Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Do Cyclodextrins Aggregate in Water? Insights from NMR Experiments

In English

Författare

Summary, in English

One decade ago Bonini et al. [Langmuir 2006, 22, 1478-1484] reported the occurrence of aggregates of beta-cyclodextrin in aqueous Solutions with sizes in the range from 90 nm to a few micrometers. The experimental technique used was cryo-TEM. This work followed a number of previous studies involving other physical parameters, such as viscosities and activity coefficients, the results of which were interpreted in terms of self-aggregation of cydodextrins. Since then, the ability of cyclodextrins to self-assemble were often used to explain and rationalize the supramolecular mechanisms involving cydodextrins. Here, the question of aggregation of native cyclodextrins (alpha-, beta-, and gamma-) in aqueous solutions is addressed by using H-1 NMR techniques, including NMR diffusometry, relaxometry, and proton peak intensities. Within the detection limit of the NMR experiments, no aggregates of cyclodextrin were observed. If aggregates are present, the fraction of cyclodextrin in aggregates is quite small less than 1%. However, we cannot exclude the presence of transient clusters involving several cyclodextrin molecules where the lifetime Of the cluster is short.

Avdelning/ar

Publiceringsår

2015

Språk

Engelska

Sidor

6314-6320

Publikation/Tidskrift/Serie

Langmuir

Volym

31

Issue

23

Dokumenttyp

Artikel i tidskrift

Förlag

The American Chemical Society (ACS)

Ämne

  • Physical Chemistry

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0743-7463