Nils Wierup
Titel
Docent, Forskarassistent/Forskargruppschef
Organisation
040-391 41 4
070-378 66 24
Nils [dot] Wierup [at] med [dot] lu [dot] se
Publikationer (hämtat ur Lunds universitets publikationsdatabas)
författare
- 2013
- A link between GIP and osteopontin in adipose tissue and insulin resistance.
- Cocaine- and Amphetamine-regulated Transcript (CART) Protects Beta Cells against Glucotoxicity and Increases Cell Proliferation
- Cocaine- and amphetamine-regulated transcript is expressed in adipocytes and regulate lipid- and glucose homeostasis.
- Effects of ingestion routes on hormonal and metabolic profiles in gastric-bypassed humans
- Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes.
- 2012
- A Major Lineage of Enteroendocrine Cells Coexpress CCK, Secretin, GIP, GLP-1, PYY, and Neurotensin but Not Somatostatin.
- Expression of Cocaine- and Amphetamine-Regulated Transcript Is Associated with Worse Survival in Small Bowel Carcinoid Tumors
- Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes.
- 2011
- Biomechanical properties and innervation of the female caveolin-1-deficient detrusor.
- Cocaine- and Amphetamine-Regulated Transcript in Neuroendocrine Tumors
- Distribution of melatonin receptors in murine pancreatic islets.
- Evidence for Presence and Functional Effects of Kv1.1 Channels in beta-Cells: General Survey and Results from mceph/mceph Mice
- Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice.
- Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects.
- Pleiotropic Effects of GIP on Islet Function Involve Osteopontin
- beta-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia
- 2010
- A low glycaemic diet improves oral glucose tolerance but has no effect on β-cell function in C57BL/6J mice.
- Apelin is a novel islet peptide.
- Apelin is expressed in human and rodent islets and regulates insulin secretion
- CART is overexpressed in beta cells of diabetic mice to improve insulin secretion
- CART is upregulated in islets of type 2 diabetic patients, stimulates insulin secretion, inhibits glucagon secretion and protects against beta cell death
- Cocaine- and amphetamine-regulated transcript (CART) is upregulated in islets of type-2 diabetic patients to stimulate insulin secretion, inhibit glucagon secretion and protect against beta cell death
- Covariation of plasma ghrelin and motilin in irritable bowel syndrome.
- First Report on Metastasizing Small Bowel Carcinoids in First-Degree Relatives in Three Generations
- Growth arrest specific protein 6 (gas6) and its receptors expression and signalling in beta cells
- Increased beta-cell volume in mice fed a high-fat diet A dynamic study over 12 months
- Increased β-cell volume in mice fed a high-fat diet: A dynamic study over 12 months.
- Metabolic effects of whole grain wheat and whole grain rye in the C57BL/6J mouse.
- N-cadherin is dispensable for pancreas development but required for beta-cell granule turnover.
- Nesfatin-1 stimulates insulin secretion, inhibits glucagon secretion and is expressed in human and rodent beta cells
- Pancreatic islets of melatonin receptor knock-out mice
- Stimulation of 5-HT1a receptor decreased insulin secretion in islets of Langerhans from mice and humans
- 2009
- A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis.
- Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.
- G Protein-Coupled Receptor 39 Deficiency Is Associated with Pancreatic Islet Dysfunction
- GPR39 deficiency is associated with pancreatic islet dysfunction.
- Perilipin is present in islets of Langerhans and protects against lipotoxicity when overexpressed in the beta-cell line INS-1.
- Phosphodiesterase 3B is localized in caveolae and smooth ER in mouse hepatocytes and is important in the regulation of glucose and lipid metabolism.
- Protein GAS6 and its receptor Axl are expressed and operate in pancreatic beta cells
- 2008
- Increased metabolism in the R6/2 mouse model of Huntington's disease.
- Islet beta-cell area and hormone expression are unaltered in Huntington's disease.
- Lack of cholesterol mobilization in islets of hormone-sensitive lipase deficient mice impairs insulin secretion.
- Long-term nicotine exposure causes increased concentrations of trypsinogens and amylase in pancreatic extracts in the rat.
- 2007
- CART-peptide immunoreactivity in enteric nerves in patients with Hirschsprung's disease
- Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes
- Characterisation of CART-containing neurons and cells in the porcine pancreas, gastro-intestinal tract, adrenal and thyroid glands.
- DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide.
- Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet.
- Gastric ghrelin cell development is hampered and plasma ghrelin is reduced by delayed weaning in rats
- Ghrelin and motilin are co-secreted from a prominent endocrine cell population in the small intestine.
- Ghrelin and motilin are cosecreted from a prominent endocrine cell population in the small intestine
- Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet.
- Rat insulin promoter 2-Cre recombinase mice bred onto a pure C57BL/6J background exhibit unaltered glucose tolerance
- Rat insulin promoter 2-Cre recombinase mice bred onto a pure C57BL/6J background exhibit unaltered glucose tolerance.
- beta-cell PDE3B regulates Ca(2+)-stimulated exocytosis of insulin.
- 2006
- A Paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs.
- CART Regulates Islet Hormone Secretion and Is Expressed in the {beta}-Cells of Type 2 Diabetic Rats.
- CART is a novel islet regulatory peptide.
- Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3B.
- Inflammatory response in white adipose tissue in the non-obese hormone-sensitive lipase null mouse model.
- Neuropeptides and the regulation of islet function.
- 2005
- Antral G-cell in gastrin and gastrin-cholecystokinin knockout animals
- CART knock out mice have impaired insulin secretion and glucose intolerance, altered beta cell morphology and increased body weight
- Ghrelin and CART. Two new islet peptides. Expression, regulation and function.
- Orexin loss in Huntington's disease.
- Reduced ghrelin, IAPP and PYY expression in the stomach of gastrin-cholecystokinin knockout mice.
- The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient {beta}-cell mass and exocytosis.
- Ultrastructure of islet ghrelin cells in the human fetus.
- 2004
- Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance and deranged glucose morphology.
- Circulating levels of ghrelin in human fetuses.
- Cocaine- and Amphetamine-regulated Transcript (CART) Is Expressed in Several Islet Cell Types During Rat Development.
- Ghrelin Is Expressed in a Novel Endocrine Cell Type in Developing Rat Islets and Inhibits Insulin Secretion from INS-1 (832/13) Cells.
- Loss-of-Function Mutation of the Galanin Gene is Associated with Perturbed Islet Function in Mice.
- 2003
- 2002
