No diagnostic value of plasma clusterin in Alzheimer's disease.

Summary, in English

There is an urgent need for biomarkers to enable early diagnosis of Alzheimer's disease (AD). It has recently been shown that a variant within the clusterin gene is associated with increased risk of AD and plasma levels of clusterin have been found to be associated with the risk of AD. We, therefore, investigated the diagnostic value of clusterin by quantifying clusterin using an ELISA in plasma from 171 controls, 127 patients with AD, 82 patients with other dementias and 30 patients with depression. We observed similar plasma clusterin levels in controls, AD patients and patients with other dementias, suggesting that plasma clusterin levels have no diagnostic value for AD. There was a slight, but significant, increase in plasma clusterin in patients with depression compared to all other groups tested, which may warrant further investigation.

• Författare: Edina Silajdzic; Lennart Minthon; Maria Björkqvist; Oskar Hansson
• Avdelning/ar: Institutionen för experimentell medicinsk vetenskap; Biomarkörer vid hjärnsjukdomar; Klinisk minnesforskning; Translationell neuroendokrinologi; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publiceringsår: 2012
• Språk: Engelska
• Publikation/Tidskrift/Serie: PLoS ONE
• Volym: 7
• Issue: 11
• Fulltext: - 234 kB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/23209684?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0050237
• Dokumenttyp: Artikel i tidskrift
• Förlag: Public Library of Science (PLoS)
• Ämne: Neurology; Basic Medicine
• Status: Published
• Forskningsgrupp: Biomarkers in Brain Disease; Clinical Memory Research; Translational Neuroendocrinology
• ISBN/ISSN/Övrigt: ISSN: 1932-6203