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Viral vector-mediated overexpression of α-synuclein as a progressive model of Parkinson's disease

In English

Författare

Summary, in English

The discovery of the role of α-synuclein in the pathogenesis of Parkinson's disease (PD) has opened new possibilities for the development of more authentic models of Parkinson's disease. Recombinant adeno-associated virus (AAV) and lentivirus (LV) vectors are efficient tools for expression of genes locally in subsets of neurons in the brain and can be used to express human wild-type or mutated α-synuclein selectively in midbrain dopamine neurons. Using this approach, it is possible to trigger extensive PD-like cellular and axonal pathologies in the nigrostriatal projection, involving abnormal protein aggregation, neuronal dysfunction, and cell death that develop progressively over time. Targeted overexpression of human α-synuclein in midbrain dopamine neurons, using AAV vectors, reproduces many of the characteristic features of the human disease and provides, for the first time, a model of progressive PD that can be applied to both rodents and primates.

Publiceringsår

2010

Språk

Engelska

Sidor

89-111

Publikation/Tidskrift/Serie

Progress in Brain Research

Volym

184

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Neurosciences

Nyckelord

  • Synuclein
  • Dopamine
  • Nigrostriatal system
  • Motor impairment
  • Adeno-associated virus
  • Lentivirus
  • Viral vectors
  • Animal models

Status

Published

Forskningsgrupp

  • Brain Repair and Imaging in Neural Systems (BRAINS)
  • Neurobiology

ISBN/ISSN/Övrigt

  • ISSN: 1875-7855