FDG PET studies during treatment: Prediction of therapy outcome in head and neck squamous cell carcinoma.
Författare
Summary, in English
BACKGROUND: Positron emission tomography (PET) provides metabolic information of tissues in vivo. The purpose of this study was to assess the value of PET with 2-[(18) F] fluoro-2-deoxy-D-glucose (FDG) in prediction of therapy outcome (tumor response, survival, and locoregional control) in locally advanced HNSCC. METHODS: Between 1993 and 1999 47 patients underwent PET before (PET(1)) and after (PET(2)) 1 to 3 weeks of radical treatment with evaluation of metabolic rate (MR) and standardized uptake value (SUV) of FDG. All patients received radiotherapy, and 10 also received neoadjuvant chemotherapy. Median follow-up time was 3.3 years. RESULTS: Low and high MR FDG at PET(2), with median value as cutoff, was associated with complete remission in 96% and 62% (p =.007), with 5-year overall survival in 72% and 35% (p =.0042) and with local control in 96% and 55% (p =.002), respectively. CONCLUSIONS: FDG PET in the early phase of treatment of HNSCC is associated with tumor response, survival, and local control. Copyright 2002 John Wiley & Sons, Inc.
Avdelning/ar
Publiceringsår
2002
Språk
Engelska
Sidor
127-135
Publikation/Tidskrift/Serie
Head and Neck
Volym
24
Issue
2
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
John Wiley & Sons Inc.
Ämne
- Cancer and Oncology
- Otorhinolaryngology
- Radiology, Nuclear Medicine and Medical Imaging
Nyckelord
- Fludeoxyglucose F 18/*diagnostic use/pharmacokinetics
- Female
- Head and Neck Neoplasms/mortality/*radionuclide imaging/*therapy
- Human
- Male
- Middle Age
- Predictive Value of Tests
- Reproducibility of Results
- Radiopharmaceuticals/*diagnostic use/pharmacokinetics
- Squamous Cell/mortality/*radionuclide imaging/*therapy
- Carcinoma
- 80 and over
- Aged
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1043-3074