Leif Groop
Titel
Professor/forskargruppschef
Organisation
+4640391202
+46705912548
Leif [dot] Groop [at] med [dot] lu [dot] se
Publikationer (hämtat ur Lunds universitets publikationsdatabas)
författare
- 2013
- A link between GIP and osteopontin in adipose tissue and insulin resistance.
- Alterations in bile acid synthesis in carriers of HNF1α mutations.
- Effect of Common Genetic Variants Associated with Type 2 Diabetes and Glycemic Traits on α- and β-cell Function and Insulin Action in Man.
- Effects of ingestion routes on hormonal and metabolic profiles in gastric-bypassed humans
- Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
- Genetics of diabetes - Are we missing the genes or the disease?
- Insights Into the Molecular Mechanism for Type 2 Diabetes Susceptibility at the KCNQ1 Locus From Temporal Changes in Imprinting Status in Human Islets
- Large-scale association analysis identifies new risk loci for coronary artery disease
- 2012
- A Single Nucleotide Polymorphism Associates With the Response of Muscle ATP Synthesis to Long-Term Exercise Training in Relatives of Type 2 Diabetic Humans
- A common variant upstream of the PAX6 gene influences islet function in man.
- A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
- A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.
- Analysis of case-control association studies with known risk variants
- Association between depressive symptoms and metabolic syndrome is not explained by antidepressant medication: Results from the PPP-Botnia Study
- Association of variants in HLA-DQA1-DQB1, PTPN22, INS, and CTLA4 with GAD autoantibodies and insulin secretion in nondiabetic adults of the Botnia Prospective Study
- Codon 72 polymorphism (rs1042522) of TP53 is associated with changes in diastolic blood pressure over time
- Common variant in the HMGA2 gene increases susceptibility to nephropathy in patients with type 2 diabetes.
- Differential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance.
- Effect of a common variant of the PCSK2 gene on reduced insulin secretion.
- FTO genotype is associated with phenotypic variability of body mass index
- First-Degree Relatives of Type 2 Diabetic Patients Have Reduced Expression of Genes Involved in Fatty Acid Metabolism in Skeletal Muscle.
- Genetic Variation in the Glucose-Dependent Insulinotropic Polypeptide Receptor Modifies the Association between Carbohydrate and Fat Intake and Risk of Type 2 Diabetes in the Malmo Diet and Cancer Cohort.
- Genetic prediction of postpartum diabetes in women with gestational diabetes mellitus
- Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes.
- Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies
- Intraorbital deiodinase type 2 expression is downregulated in chronic phase of Graves' ophthalmopathy.
- Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
- Metabolite Profiling Reveals Normal Metabolic Control in Carriers of Mutations in the Glucokinase Gene (MODY2).
- New Susceptibility Loci Associated with Kidney Disease in Type 1 Diabetes
- No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels
- Physical activity reduces the risk of incident type 2 diabetes in general and in abdominally lean and obese men and women: the EPIC-InterAct Study
- Reduced Insulin Exocytosis in Human Pancreatic β-cells With Gene Variants Linked to Type 2 Diabetes.
- Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes.
- Regulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes - A role for the transcription factor NFAT and phosphodiesterase 3B.
- SNP in the genome-wide association study hotspot on chromosome 9p21 confers susceptibility to diabetic nephropathy in type 1 diabetes
- Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.
- Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases
- Subjective Sleep Complaints Are Associated With Insulin Resistance in Individuals Without Diabetes The PPP-Botnia Study
- Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway.
- Telomere length in blood and skeletal muscle in relation to measures of glycaemia and insulinaemia.
- The Triglyceride Content in Skeletal Muscle Is Associated with Hepatic But Not Peripheral Insulin Resistance in Elderly Twins.
- Validation of a multi-marker model for the prediction of incident type 2 diabetes mellitus: Combined results of the Inter99 and Botnia studies.
- Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents
- Worse glycaemic control in LADA patients than in those with type 2 diabetes, despite a longer time on insulin therapy.
- Zinc Transporter 8 Autoantibodies and Their Association With SLC30A8 and HLA-DQ Genes Differ Between Immigrant and Swedish Patients With Newly Diagnosed Type 1 Diabetes in the Better Diabetes Diagnosis Study.
- γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes.
- 2011
- A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes.
- A common variant near the PRL gene is associated with increased adiposity in males
- A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes
- Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies
- Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes.
- Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction
- Depressive Symptoms, Antidepressant Medication Use, and Insulin Resistance The PPP-Botnia Study
- Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study
- Exercise capacity in relation to body fat distribution and muscle fibre distribution in elderly male subjects with impaired glucose tolerance, type 2 diabetes and matched controls.
- FTO, Type 2 Diabetes, and Weight Gain Throughout Adult Life A Meta-Analysis of 41,504 Subjects From the Scandinavian HUNT, MDC, and MPP Studies
- Gene Expression in Graves' Ophthalmopathy and Arm Lymphedema: Similarities and Differences.
- Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
- Genetics of Type 2 Diabetes.
- Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes
- Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
- Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study.
- High prevalence of type 2 diabetes in Iraqi and Swedish residents in a deprived Swedish neighbourhood - a population based study
- Insulin Reduces Neuronal Excitability by Turning on GABA(A) Channels that Generate Tonic Current
- Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets.
- LifeGene-a large prospective population-based study of global relevance
- Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children
- Pleiotropic Effects of GIP on Islet Function Involve Osteopontin
- Power in the Phenotypic Extremes: A Simulation Study of Power in Discovery and Replication of Rare Variants
- Relation between cycling exercise capacity, fiber-type composition, and lower extremity muscle strength and muscle endurance.
- The Genetic Structure of the Swedish Population
- The expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes.
- Two common genetic variants near nuclear encoded OXPHOS genes are associated with insulin secretion in vivo.
- Two-Step Approach for the Prediction of Future Type 2 Diabetes Risk
- Upper Body Muscle Strength and Endurance in Relation to Peak Exercise Capacity During Cycling in Healthy Sedentary Male Subjects.
- Uromodulin gene variant is associated with type 2 diabetic nephropathy.
- 2010
- A common variant in the PAX6 gene influences islet function in man
- A family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia study
- A mRNA marker for glycolytic muscle fibres may be used to determine fibre type composition in human skeletal muscle
- An empirical index of insulin sensitivity from short IVGTT: validation against the minimal model and glucose clamp indices in patients with different clinical characteristics
- An investigation of serum concentration of apoM as a potential MODY3 marker using a novel ELISA.
- Analysis of TBC1D4 in patients with severe insulin resistance
- Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- Biological, clinical and population relevance of 95 loci for blood lipids
- Brain natriuretic peptide is related to diastolic dysfunction whereas urinary albumin excretion rate is related to left ventricular mass in asymptomatic type 2 diabetes patients
- Common Inherited Variation in Mitochondrial Genes Is Not Enriched for Associations with Type 2 Diabetes or Related Glycemic Traits
- Deoxyribonucleic Acid Methylation and Gene Expression of PPARGC1A in Human Muscle Is Influenced by High-Fat Overfeeding in a Birth-Weight-Dependent Manner.
- Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans
- Differences in associations between HSD11B1 gene expression and metabolic parameters in subjects with and without impaired glucose homeostasis
- Effect of variants in the RORA gene on risk of type 2 diabetes
- Erratum to: Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 finnish adults.
- Evidence that BMI and type 2 diabetes share only a minor fraction of genetic variance: a follow-up study of 23,585 monozygotic and dizygotic twins from the Finnish Twin Cohort Study
- GAD Antibody Positivity Predicts Type 2 Diabetes in an Adult Population
- Genetic association analysis of LARS2 with type 2 diabetes
- Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes
- Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
- Genetics of type 2 diabetes -Are we getting any closer?
- Genome wide association analysis for free fatty acid levels in DGI
- Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution
- Genome-wide meta-analyses identify multiple loci associated with smoking behavior
- Hundreds of variants clustered in genomic loci and biological pathways affect human height
- Impact of exercise intensity and duration on insulin sensitivity in women with T2D.
- Individualizing Therapies in Type 2 Diabetes Mellitus Based on Patient Characteristics: What We Know and What We Need to Know.
- Influence of novel genetic loci affecting glucose and insulin levels during OGTT on islet function in man
- Investigation of Type 2 Diabetes Risk Alleles Support CDKN2A/B, CDKAL1, and TCF7L2 As Susceptibility Genes in a Han Chinese Cohort
- Latent Autoimmune Diabetes in Adults Differs Genetically From Classical Type 1 Diabetes Diagnosed After the Age of 35 Years
- Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
- Minimal Contribution of Fasting Hyperglycemia to the Incidence of Type 2 Diabetes in Subjects With Normal 2-h Plasma Glucose
- New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
- NordicDB: a Nordic pool and portal for genome-wide control data
- Open chromatin and diabetes risk.
- Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes.
- Plasma copeptin and the risk of diabetes mellitus.
- Prediction of postpartum diabetes in women with gestational diabetes mellitus
- Resistance to exercise-induced changes in the global DNA methylation pattern of skeletal muscle in individuals with a family history of type 2 diabetes
- Risk genotypes, allele-specific expression and methylation status in human islets at the KCNQ1 type 2 diabetes-susceptibility locus
- Stressful Life Events and the Metabolic Syndrome - The Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia Study
- TCF7L2-conferred apoptosis in pancreatic beta cells involves the p53 pathway
- The Association of Mitochondrial Content with Prevalent and Incident Type 2 Diabetes.
- The shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes
- Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
- 2009
- A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals.
- A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans
- A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion.
- Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults.
- Calpain-10 expression is elevated in pancreatic islets from patients with type 2 diabetes.
- Clinical Risk Factors, DNA Variants, and the Development of Type 2 Diabetes THE AUTHORS REPLY
- Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.
- Common variants at 30 loci contribute to polygenic dyslipidemia
- Control of ACAT2 Liver Expression by HNF4{alpha}. Lesson From MODY1 Patients.
- Disruption of TFB1M impairs insulin secretion in beta cells
- Effect of pioglitazone versus insulin glargine on cardiac size, function, and measures of fluid retention in patients with type 2 diabetes
- Effects of six months of moderate resistance-versus endurance-training on muscle ATP synthesis in first-degree relatives of patients with type 2 diabetes
- Epigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes
- Evaluation of chloride channel-3 as a potential target for TCF7L2-dependent impairment of insulin secretion
- Evaluation of the effects of exercise on insulin sensitivity in Arabian and Swedish women with type 2 diabetes.
- Fasting Versus Postload Plasma Glucose Concentration and the Risk for Future Type 2 Diabetes Results from the Botnia Study
- Functional Variant Disrupts Insulin Induction of USF1 Mechanism for USF1-Associated Dyslipidemias
- Genetic basis of beta-cell dysfunction in man.
- Genetic dissection of type 2 diabetes.
- Genetic variation in ATP5O is associated with skeletal muscle ATP50 mRNA expression and glucose uptake in young twins.
- Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs
- Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts
- Genetics of type 2 diabetes. An overview.
- Genetics of type 2 diabetes. On overview.
- Genome-wide association study for type 2 diabetes: clinical applications.
- Genome-wide association study identifies eight loci associated with blood pressure
- Hyperactivity in adrenergic signalling via alpha2A receptors contributes to human type 2 diabetes
- Impaired Mitochondrial Function and Insulin Resistance of Skeletal Muscle in Mitochondrial Diabetes
- Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes
- Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant-174GC with circulating glucose levels, interleukin-6 levels, and body mass index
- Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene.
- Novel Genetic Loci Implicated in Fasting Glucose Homeostasis and Their Impact on Related Metabolic Traits
- Prediction of Non-Alcoholic Fatty Liver Disease and Liver Fat Using Metabolic and Genetic Factors
- Previously Associated Type 2 Diabetes Variants May Interact With Physical Activity to Modify the Risk of Impaired Glucose Regulation and Type 2 Diabetes A Study of 16,003 Swedish Adults
- Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus
- Regulation and Function of FTO mRNA Expression in Human Skeletal Muscle and Subcutaneous Adipose Tissue
- Short-Term Exercise Training Does Not Stimulate Skeletal Muscle ATP Synthesis in Relatives of Humans With Type 2 Diabetes
- Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
- The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men
- The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects
- The diabetes risk score outperforms fasting plasma glucose and glucose tolerance tests: combined results from the Inter99 and Botnia Studies
- The impact of differential splicing of TCF7L2 on target gene expression in human islet of Langerhans
- Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion.
- Tissue-specific alternative splicing of TCF7L2
- Underlying Genetic Models of Inheritance in Established Type 2 Diabetes Associations
- Unique splicing pattern of the TCF7L2 gene in human pancreatic islets.
- Variants in MTNR1B influence fasting glucose levels
- 2008
- A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population
- Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle.
- Assessment of exercise capacity in women with type 2 diabetes.
- Association between LTA, TNF and AGER polymorphisms and late diabetic complications.
- C/EBP{alpha} in adipose tissue regulates genes in lipid and glucose metabolism and a genetic variation in C/EBP{alpha} is associated with serum levels of triglycerides.
- Can complement factors 5 and 8 and transthyretin be used as biomarkers for MODY 1 (HNF4A-MODY) and MODY 3 (HNF1A-MODY)?
- Clinical risk factors, DNA variants, and the development of type 2 diabetes.
- Common variants in MODY genes and future risk of type 2 diabetes.
- Common variants in or around the JAZF1, CDKN2A/2B, CDKAL1 and WFS1 genes discriminate between autoimmune and non-autoimmune diabetes
- Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15-34 years) but not in middle-aged (40-59 years) diabetic patients.
- Common variants near MC4R are associated with fat mass, weight and risk of obesity
- Differences in effects of insulin glargine or pioglitazone added to oral anti-diabetic therapy in patients with type 2 diabetes What to add-Insulin glargine or pioglitazone?
- Discerning the ancestry of European Americans in genetic association studies
- Effect of exercise on gene transcript profiles in skeletal muscle of individuals with and without a family history of diabetes
- Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion.
- Expression of the transcription factor 7-like 2 gene (TCF7L2) in human adipocytes is down regulated by insulin.
- GENETIC SIMILARITIES BETWEEN LADA, TYPE 1 AND TYPE 2 DIABETES.
- Genes and type 2 diabetes mellitus.
- Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study)
- Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes
- Genetic variation in ATP5O is associated with mRNA expression in human skeletal muscle and in vivo glucose uptake
- Identification of ten loci associated with height highlights new biological pathways in human growth
- Immigrants from the Middle-East have a different form of Type 2 diabetes compared with Swedish patients.
- Independent introduction of two lactase-persistence alleles into human populations reflects different history of adaptation to milk culture
- Independent measures of insulin secretion and insulin sensitivity during the same test: the glucagon-insulin tolerance test.
- Interactions between genes and birth size for development of type 2 diabetes
- Is there a unifying genetic factor predisposing to the metabolic syndrome?
- Large-scale association study between two coding LRP5 gene polymorphisms and bone phenotypes and fractures in men
- Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
- Metabolic effects of novel type 2 diabetes genes in a population aged 18-75 years
- New insights into impaired muscle glycogen synthesis.
- PGC-1 alpha and PGC-1 beta are related to markers for fibre type composition in human skeletal muscle
- Polymorphism associated with cholesterol and risk of cardiovascular events
- Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
- Strategies for Conditional Two-Locus Nonparametric Linkage Analysis.
- The Pro12Ala polymorphism of the PPAR-gamma2 gene affects associations of fish intake and marine n-3 fatty acids with glucose metabolism
- The search for putative unifying genetic factors for components of the metabolic syndrome.
- Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
- Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.
- 2007
- A common variant of HMGA2 is associated with adult and childhood height in the general population
- A variant in the transcription factor 7-like 2 (TCF7L2) gene is associated with an increased risk of gestational diabetes mellitus.
- Associating mitochondrial DNA variation with complex traits - Reply to Elson et al.
- Association of microsatellite polymorphisms of the human 14q13.2 region with type 2 diabetes mellitus in latvian and finnish populations
- Association studies of BMI and type 2 diabetes in the neuropeptide y pathway - A possible role for NPY2R as a candidate gene for type 2 diabetes in men
- Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes
- COX-2 and SCD, markers of inflammation and adipogenesis, are related to disease activity in Graves' ophthalmopathy
- Evidence of still-ongoing convergence evolution of the lactase persistence T-13910 alleles in humans
- From fused toes in mice to human obesity
- From fused toes in mice to human obesity.
- Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle
- Genetics of gestational diabetes mellitus.
- Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
- Impact of the peroxisome proliferator activated receptor-gamma coactivator-1 beta (PGC-1 beta) Ala203Pro polymorphism on in vivo metabolism, PGC-1 beta expression and fibre type composition in human skeletal muscle
- In Process Citation
- Interaction between the angiotensin-converting enzyme gene insertion/deletion polymorphism and obstructive sleep apnoea as a mechanism for hypertension.
- MODY--en autosomalt dominant form av diabetes. Diagnos via gentestning ger bättre behandling
- Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.
- Polymorphisms in the gene encoding the voltage-dependent Ca(2+) channel Ca (V)2.3 (CACNA1E) are associated with type 2 diabetes and impaired insulin secretion
- Regulation of skeletal muscle PPAR delta mRNA expression in twins
- Relationships of plasma adiponectin level and adiponectin receptors 1 and 2 gene expression to insulin sensitivity and glucose and fat metabolism in monozygotic and dizygotic twins.
- TXNIP regulates peripheral glucose metabolism in humans
- The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts
- The intake of potatoes and glucose metabolism in subjects at high risk for Type 2 diabetes
- Thyrostimulin (a TSH-like Hormone) Expression in Orbital and Thyroid Tissue.
- Tyypin 2 diabeteksen genetiikka selviamassa. Taustalla monen heikkotehoisen alttiusgeenin yhteispeli
- Variants in the FFAR1 Gene Are Associated with Beta Cell Function
- Variation in GYS1 Interacts with Exercise and Gender to Predict Cardiovascular Mortality.
- Yksi, kaksi vai monta diabetesta?
- 2006
- A dietary exchange of common bread for tailored bread of low glycaemic index and rich in dietary fibre improved insulin economy in young women with impaired glucose tolerance.
- A polymorphism in the adiponectin gene influences adiponectin expression levels in visceral fat in obese subjects
- Analysis of the interleukin-1 and interleukin-6 polymorphisms in patients with chronic periodontitis. A pilot study
- Association of the calpain-10 gene with type 2 diabetes in Europeans: Results of pooled and meta-analyses
- Authors' reply.
- Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals
- Common variants in HNF-1 alpha and risk of type 2 diabetes.
- Common variants in MODY genes increase the risk of gestational diabetes mellitus.
- Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity
- Complex Relationship Between Blood Pressure and Mortality in Type 2 Diabetic Patients. A Follow-Up of the Botnia Study.
- Comprehensive association testing of common mitochondrial DNA variation in metabolic disease
- Genetic and nongenetic determinants of skeletal muscle glucose transporter 4 messenger ribonucleic acid levels and insulin action in twins
- Glycaemic and nonglycaemic effects of pioglitazone in triple oral therapy of patients with type 2 diabetes.
- Glycemic and non-glycemic effects of pioglitazone in triple oral therapy in patients with type 2 diabetes mellitus
- HLA-DQB1 genotypes, islet antibodies and beta cell function in the classification of recent-onset diabetes among young adults in the nationwide Diabetes Incidence Study in Sweden.
- High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people
- IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies
- Improved prandial glucose control with lower risk of hypoglycemia with nateglinide than with glibenclamide in patients with maturity-onset diabetes of the young type 3
- Latent autoimmune diabetes in adults (LADA)-more than a name.
- Long-term beneficial effects of glipizide treatment on glucose tolerance in subjects with impaired glucose tolerance
- Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality.
- The -374 T/A polymorphism in the gene encoding RAGE is associated with diabetic nephropathy and retinopathy in type 1 diabetic patients.
- The Kruppel-like factor 11 (KLF11) Q62R polymorphism is not associated with type 2 diabetes in 8,676 people
- The hormone-sensitive lipase C-60G promoter polymorphism is associated with increased waist circumference in normal-weight subjects.
- Transferability of tag SNPs in genetic association studies in multiple populations
- Treatment with a thiazolidinedione increases eye protrusion in a subgroup of patients with type 2 diabetes.
- Type 2 diabetes and risk for periodontal disease: a role for dental health awareness
- Variation in the adiponutrin gene influences its expression and associates with obesity.
- 2005
- A male-specific quantitative trait locus on 1p21 controlling human stature
- Association of common variation in the HNF1 alpha gene region with risk of type 2 diabetes
- Association of the E23K polymorphism in the KCNJ11 gene with gestational diabetes mellitus.
- Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people
- Association testing of variants in the hepatocyte nuclear factor 4 alpha gene with risk of type 2 diabetes in 7,883 people
- Calpain 10 and type 2 diabetes: are we getting closer to an explanation?
- Demonstrating stratification in a European American population
- Dipping and variability of blood pressure and heart rate at night are heritable traits.
- Genetic and Nongenetic Regulation of CAPN10 mRNA Expression in Skeletal Muscle.
- Genetic and non-genetic determinants of skeletal muscle GLUT4 mRNA levels and insulin action in twins.
- Genetic prediction of future type 2 diabetes
- Genetic testing for maturity onset diabetes of the young: uptake, attitudes and comparison with hereditary non-polyposis colorectal cancer
- Haplotype construction of the FRDA gene and evaluation of its role in type II diabetes.
- Heritability of model-derived parameters of beta cell secretion during intravenous and oral glucose tolerance tests: a study of twins
- Insulin sensitivity in adults with growth hormone deficiency and effect of growth hormone treatment.
- Nt-proANP in plasma, a marker of salt sensitivity, is reduced in type 2 diabetes patients.
- Overexpression of immediate early genes in active Graves' ophthalmopathy.
- Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes.
- Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men
- Role of the FOXC2 -512C>T polymorphism in type 2 diabetes: possible association with the dysmetabolic syndrome.
- 2004
- Association between a polymorphism in the carboxyl ester lipase gene and serum cholesterol profile
- Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes
- Candidate genes for type 2 diabetes.
- Characterization of the human skeletal muscle glycogen synthase gene (GYS1) promoter.
- Contribution of insulin-stimulated glucose uptake and basal hepatic insulin sensitivity to surrogate measures of insulin sensitivity.
- Cosegregation of MIDD and MODY in a Pedigree: Functional and Clinical Consequences.
- Effects of morning cortisol replacement on glucose and lipid metabolism in GH-treated subjects.
- Elevated Plasma Levels of Nt-proBNP in Patients With Type 2 Diabetes Without Overt Cardiovascular Disease.
- Genotypic and phenotypic differences between Arabian and Scandinavian women with gestational diabetes mellitus.
- Haplotype Structure and Genotype-Phenotype Correlations of the Sulfonylurea Receptor and the Islet ATP-Sensitive Potassium Channel Gene Region.
- Heritability of ambulatory and office blood pressure phenotypes in Swedish families.
- Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins.
- Parallel manifestation of insulin resistance and beta cell decompensation is compatible with a common defect in Type 2 diabetes.
- Putative role of polymorphisms in UCP1-3 genes for diabetic nephropathy.
- Statistical concerns about the GSEA procedure - Reply
- The FOXC2 C-512T Polymorphism Is Associated with Obesity and Dyslipidemia.
- Variation in the calpain-10 gene is associated with elevated triglyceride levels and reduced adipose tissue messenger ribonucleic acid expression in obese Swedish subjects.
- 2003
- A Combination of Human Leukocyte Antigen DQB1*02 and the Tumor Necrosis Factor alpha Promoter G308A Polymorphism Predisposes to an Insulin-Deficient Phenotype in Patients with Type 2 Diabetes.
- A Genome-Wide Scan in Families With Maturity-Onset Diabetes of the Young: Evidence for Further Genetic Heterogeneity.
- A genome wide scan for early onset primary hypertension in Scandinavians.
- A meta-analysis of four European genome screens (GIFT Consortium) shows evidence for a novel region on chromosome 17p11.2-q22 linked to type 2 diabetes.
- Associations of dietary fiber with glucose metabolism in nondiabetic relatives of subjects with type 2 diabetes - The Botnia Dietary Study
- Bringing diabetes therapeutics to the big screen.
- Development of New Peripheral Arterial Occlusive Disease in Patients With Type 2 Diabetes During a Mean Follow-Up of 11 Years.
- Dietary intakes and plasma concentrations of carotenoid's and tocopherols in relation to glucose metabolism in subjects at high risk of type 2 diabetes: the Botnia Dietary Study
- Familiality of metabolic abnormalities is dependent upon age at onset and phenotype of the type 2 diabetic proband.
- Fat feeding impairs glycogen synthase activity in mice without effects on its gene expression.
- Growth hormone replacement therapy induces insulin resistance by activating the glucose-Fatty Acid cycle.
- Impaired cathepsin L gene expression in skeletal muscle is associated with type 2 diabetes.
- Importance of obtaining independent measures of insulin secretion and insulin sensitivity during the same test - Results with the Botnia clamp
- Influence of glucose and insulin on transcapillary fluid absorption from the arm during lower body negative pressure in man
- Inhibition of lipolysis during acute GH exposure increases insulin sensitivity in previously untreated GH-deficient adults.
- Intrauterine hyperglycemia modifying the development of (monogenic) diabetes?
- No evidence of a relation between 11beta-hydroxysteroid dehydrogenasetype 2 activity and salt sensitivity.
- PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.
- Peroxisome proliferator-activated receptor-gammaPro12Ala polymorphism and the association with blood pressure in type 2 diabetes: Skaraborg Hypertension and Diabetes Project.
- Polymorphisms of the HDL receptor gene associated with HDL cholesterol levels in diabetic kindred from three populations
- The SLC6A14 gene shows evidence of association with obesity
- The insertion/deletion variation in the alpha2B-adrenoceptor does not seem to modify the risk for acute myocardial infarction, but may modify the risk for hypertension in sib-pairs from families with type 2 diabetes
- Three weeks dietary intervention with low-glycaemic index bread improved insulin economy in women with high risk of type II diabetes
- 2002
- 5 ' flanking variants of resistin are associated with obesity
- Autoimmunity to CD38 and GAD in Type I and Type II diabetes: CD38 and HLA genotypes and clinical phenotypes
- Characterization of a naturally occurring mutation (L107I) in the HNF1 alpha (MODY3) gene.
- Contribution of known and unknown susceptibility genes to early-onset diabetes in scandinavia: evidence for heterogeneity.
- Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistance
- Down-regulation of insulin receptor substrates (IRS)-1 and IRS-2 and Src homologous and collagen-like protein Shc gene expression by insulin in skeletal muscle is not associated with insulin resistance or type 2 diabetes.
- FOXC2 mRNA Expression and a 5' Untranslated Region Polymorphism of the Gene Are Associated With Insulin Resistance.
- Fallbeskrivning. Rosiglitazonbehandling gav kraftfull effekt, men fick ändå avbrytas
- Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: the Botnia study.
- Glutamic acid decarboxylase antibody positivity is associated with an impaired insulin response to glucose and arginine in nondiabetic patients with autoimmune thyroiditis
- Nateglinide Improves Early Insulin Secretion and Controls Postprandial Glucose Excursions in a Prediabetic Population.
- Onset of glucose intolerance in MODY3 Pro291fsInsC mutation carrierscoincides with pubertal years - a prospective follow-up study
- Plasma ProANP(1-30) reflects salt sensitivity in subjects with heredity for hypertension
- Polymorphism in the Calpain 10 gene influences glucose metabolism in human fat cells
- Screening for MODY mutations, GAD antibodies, and type 1 diabetes--associated HLA genotypes in women with gestational diabetes mellitus.
- The genetic abnormality in the beta cell determines the response to an oral glucose load
- The hormone-sensitive lipase C-60G gene polymorphism is associated with abdominal obesity
- The prevalence of polymorphisms in the interleukin-1 gene in a group of patients with recurrent periodontal disease.
- Variants in the calpain-10 gene predispose to insulin resistance and elevated free fatty acid levels.
- 2001
- A gene conferring susceptibility to type 2 diabetes in conjunction with obesity is located on chromosome 18p11
- An automated fluorescent single strand conformation polymorphism technique for high throughput mutation screening
- Assessment of beta-cell function during the oral glucose tolerance test by a minimal model of insulin secretion
- Beta(2)-adrenergic receptor gene variation and hypertension in subjects with type 2 diabetes
- Cardiovascular morbidity and mortality associated with the metabolic syndrome
- Characterization of the annexin I gene and evaluation of its role in type 2 diabetes
- Common variants in the beta2-(Gln27Glu) and beta3-(Trp64Arg)--adrenoceptor genes are associated with elevated serum NEFA concentrations and type II diabetes
- Differential phosphorylation of Janus kinase 2, Stat5A and Stat5B in response to growth hormone in primary rat adipocytes
- Functional consequences of mutations in the MODY4 gene (IPF1) and coexistence with MODY3 mutations
- Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height
- Hypothalamic-pituitary-adrenal response to different tests in type 1 diabetes mellitus
- Inhibition of the rise in FFA by Acipimox partially prevents GH-induced insulin resistance in GH-deficient adults
- Linkage disequilibrium at PPARG and other genes assessed with dense sets of SNPs.
- Metabolic effects of metformin in patients with impaired glucose tolerance
- Metabolic impact of a family history of Type 2 diabetes. Results from a European multicentre study (EGIR)
- Polymorphism in the beta(1)-adrenergic receptor gene and hypertension
- Possible human leukocyte antigen-mediated genetic interaction between type 1 and type 2 Diabetes
- Relationship between abdominal fat compartments and glucose and lipid metabolism in early postmenopausal women
- SR-B1 variants associated with HDL cholesterol levels in three populations
- The ACE gene I/D polymorphism is associated with higher mortality in men with hypertension and type 2 diabetes
- The dysmetabolic syndrome
- The metabolic syndrome influences the risk of chronic complications in patients with type II diabetes
- 2000
- Angiotensin converting enzyme (ACE) gene polymorphism in sarcoidosis in relation to associated autoimmune diseases
- Association between a variant in the 11 beta-hydroxysteroid dehydrogenase type 2 gene and primary hypertension
- Genetic variants of thiazide-sensitive NaCl-cotransporter in Gitelman's syndrome and primary hypertension
- Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
- Interaction between the Asn291Ser variant of the LPL gene and insulin resistance on dyslipidaemia in high risk individuals for Type 2 diabetes mellitus
- Pathogenesis of type 2 diabetes: the relative contribution of insulin resistance and impaired insulin secretion
- Role of the Gly460Trp polymorphism of the alpha-adducin gene in primary hypertension in Scandinavians
- The T 54 allele of the intestinal fatty acid-binding protein 2 is associated with a parental history of stroke
- 1999
- A paired-sibling analysis of the XbaI polymorphism in the muscle glycogen synthase gene
- Expression of naturally occurring variants in the muscle glycogen synthase gene
- Polymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes: the Skaraborg Hypertension and diabetes project
