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The genetic control of sialadenitis versus arthritis in a NOD.QxB10.Q F2 cross.

In English

Författare

  • Åsa Johansson
  • Britt Nakken
  • Martin Sundler
  • Anna-Karin Lindqvist
  • Martina Johannesson
  • Marta Alarcón-Riquelme
  • Anne Isine Bolstad
  • Michael G Humphreys-Beher
  • Roland Jonsson
  • Kathrine Skarstein
  • Rikard Holmdahl
Visa allt

Summary, in English

The non-obese diabetic (NOD) mouse spontaneously develops diabetes and sialadenitis. The sialadenitis is characterized by histopathological changes in salivary glands and functional deficit similar to Sjögren's syndrome. In humans, Sjögren's syndrome could be associated with other connective tissue disorders, such as rheumatoid arthritis. In the present study the genetic control of sialadenitis in mice was compared to that of arthritis. We have previously reported a NOD locus, identified in an F2 cross with the H2(q) congenic NOD (NOD.Q) and C57BL/10.Q (B10.Q) strains, that promoted susceptibility to collagen-induced arthritis. The sialadenitis in NOD.Q showed a similar histological phenotype as in NOD, whereas no submandibular gland infiltration was found in B10.Q. The development of sialadenitis was independent of immunization with type II collagen and established arthritis. To identify the genetic control of sialadenitis, a gene segregation experiment was performed on an (NOD.QxB10.Q)F2 cross and genetic mapping of 353 F2 mice revealed one significant locus associated with sialadenitis on chromosome 4, LOD score 4.7. The NOD.Q allele-mediated susceptibility under a recessive inheritance pattern. The genetic control of sialadenitis seemed to be unique in comparison to diabetes and arthritis, as no loci associated with these diseases have been identified at the same location.

Avdelning/ar

  • Immunology

Publiceringsår

2002

Språk

Engelska

Sidor

243-250

Publikation/Tidskrift/Serie

European Journal of Immunology

Volym

32

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Immunology in the medical area

Nyckelord

  • Chromosomes
  • Female
  • Haplotypes
  • Histocompatibility Antigens Class II : immunology
  • Male
  • Mice
  • Mice Inbred C3H
  • Mice Inbred C57BL
  • Mice Inbred NOD
  • Phenotype
  • Sialadenitis : genetics : pathology : physiopathology
  • Support Non-U.S. Gov't
  • Submandibular Gland : pathology
  • Crosses Genetic
  • Chromosome Mapping
  • Arthritis Rheumatoid : chemically induced : genetics
  • Arthritis Experimental : chemically induced : genetics
  • Animal

Status

Published

Forskningsgrupp

  • Immunology

ISBN/ISSN/Övrigt

  • ISSN: 1521-4141