Anna Blom

författare

• 2013
  • Analysis of genes coding for CD46, CD55 and C4b-binding protein in patients with idiopathic, recurrent, spontaneous pregnancy loss.
  • Haemophilus influenzae acquires vitronectin via the ubiquitous Protein F to subvert host innate immunity.
  • Streptococcus pneumoniae endopeptidase O (PepO): a multifunctional plasminogen and fibronectin binding protein, facilitating evasion of innate immunity and invasion of host cells.
  • Sushi domain-containing protein 4 (SUSD4) inhibits complement by disrupting the formation of the classical C3 convertase.
  • The C-type lectin of the aggrecan g3 domain activates complement.
  • The alpha(7)beta(0) Isoform of the Complement Regulator C4b-Binding Protein Induces a Semimature, Anti-Inflammatory State in Dendritic Cells
• 2012
  • A Metalloproteinase Karilysin Present in the Majority of Tannerella forsythia Isolates Inhibits All Pathways of the Complement System.
  • Acquisition of Complement Inhibitor Serine Protease Factor I and Its Cofactors C4b-Binding Protein and Factor H by Prevotella intermedia.
  • Analysis of binding sites on complement factor I using artificial N-linked glycosylation.
  • Annexin A2 and A5 serve as new ligands for C1Q on apoptotic cells.
  • Discovery and Structural Modification of 1-Phenyl-3-(1-phenylethyl)urea Derivatives as Inhibitors of Complement
  • Early Complementopathy After Multiple Injuries in Humans.
  • Effector mechanisms of anti-CD20 monoclonal antibodies in B cell malignancies.
  • Enolase of Streptococcus pneumoniae Binds Human Complement Inhibitor C4b-Binding Protein and Contributes to Complement Evasion.
  • Factor H autoantibodies and deletion of Complement Factor H-Related protein-1 in rheumatic diseases in comparison to atypical hemolytic uremic syndrome
  • Functional Recruitment of the Human Complement Inhibitor C4BP to Yersinia pseudotuberculosis Outer Membrane Protein Ail
  • Functional analyses of complement convertases using c3 and c5-depleted sera.
  • Heavy chains of inter alpha inhibitor (IαI) inhibit the human complement system at early stages of the cascade .
  • Identification of a Catalytic Exosite for Complement Component C4 on the Serine Protease Domain of C1s
  • Interactions of the complement system with molecules of extracellular matrix: Relevance for joint diseases.
  • Islet amyloid polypeptide triggers limited complement activation and binds complement inhibitor C4b-binding protein, which enhances fibril formation.
  • Multiple domains of MASP-2, an initiating complement protease, are required for interaction with its substrate C4
  • Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease.
  • Novel Scabies Mite Serpins Inhibit the Three Pathways of the Human Complement System
  • PRELP Protein Inhibits the Formation of the Complement Membrane Attack Complex
  • PRELP inhibits the formation of the complement membrane attack complex.
  • Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.
  • Serum COMP-C3b complexes in rheumatic diseases and relation to anti-TNF-alpha treatment
  • Truncated and Full-Length Thioredoxin-1 Have Opposing Activating and Inhibitory Properties for Human Complement with Relevance to Endothelial Surfaces.
• 2011
  • A Computational and Experimental Study of the Regulatory Mechanisms of the Complement System
  • Binding of Flavivirus Nonstructural Protein NS1 to C4b Binding Protein Modulates Complement Activation
  • Complement factor I in health and disease.
  • Functional Recruitment of Human Complement Inhibitor C4b-Binding Protein to Outer Membrane Protein Rck of Salmonella
  • Haemophilus influenzae Protein E Binds to the Extracellular Matrix by Concurrently Interacting With Laminin and Vitronectin
  • Haemophilus influenzae protein E recognizes the C-terminal domain of vitronectin and modulates the membrane attack complex.
  • Immune Evasion of Moraxella catarrhalis Involves Ubiquitous Surface Protein A-Dependent C3d Binding.
  • Molecular characterization of two novel cases of complete complement inhibitor Factor I deficiency.
  • Monomeric C-reactive protein modulates classic complement activation on necrotic cells
  • Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus
  • Prevalence of antibodies against Kaposi's sarcoma associated herpes virus (KSHV) complement inhibitory protein (KCP) in KSHV-related diseases and their correlation with clinical parameters.
  • Serglycin inhibits the classical and lectin pathways of complement via its glycosaminoglycan chains: Implications for multiple myeloma
  • The NC4 domain of the cartilage-specific collagen IX inhibits complement directly due to attenuation of membrane attack formation and indirectly through binding and enhancing activity of complement inhibitors C4B-binding protein and factor H.
  • The pH-regulated Antigen 1 of Candida albicans Binds the Human Complement Inhibitor C4b-binding Protein and Mediates Fungal Complement Evasion
  • The role of higher-order protein structure in supporting binding by heteroclitic monoclonal antibodies: The monoclonal antibody KIM185 to CD18 also binds C4-binding protein
• 2010
  • A recombinant vaccine effectively induces c5a-specific neutralizing antibodies and prevents arthritis.
  • Analysis of binding sites on complement Factor I that are required for its activity
  • Analysis of binding sites on complement factor I that are required for its activity.
  • Analysis of genes coding for CD46, CD55 and C4b-binding protein in patients with idiopathic, recurrent, spontaneous pregnancy loss
  • Annexin-II, DNA and histones serve as Factor H ligands on the surface of apoptotic cells.
  • Binding of the complement inhibitor C4b-binding protein to Lyme disease borreliae
  • CRASP2 of Candida albicans binds C4b-binding protein and mediates fungal contact with human endothelial cells
  • Complement inhibitor C4b-binding protein (C4BP) binding to islet amyloid polypeptide prevents complement activation and further fibril formation in the endocrine pancreas
  • Complement receptor C5aR is expressed in pancreatic islets and affects glucose-induced insulin and glucagon secretion
  • Functional recruitment of C4b-binding protein to Salmonella Rck
  • Inflammation and joint disease: Molecules/fragments that are released upon cartilage breakdown can activate complement and provide a new diagnostics for pathological complement activation
  • Inter alpha inhibitor (IaI) as novel inhibitor of human complement system
  • Ligands for C1q and factor H on the surface of apoptotic cells
  • Multiple domains of MASP-2, an initiating complement protease, are required for interaction with its substrate C4
  • Mutations in complement factor I as found in atypical hemolytic uremic syndrome lead to either altered secretion or altered function of factor I
  • Mutations in components of complement influence the outcome of Factor I-associated atypical hemolytic uremic syndrome
  • Proteases of periodontal pathogens Porphyromonas gingivalis, Tannerella forsythia and Prevotella intermedia target all pathways of the complement system
  • Regulation of Complement by Cartilage Oligomeric Matrix Protein Allows for a Novel Molecular Diagnostic Principle in Rheumatoid Arthritis
  • Regulation of complement by COMP allows for a novel molecular diagnostic principle in rheumatoid arthritis.
  • Relationships between structure and functions of a major complement inhibitor C4b-binding protein
  • The NC4 domain of the cartilage-specific collagen IX is a novel complement inhibitor
  • The interactions of thioredoxin and the complement system
  • The role of complement inhibitor C4b-binding protein in pneumococcal infection
  • UPF2 Is a Critical Regulator of Liver Development, Function and Regeneration
  • Vitronectin binds to the head region of Moraxella catarrhalis ubiquitous surface protein A2 and confers complement-inhibitory activity.
• 2009
  • C4b-binding protein (C4BP) inhibits development of experimental arthritis in mice.
  • Cartilage oligomeric matrix protein (COMP) has a dual role in complement regulation
  • Characterization of the complement inhibitory function of Rhesus rhadinovirus complement control protein (RCP).
  • Clinical isolates of Streptococcus pneumoniae bind the complement inhibitor C4b-binding protein in a PspC allele-dependent fashion.
  • Complement activation and inhibition: a delicate balance
  • Complement activation and plasma levels of C4b-binding protein in critical limb ischemia patients.
  • Complement evasion of the scabies mite Sarcoptes scabiei
  • Complement evasion strategies of pathogens-Acquisition of inhibitors and beyond.
  • Complement factors are expressed in pancreatic islets and affect glucose induced insulin secretion
  • Complement inhibitor C4b-binding protein in primary Sjögren's syndrome and its association with other disease markers.
  • Complement inhibitor C4b-binding protein interacts directly with small glycoproteins of the extracellular matrix.
  • Hypoxia increases susceptibility of non-small cell lung cancer cells to complement attack.
  • Inter alpha inhibitor (I alpha I) inhibits classical complement pathway at C1 level
  • Interpain A, a Cysteine Proteinase from Prevotella intermedia, Inhibits Complement by Degrading Complement Factor C3.
  • Ligands for factor H on the surface of apoptotic cells
  • Mutations in complement factor I as found in atypical hemolytic uremic syndrome lead either to altered secretion or altered function of factor I.
  • Nontypeable Haemophilus influenzae Protein E Binds Vitronectin and Is Important for Serum Resistance
  • Scabies mite inactivated serine protease paralogs inhibit the human complement system.
  • Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation.
  • The cartilage-specific collagen IX and its role in modulation of the complement activity
• 2008
  • Binding of complement inhibitor C4b-binding protein contributes to serum resistance of Porphyromonas gingivalis.
  • C4BP binds also to dead cells outside the blood compartment
  • C4b-binding protein in Alzheimer's disease: Binding to Abeta(1-42) and to dead cells.
  • C4b-binding protein is present in affected areas of myocardial infarction during the acute inflammatory phase and covers a larger area than C3.
  • Cellular uptake of C4b-binding protein is mediated by heparan sulfate proteoglycans and CD91/LDL receptor-related protein
  • Characterization of the complement inhibitory function of Rhesus rhadinovirus
  • Complement activation and plasma levels of C4b-binding protein in critical limb ischaemia patients
  • Contribution of interactions between complement inhibitor C4b-binding protein and pathogens to their ability to establish infection with particular emphasis on Neisseria gonorrhoeae
  • Contribution of interactions between complement inhibitor C4b-binding protein and pathogens to their ability to establish infection with particular emphasis on Neisseria gonorrhoeae.
  • Defining targets for complement components C4b and C3b on the pathogenic neisseriae
  • Effects of complement regulators bound to Escherichia coli K1 and Group B Streptococcus on the interaction with host cells
  • Generation of C4b binding protein deficient mice: Evaluation of biological functions of C4bBP in vivo
  • Haemophilus influenzae interacts with the human complement inhibitor factor H
  • Immune evasion by acquisition of complement inhibitors: The mould Aspergillus binds both factor H and C4b binding protein
  • Interaction of C4b-binding protein, factor H and C1q with different ligands on dying cells
  • Molecular and functional analysis of complement factor I mutations in atypical haemolytic uraemic syndrome patients
  • Native, amyloid fibrils and beta-oligomers of the C-terminal domain of human prion protein display differential activation of complement and bind C1q, factor H and C4b-binding protein directly.
  • Non-small cell lung cancer cells produce a functional set of complement factor I and its soluble cofactors
  • Role of complement and complement regulators in the removal of apoptotic cells
  • Scabies mite inactivated protease paralogues inhibit human complement
  • Separation of decay-accelerating and cofactor functional activities of Kaposi's sarcoma-associated herpesvirus complement control protein using monoclonal antibodies
  • Small leucine-rich repeat proteins of the extracellular matrix interact with the central core of complement inhibitor C4BP
  • Species-specificity of Neisseria gonorrhoeae infection: Do human complement regulators contribute?
  • The role of histidine rich glycoprotein in the modulation of immune function
  • Yersinia enterocolitica serum resistance proteins YadA and Ail bind the complement regulator C4b-binding protein
• 2007
  • A mutation in factor I that is associated with atypical hemolytic uremic syndrome does not affect the function of factor I in complement regulation.
  • Anguish over angiopathy: Hemolytic uremic syndrome.
  • Antibodies against Kaposi sarcoma-associated herpes virus (KSHV) complement control protein (KCP) in infected individuals
  • Biphasic Effect of Gingipains from Porphyromonas gingivalis on the Human Complement System.
  • C4b-bindingprotein and factor H compensate for the loss of membrane-bound complement inhibitors to protect apoptotic cells against excessive complement attack
  • Complement regulation in human atherosclerotic coronary lesions - Immunohistochemical evidence that C4b-binding protein negatively regulates the classical complement pathway, and that C5b-9 is formed via the alternative complement pathway
  • Endoglycosidase treatment abrogates IgG arthritogenicity: Importance of IgG glycosylation in arthritis.
  • Heptose I glycan substitutions on Neisseria gonorrhoeae lipooligosaccharide influence C4b-binding protein binding and serum resistance.
  • Interaction with C4b-binding protein contributes to nontypeable Haemophilus influenzae serum resistance.
  • Kaposi's sarcoma-associated herpes virus complement control protein: KCP - complement inhibition and more.
  • Molecular Characterization of the Interaction between Porins of Neisseria gonorrhoeae and C4b-Binding Protein.
  • Molecular characterisation of the Rhesus Rhadinovirus (RRV) ORF4 gene and the RRV complement control protein (RCP) it encodes.
  • Molecular characterization of the rhesus rhadinovirus (RRV) ORF4 gene and the RRV complement control protein it encodes
  • Rheumatoid arthritis and the complement system
  • The factor H variant associated with age-related macular degeneration (H384) and the non-disease associated form bind differentially to C-reactive protein, fibromodulin, DNA and necrotic cells.
  • Viral heparin-binding complement inhibitors--a recurring theme.
• 2006
  • Backcross and partial advanced intercross analysis of nonobese diabetic gene-mediated effects on collagen-induced arthritis reveals an interactive effect by two major loci.
  • Dissecting the regions of virion-associated Kaposi's sarcoma-associated herpesvirus complement control protein required for complement regulation and cell binding
  • Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor
  • Logarithmic phase Escherichia coli K1 efficiently avoids serum killing by promoting C4bp-mediated C3b and C4b degradation
  • Regulation of complement activation by C-reactive protein: targeting of the inhibitory activity of C4b-binding protein.
  • Relapsing fever Spirochetes Borrelia recurrentis and B. duttonii acquire complement regulators C4b-binding protein and factor H
  • The Complement Regulator C4b-Binding Protein (C4BP) Interacts with both the C4c and C4dg Subfragments of the Parent C4b Ligand: Evidence for Synergy in C4BP Subsite Binding.
  • The Kaposi's sarcoma-associated herpesvirus complement control protein (KCP) binds to heparin and cell surfaces via positively charged amino acids in CCP1-2.
• 2005
  • Activation of CD40 in cervical carcinoma cells facilitates CTL responses and augments chemotherapy-induced apoptosis
  • Binding of the complement inhibitor C4bp to serogroup B Neisseria meningitidis
  • C4b-binding protein binds to necrotic cells and DNA, limiting DNA release and inhibiting complement activation.
  • Human CO-binding protein selectively interacts with Neisseria gonorrhoeae and results in species-specific infection
  • Inhibition of coxsackie B virus infection by soluble forms of its receptors: Binding affinities, altered particle formation, and competition with cellular receptors
  • Ionic binding of C3 to the human pathogen Moraxella catarrhalis is a unique mechanism for combating innate immunity
  • Plasma bikunin: half-life and tissue uptake
  • The extracellular matrix and inflammation - Fibromodulin activates the classical pathway of complement by directly binding C1q
  • beta-Microseminoprotein binds CRISP-3 in human seminal plasma
• 2004
  • Complement inhibitor C4b-binding protein-friend or foe in the innate immune system?
  • Functions of human complement inhibitor C4b-binding protein in relation to its structure.
  • KSHV complement control protein mimics human molecular mechanisms for inhibition of the complement system.
  • Strategies developed by bacteria and virus for protection from the human complement system.
  • Structural stability and heat-induced conformational change of two complement inhibitors: C4b-binding protein and factor H.
  • The C4b-binding protein-protein S complex inhibits the phagocytosis of apoptotic cells.
  • The emerging pathogen Moraxella catarrhalis interacts with complement inhibitor C4b binding protein through ubiquitous surface proteins A1 and A2
  • The hyphal and yeast forms of Candida albicans bind the complement regulator C4b-binding
• 2003
  • C4b-binding protein (C4BP) activates B cells through the CD40 receptor
  • CCP1-4 of the C4b-binding protein alpha-chain are required for factor I mediated cleavage of complement factor C3b.
  • Effects of zinc on factor I cofactor activity of C4b-binding protein and factor H.
  • Functional activity of the complement regulator encoded by Kaposi's sarcoma associated herpesvirus.
  • Mutations in alpha-chain of C4BP that selectively affect its factor I cofactor function
  • Mutations in {alpha}-Chain of C4BP That Selectively Affect Its Factor I Cofactor Function.
  • Role of CCP2 of the C4b-binding protein beta-chain in protein S binding evaluated by mutagenesis and monoclonal antibodies.
  • The binding of protein S and the protein S-C4BP complex to neutrophils is apoptosis dependent.
• 2002
  • A Novel Interaction of Outer Membrane Protein A with C4b Binding Protein Mediates Serum Resistance of Escherichia coli K1.
  • Structural and functional studies of complement inhibitor C4b-binding protein.
  • Structural requirements for the intracellular subunit polymerization of the complement inhibitor C4b-binding protein.
  • Vitamin k-dependent protein s localizing complement regulator c4b-binding protein to the surface of apoptotic cells.
• 2001
  • Binding of C4b-binding protein: A molecular mechanism of serum resistance of Neisseria gonorrhoeae
  • Bordetella pertussis binds to human C4b-binding protein (C4BP) at a site similar to that used by the natural ligand C4b
  • C4bp binding to porin mediates stable serum resistance of Neisseria gonorrhoeae
  • Localization of a hydrophobic binding site for anticoagulant protein S on the beta -chain of complement regulator C4b-binding protein
  • Regulation of complement classical pathway by association of C4b-binding protein to the surfaces of SK-OV-3 and caov-3 ovarian adenocarcinoma cells
  • Screening the molecular surface of human anticoagulant protein C: a search for interaction sites
  • Structural and energetic characteristics of the heparin-binding site in antithrombotic protein C
  • Structural requirements for the complement regulatory activities of C4BP