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Expression of VEGF and VEGF Receptors in Childhood Precursor B-cell Acute Lymphoblastic Leukemia Evaluated by Immunohistochemistry.

Författare

  • Eva Diffner
  • Fredrika Gauffin
  • Lola Anagnostaki
  • Ann Nordgren
  • Bertil Gustafsson
  • Birgitta Sander
  • Britt Gustafsson
  • Jenny L Persson

Summary, in English

Perturbation in the expression and signaling pathways of vascular endothelial growth factor (VEGF) has been linked to pathogenesis of hematologic malignancies. We investigated the expression and clinical importance of VEGF and two of its receptors, VEGFR-1 and VEGFR-2, in childhood precursor B-cell acute lymphoblastic leukemia (pre-B ALL) by using immunohistochemistry. These angiogenic proteins were expressed in the majority of leukemic bone marrow samples. Notably, pre-B ALL patients had significantly increased expression of VEGFR-1 compared with no expression in the nonmalignant group, indicating a link between VEGFR-1 protein expression and pre-B ALL. These novel findings suggest that VEGFR-1 may have clinical importance in childhood pre-B ALL.

Publiceringsår

2009

Språk

Engelska

Sidor

696-701

Publikation/Tidskrift/Serie

Journal of Pediatric Hematology/Oncology

Volym

31

Dokumenttyp

Artikel i tidskrift

Förlag

Lippincott Williams & Wilkins

Ämne

  • Pediatrics

Status

Published

Forskningsgrupp

  • Pathology, Malmö
  • Experimental Cancer Research, Malmö

ISBN/ISSN/Övrigt

  • ISSN: 1536-3678