Sustained norepinephrine contraction in the rat portal vein is lost when Ca(2+) is replaced with Sr(2+).

Summary, in English

Agonist-induced activation of smooth muscle involves a rise in intracellular Ca(2+) concentration and sensitization of myosin light chain phosphorylation to Ca(2+). Sr(2+) can enter through Ca(2+) channels, be sequestered and released from sarcoplasmic reticulum, and replace Ca(2+) in activation of myosin light chain phosphorylation. Sr(2+) cannot replace Ca(2+) in facilitation of agonist-activated Ca(2+)-dependent nonselective cation channels. It is not known whether Sr(2+) can replace Ca(2+) in small G protein-mediated sensitization of phosphorylation. To explore mechanisms involved in alpha-receptor-activated contractions in smooth muscle, effects of replacing Ca(2+) with Sr(2+) were examined in rat portal vein. Norepinephrine (NE) at

• Författare: Johan Bonnevier; Ulf Malmqvist; Dagmar Sonntag; Mechthild Schroeter; Holger Nilsson; Gabriele Pfitzer; Anders Arner
• Avdelning/ar: Institutionen för experimentell medicinsk vetenskap; Avdelningen för klinisk kemi och farmakologi; Kärlfysiologi
• Publiceringsår: 2002
• Språk: Engelska
• Sidor: 845-852
• Publikation/Tidskrift/Serie: American Journal of Physiology: Cell Physiology
• Volym: 282
• Issue: 4
• Länkar: http://ajpcell.physiology.org/cgi/content/abstract/282/4/C845; http://dx.doi.org/10.1152/ajpcell.00191.2001
• Dokumenttyp: Artikel i tidskrift
• Förlag: American Physiological Society
• Ämne: Basic Medicine
• Nyckelord: Smooth; Guanosine 5'-O-(3-Thiotriphosphate)/pharmacology; Muscle; Vascular/metabolism; Norepinephrine/*pharmacology; Portal Vein/*metabolism; Potassium/pharmacology; Rats; Sprague-Dawley; Support; Strontium/*pharmacokinetics; Non-U.S. Gov't; Vasoconstrictor Agents/*pharmacology; Vasoconstriction/drug effects/physiology; Female; Calcium/*pharmacokinetics; Animal
• Status: Published
• Forskningsgrupp: Vascular Physiology
• ISBN/ISSN/Övrigt: ISSN: 1522-1563