Sven Påhlman
Titel
Professor
Organisation
+4640337403
Sven [dot] Pahlman [at] med [dot] lu [dot] se
Publikationer (hämtat ur Lunds universitets publikationsdatabas)
författare
- 2013
- 2012
- Cancer cell differentiation heterogeneity and aggressive behavior in solid tumors.
- HIF-2α Expression Is Suppressed in SCLC Cells, Which Survive in Moderate and Severe Hypoxia When HIF-1α Is Repressed.
- Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells.
- Neuroblastoma: Role of hypoxia and hypoxia inducible factors in tumor progression
- Tumor-initiating cells in childhood neuroblastoma--letter.
- 2011
- High nuclear RBM3 expression is associated with an improved prognosis in colorectal cancer
- Hunting for Protein Markers of Hypoxia by Combining Plasma Membrane Enrichment with a New Approach to Membrane Protein Analysis
- JAG2 induction in hypoxic tumor cells alters Notch signaling and enhances endothelial cell tube formation.
- Neuroblastoma aggressiveness in relation to sympathetic neuronal differentiation stage.
- Neuroblastoma research progress - A 2011 perspective
- Prognostic Value of SOX2 Expression in Neuroblastoma
- 2010
- 2009
- Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells.
- Effects of hypoxia on small cell lung carcinoma cells
- Erythropoietin Receptor Expression and Correlation to Tamoxifen Response and Prognosis in Breast Cancer.
- HIF-1alpha induces MXI1 by alternate promoter usage in human neuroblastoma cells.
- HIF-1{alpha} and HIF-2{alpha} Are Differentially Regulated In vivo in Neuroblastoma: High HIF-1{alpha} Correlates Negatively to Advanced Clinical Stage and Tumor Vascularization.
- HIF-2 alpha maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells
- Nuclear expression of the RNA-binding protein RBM3 is associated with an improved clinical outcome in breast cancer.
- 2008
- Binomial mitotic segregation of MYCN-carrying double minutes in neuroblastoma illustrates the role of randomness in oncogene amplification.
- Differentiation induced by physiological and pharmacological stimuli leads to increased antigenicity of human neuroblastoma cells
- High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma.
- High levels of HIF-2alpha highlight an immature neural crest-like neuroblastoma cell cohort located in a perivascular niche.
- Hypoxia-inducible factor-2alpha correlates to distant recurrence and poor outcome in invasive breast cancer.
- Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase.
- Stem cell factor induces HIF-1alpha at normoxia in hematopoietic cells.
- Transcriptional adaptation of neuroblastoma cells to hypoxia.
- 2007
- Arsenic trioxide and neuroblastoma cytotoxicity.
- Arsenic trioxide-induced neuroblastoma cell death is accompanied by proteolytic activation of nuclear Bax.
- Combined IFN-gamma and retinoic acid treatment targets the N-Myc/Max/Mad1 network resulting in repression of N-Myc target genes in MYCN-amplified neuroblastoma cells
- From critters to cancers: bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia
- Hypoxia inducible factor-2alpha in cancer.
- Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands.
- Neuroblastoma as an experimental model for neuronal differentiation and hypoxia-induced tumor cell dedifferentiation.
- 2006
- Effect of hypoxia on the tumor phenotype: the neuroblastoma and breast cancer models
- Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes
- Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype.
- Translocation-excision-deletion-amplification mechanism leading to nonsyntenic coamplification of MYC and ATBF1
- 2005
- ERK1/2 inhibition increases antiestrogen treatment efficacy by interfering with hypoxia-induced downregulation of ERalpha: a combination therapy potentially targeting hypoxic and dormant tumor cells.
- HIF-2alpha expression in human fetal paraganglia and neuroblastoma: relation to sympathetic differentiation, glucose deficiency, and hypoxia.
- Hypoxia-induced dedifferentiation of tumor cells - A mechanism behind heterogeneity and aggressiveness of solid tumors.
- Multidrug-resistant neuroblastoma cells are responsive to arsenic trioxide at both normoxia and hypoxia.
- Phenotypic persistence after reoxygenation of hypoxic neuroblastoma cells.
- Positional and functional mapping of a neuroblastoma differentiation gene on chromosome 11
- 2004
- Arsenic trioxide-induced death of neuroblastoma cells involves activation of Bax and does not require p53.
- Erythropoietin enhances response to treatment in patients with advanced breast cancer
- Human neuroblastoma cells exposed to hypoxia: induction of genes associated with growth, survival, and aggressive behavior.
- Induction of ID2 expression by hypoxia-inducible factor-1: ARole in dedifferentiation of hypoxic neuroblastoma cells.
- Neuroblastoma cells with overexpressed MYCN retain their capacity to undergo neuronal differentiation.
- Notch signaling in neuroblastoma.
- Ubiquilin-1 is a novel HASH-1-complexing protein that regulates levels of neuronal bHLH transcription factors in human neuroblastoma cells.
- 2003
- Expression of trkB in Human Neuroblastoma in Relation to MYCN Expression and Retinoic Acid Treatment.
- Hypoxia promotes a dedifferentiated phenotype in ductal breast carcinoma in situ.
- Hypoxia-induced dedifferentiation in neuroblastoma cells.
- ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value
- Regional cyclin D1 overexpression or hypoxia correlate inversely with heterogeneous oestrogen receptor-alpha expression in human breast cancer.
- 2002
- Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype.
- Modulation of Basic Helix-Loop-Helix Transcription Complex Formation by Id Proteins during Neuronal Differentiation.
- Protein Kinase Cepsilon Actin-binding Site Is Important for Neurite Outgrowth during Neuronal Differentiation.
- 2001
- 2000
- 1999
- Human achaete-scute homologue 1 (HASH-1) is downregulated in differentiating neuroblastoma cells
- Novel and classical protein kinase C isoforms have different functions in proliferation, survival and differentiation of neuroblastoma cells
- PKCepsilon, via its regulatory domain and independently of its catalytic domain, induces neurite-like processes in neuroblastoma cells
- The basic helix-loop-helix transcription factor dHAND, a marker gene for the developing human sympathetic nervous system, is expressed in both high- and low-stage neuroblastomas
