MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia

Summary, in English

AML/GAS7, resulting from t(11;17)(q23;p13), has been reported in one case of treatment-related acute myeloid leukemia (AML). We present a de novo case of t(11;17)-positive pediatric acute lymphoblastic leukemia. Fluorescent in situ hybridization and reverse transcriptase polymerase chain reaction analyses revealed an MLL/GAS7 chimera identical to the one previously described in AML. The molecular genetic features of MLL/GAS7 and the clinical impact of t(11;17) are discussed.

• Författare: Ioannis Panagopoulos; Henrik Lilljebjörn; Bodil Strömbeck; Lars Hjorth; Tor Olofsson; Bertil Johansson
• Avdelning/ar: Avdelningen för klinisk genetik; Pediatrik, Lund; Avdelningen för hematologi och transfusionsmedicin
• Publiceringsår: 2006
• Språk: Engelska
• Sidor: 1287-1288
• Publikation/Tidskrift/Serie: Haematologica
• Volym: 91
• Issue: 9
• Länkar: http://www.haematologica.org/cgi/content/abstract/91/9/1287
• Dokumenttyp: Artikel i tidskrift
• Förlag: Ferrata Storti Foundation
• Ämne: Hematology
• Nyckelord: GAS7; MLL; ALL; translocation; fusion
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1592-8721