Non-alcoholic Steatohepatitis Induces a Decrease in the Levels of S-100b in the Rat Brain
Författare
Summary, in English
Using an experimental model of non-alcoholic (alimentary-induced) steatohepatitis in rats, we found that this pathological condition created by consumption of a special diet for 16 weeks results in a drop in the brain mass (by 22%, on average) and also in decreases in the size and morphological modifications of astrocytes and the level of a calcium-binding protein, S-100b. The latter shifts were greater in the hindbrain, including the cerebellum (34.8%), than in the hemispheres, including the thalamus, hypothalamus, hippocampus, and cortex (18.0%).
Avdelning/ar
Publiceringsår
2008
Språk
Engelska
Sidor
316-318
Publikation/Tidskrift/Serie
Neurophysiology
Volym
40
Issue
4
Dokumenttyp
Artikel i tidskrift
Förlag
Springer
Ämne
- Zoology
Nyckelord
- encephalopathy
- hepatic
- non-alcoholic steatohepatitis
- S-100b
- astrocytes
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0090-2977