Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells.
Författare
Summary, in English
T follicular helper (Tfh) cells represent a recently defined CD4(+) T cell subset characterized by the expression of the chemokine receptor CXCR5 and an enhanced ability to support B cells to mount antibody responses. Here, we demonstrate that lymph-node-resident CXCR5(+) Tfh cells and gut-homing integrin alpha(4)beta(7)-expressing T helper cells are generated as separate subsets in the gut-draining mesenteric lymph nodes. Type I interferon signaling in dendritic cells and in nonhematopoietic cells selectively stimulates Tfh cell development in response to antigen in conjunction with Toll-like receptor (TLR)3 or TLR4 agonists. Consistent with this, the ability of dendritic cells to produce the cytokine IL-6, required for in vivo Tfh differentiation, and antibody affinity maturation are both reduced in absence of type I interferon signaling. Thus, our results identify type I interferon as a natural adjuvant that selectively supports the generation of lymph node resident Tfh cells.
Avdelning/ar
- Immunology
Publiceringsår
2009
Språk
Engelska
Sidor
491-501
Publikation/Tidskrift/Serie
Immunity
Volym
31
Issue
3
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Cell Press
Ämne
- Immunology in the medical area
Nyckelord
- Helper-Inducer: metabolism
- T-Lymphocytes
- Receptor
- Interferon alpha-beta: immunology
- Receptors
- CXCR5: metabolism
- Helper-Inducer: cytology
- Helper-Inducer: immunology
- Interferon alpha-beta: genetics
- Interferon alpha-beta: deficiency
- Lymph Nodes: metabolism
- Lymph Nodes: immunology
- Lymph Nodes: cytology
- Interleukin-6: biosynthesis
- Interferon Type I: immunology
- Integrins: metabolism
- CD11c: immunology
- Antigens
- Dendritic Cells: immunology
Status
Published
Forskningsgrupp
- Immunology
ISBN/ISSN/Övrigt
- ISSN: 1074-7613