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Exposure to persistent organochlorine pollutants associates with human sperm Y:X chromosome ratio.

Författare

Summary, in English

BACKGROUND: During the last decades, there has been concern that exposure to endocrine disruptors, such as persistent organochlorine pollutants (POPs), may contribute to sex ratio changes in offspring of exposed populations. METHODS: To investigate whether exposure to 2,2'4,4'5,5'-hexachlorobiphenyl (CB-153) and dichlorodiphenyl dichloroethene (p,p'-DDE) affect Y:X chromosome proportion, semen of 149 Swedish fishermen, aged 27–67 years, was investigated. The men provided semen and blood for analysis of hormone, CB-153 and p,p'-DDE levels. The proportion of Y- and X-chromosome bearing sperm in semen samples was determined by two-colour fluorescence in situ hybridization (FISH) analysis. RESULTS: Log transformed CB-153 as well as log transformed p,p'-DDE variables were both significantly positively associated with Y chromosome fractions (P-values=0.05 and <0.001, respectively). Neither age, smoking nor hormone levels showed any association with Y-chromosome fractions. CONCLUSIONS: This is the first study to indicate that exposure to POPs may increase the proportion of ejaculated Y-bearing spermatozoa. These data add to the growing body of evidence that exposure to POPs may alter the offspring sex ratio.

Publiceringsår

2005

Språk

Engelska

Sidor

1903-1909

Publikation/Tidskrift/Serie

Human Reproduction

Volym

20

Issue

7

Dokumenttyp

Artikel i tidskrift

Förlag

Oxford University Press

Ämne

  • Clinical Medicine

Nyckelord

  • polychlorinated biphenyls/POP/p
  • p'-DDE/sex ratio/sperm

Status

Published

Forskningsgrupp

  • Reproductive medicine, Malmö
  • Molecular genetic reproductive medicine, Malmö

ISBN/ISSN/Övrigt

  • ISSN: 0268-1161