Buserelin treatment to rats causes enteric neurodegeneration with moderate effects on CRF-immunoreactive neurons and Enterobacteriaceae in colon, and in acetylcholine-mediated permeability in ileum.
Författare
Summary, in English
The gonadotropin-releasing hormone (GnRH) analog buserelin causes enteric neuronal loss. Acute stress or injection of corticotropin-releasing factor (CRF) affects motility, secretion, and barrier function of the gastrointestinal tract. The aim of the study was to characterize the CRF immunoreactivity in enteric neurons after buserelin treatment, and to evaluate possible effects of enteric neuropathy on gut microbiota, intestinal permeability, and stress response behavior.
Avdelning/ar
- Neurogastroenterology
- Avdelningen för livsmedel och läkemedel
- Klinisk koagulationsmedicin, Malmö
- Gastroenterologi
- Chronic Inflammatory and Degenerative Diseases Research Unit
- Internmedicin - epidemiologi
Publiceringsår
2015
Språk
Engelska
Publikation/Tidskrift/Serie
BMC Research Notes
Volym
8
Issue
1
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
BioMed Central (BMC)
Ämne
- Gastroenterology and Hepatology
Status
Published
Forskningsgrupp
- Neurogastroenterology
- Clinical Coagulation, Malmö
- Gastroenterology
- Chronic Inflammatory and Degenerative Diseases Research Unit
- Internal Medicine - Epidemiology
ISBN/ISSN/Övrigt
- ISSN: 1756-0500