Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease.

Summary, in English

To evaluate whether cytokines are altered in peripheral blood of rats transgenic for the human Huntington´s disease mutation we investigated serum levels of GRO/KC, IL-1β, IL-13 and TNF-α at a symptomatic stage at 12 months of age. Overall serum levels of these cytokines were not significantly changed between transgenic HD rats and controls. Moreover, we observed a high interindividual variability. Our results indicate that these cytokines will be difficult to pursue as biomarkers in at least this rat model of HD.

• Författare: Huu Phuc Nguyen; Maria Björkqvist; Felix J Bode; Michael Stephan; Stephan von Hörsten
• Avdelning/ar: Institutionen för experimentell medicinsk vetenskap; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publiceringsår: 2010
• Språk: Engelska
• Publikation/Tidskrift/Serie: PLoS Currents
• Volym: 2
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/20981129?dopt=Abstract; http://dx.doi.org/10.1371/currents.RRN1190
• Dokumenttyp: Artikel i tidskrift
• Förlag: Public Library of Science (PLoS)
• Ämne: Neurosciences
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 2157-3999