal muscle
  • Increased level of soluble HLA class I antigens in systemic lupus erythematosus: correlation with anti-DNA antibodies and leukopenia
  • Increased levels of soluble HLA class I antigens in SLE: correlation with anti-DNA antibodies and with leukopenia
• 2000
  • Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies
  • Binding of immune complexes to erythrocyte CR1 (CD35): difference in requirement of classical pathway components and indication of alternative pathway-mediated binding in C2-deficiency
• 1999
  • A comparison of genome-scans performed in multicase families with systemic lupus erythematosus from different population groups
  • Synergetic effect between interleukin-1 receptor antagonist allele (IL1RN*2) and MHC class II (DR17,DQ2) in determining susceptibility to systemic lupus erythematosus
• 1998
  • Characterization of non-expressed C4 genes in a case of complete C4 deficiency: identification of a novel point mutation leading to a premature stop codon
  • Expression of properdin in complete and incomplete deficiency: normal in vitro synthesis by monocytes in two cases with properdin deficiency type II due to distinct mutations
• 1995
  • Serum concentrations of C4 isotypes and factor B in type I C2 deficiency suggest haplotype-dependent quantitative expression of MHC class III complement genes
  • Sharing of MHC haplotypes among patients with systemic lupus erythematosus from unrelated Caucasian multicase families: disease association with the extended haplotype HLA-B8, SC01, DR17
• 1993
  • Antiproliferative effects on human peripheral blood mononuclear cells and inhibition of in vitro immunoglobulin synthesis by Podophyllotoxin (CPH86) and by semisynthetic lignan glycosides (CPH82)
• 1987
  • Hyaluronidase treatment of synovial fluid affects the recovery of mononuclear cells and their in vitro immunoglobulin synthesis