Evidence for a GABA-mediated cerebellar inhibition of the inferior olive in the cat

Summary, in English

1. Climbing fibres were activated by peripheral nerve stimulation at 'high' frequencies (greater than 3 Hz) for 15-25 s and then at 0.9 Hz for about 1 min. The high frequency activation induced a post-conditioning inhibition, lasting up to about 1 min, of climbing fibre responses recorded from the cerebellar surface. 2. Electrolytic lesions were made in the superior cerebellar peduncle (brachium conjunctivum). After the lesion, the post-conditioning inhibition was completely eliminated. 3. Injections of the GABA-receptor blocker bicuculline methiodide into the inferior olive reversibly blocked the post-conditioning inhibition. 4. The results support the hypothesis proposed by Andersson and Hesslow (1987a), that post-conditioning inhibition is mediated by a GABA-ergic interposito-olivary pathway.

• Författare: G Andersson; Martin Garwicz; Germund Hesslow
• Avdelning/ar: Neurofysiologi; Associativ inlärning
• Publiceringsår: 1988
• Språk: Engelska
• Sidor: 450-456
• Publikation/Tidskrift/Serie: Experimental Brain Research
• Volym: 72
• Issue: 3
• Länkar: http://dx.doi.org/10.1007/BF00250590
• Dokumenttyp: Artikel i tidskrift
• Förlag: Springer
• Ämne: Neurosciences
• Nyckelord: Cerebellum; Inferior olive; Interposito-olivary pathway; Brachium conjunctivum; GABA
• Status: Published
• Forskningsgrupp: Neurophysiology; Associative Learning
• ISBN/ISSN/Övrigt: ISSN: 0014-4819