Synthesis of the Bioactive Benzochromenes Pulchrol and Pulchral, Metabolites of Bourreria pulchra

Summary, in English

The parasites Leshmania mexicana and Trypanosoma cruzi cause serious health problems, and few efficient treatments are available. Recently, the two benzochromenes pulchrol (1) and pulchral (2) were reported from the roots of Bourreria pulchra, and especially 1 but also 2 was found to be active towards the parasites. In this paper, we present a total synthesis of 1 and 2 to facilitate their biological evaluation. The synthesis is mild, short, and high yielding and suitable for a structure-activity relationship study.

• Författare: Dan Killander; Olov Sterner
• Avdelning/ar: Centrum för analys och syntes
• Publiceringsår: 2014
• Språk: Engelska
• Sidor: 1594-1596
• Publikation/Tidskrift/Serie: European Journal of Organic Chemistry
• Volym: 2014
• Issue: 8
• Länkar: http://dx.doi.org/10.1002/ejoc.201301792
• Dokumenttyp: Artikel i tidskrift
• Förlag: John Wiley & Sons Inc.
• Ämne: Chemical Sciences
• Nyckelord: Total synthesis; Natural products; Bioactive metabolites; Cross-coupling; Oxygen heterocycles
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1434-193X