E-post: goran [dot] karlsson [at] med [dot] lu [dot] se
(hämtat ur Lunds universitets publikationsdatabas)
- Hematopoietic stem cells are regulated by Cripto, as an intermediary of HIF-1α in the hypoxic bone marrow niche.
- Human hematopoietic stem/progenitor cells overexpressing Smad4 exhibit impaired reconstitution potential in vivo.
- SPARC is dispensable for murine hematopoiesis, despite its suspected pathophysiological role in 5q- myelodysplastic syndrome.
- Cripto Regulates Hematopoietic Stem Cells as a Hypoxic-Niche-Related Factor through Cell Surface Receptor GRP78.
- High levels of the adhesion molecule CD44 on leukemic cells generate acute myeloid leukemia relapse after withdrawal of the initial transforming event.
- Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche
- SMAD4 binds HOXA9 in the cytoplasm and protects primitive hematopoietic cells against nuclear activation by HOXA9 and leukemia transformation.
- Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture.
- Cripto Selectively Expands a Distinct Population Of Hematopoietic Stem Cells Expressing Cell Surface Receptor GRP78
- Cripto Selectively Expands a Distinct Population of Hematopoietic Stem Cells Expressing the Cell Surface Receptor GRP78 and Strongly Induces An Immature Phenotype In Vivo After Ex Vivo Culture
- High Levels of the Adhesion Molecule CD44 on Leukemic Cells Generate Acute Myeloid Leukemia Relapse After Withdrawal of the Initial Transforming Event
- SMAD4 Sequestrates HOXA9 to Protect Hematopoietic Stem Cells Against Leukemia Transformation
- Complex and context dependent regulation of hematopoiesis by TGF-beta superfamily signaling.
- In an inducible model of acute myeloid leukemia, secondary hits are required to generate a leukemia relapse after removal of the initial transforming event
- SMAD4 as a therapeutic target in hoxa9-related leukemia
- A HOXA10-inducible mouse model demonstrates an important role of the initial transforming event in the maintenance of the leukemia
- A critical role for Smad4 in the self-renewal of hematopoietic stem cells
- Enforced expression of c-Ski in adult murine hematopoiesis promotes myeloid - Differentiation, revealing an important role for c-Ski in governing hematopoietic cell fate options
- Hematopoietic stem cell responsiveness to exogenous signals is limited by Caspase-3
- Signaling pathways governing stem cell fate.
- Smad4 as a Therapeutic Target in Nup98-HoxA9-Induced Leukemia.
- Stem cell regulation and host defense: the logic and the paradox.