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Phenotypic protein profiling of different B cell sub-populations using antibody CD-microarrays

Författare:
Redaktör:
  • Manfred Schwab (Dr)
Publiceringsår: 2008
Språk: Engelska
Sidor: 98-106
Publikation/Tidskrift/Serie: Cancer letters
Volym: 265
Dokumenttyp: Artikel
Förlag: Elsevier

Sammanfattning

Antibody microarrays enable extensive protein expression profiling, and provide a valuable complement to DNA microarray-based gene expression profiling. In this study, we used DotScan™ antibody microarrays that contain antibodies against 82 different cell surface antigens, to determine phenotypic protein expression profiles for human B cell sub-populations. We then demonstrated that the B cell protein profile can be used to delineate the relationship between normal B cells and malignant counterparts. Principle component analysis showed that the lymphomas did not cluster with the normal memory B cells or germinal centre B cells, but they did cluster with germinal centre founder cells and naïve B cells.

Disputation

Nyckelord

  • Biology and Life Sciences

Övrigt

Published
Yes
  • Prof. Carl AK Borrebaeck
  • ISSN: 0304-3835

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