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Endothelin-1 Reduces Microvascular Fluid Permeability through Secondary Release of Prostacyclin in Cat Skeletal Muscle.

In English

Författare

Summary, in English

The aim of the study was to analyze effects of various plasma concentrations of the vasoconstrictor endothelin-1 on microvascular fluid permeability and on transcapillary fluid exchange. We also analyzed whether the permeability-reducing substance prostacyclin is involved in the permeability effects of endothelin-1, as prostacylin is suggested to be released via ET(B) receptor stimulation. The study was performed on an autoperfused cat calf muscle preparation, and a capillary filtration coefficient (CFC) technique was used to estimate variations in microvascular fluid permeability (conductivity). Intraarterial infusion of endothelin-1 in low doses (5 and 10 ng/min/100 g muscle) caused transcapillary absorption, whereas higher doses (20-40 ng/min/100 g) induced filtration despite further vasoconstriction. Low-dose endothelin-1 had no significant effect on CFC, while CFC was reduced to at most 55% of baseline at higher doses (P < 0.01). Simultaneous local intraarterial infusion of the prostacyclin synthesis inhibitor tranylcypromine restored CFC to 114% of baseline (P < 0.01) and further increased vascular resistance. A low, nonvasodilator dose of prostacyclin given intravenously counteracted the tranylcypromine effect on CFC. The decreased CFC induced by a high dose of endothelin-1 was counteracted by the ET(B) receptor antagonist BQ-788 with no change in vascular resistance (P < 0.05). We conclude that the decreased CFC following high doses of endothelin-1 can be attributed to a decrease in microvascular hydraulic conductivity, mediated by secondary release of prostacylin via stimulation of the ET(B) receptor. Endothelin-1 may induce edema through postcapillary vasoconstriction. (c)2001 Elsevier Science.

Publiceringsår

2002

Språk

Engelska

Sidor

50-60

Publikation/Tidskrift/Serie

Microvascular Research

Volym

63

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Academic Press

Ämne

  • Basic Medicine

Nyckelord

  • Epoprostenol : antagonists & inhibitors : metabolism
  • Male
  • Microcirculation : metabolism
  • Muscle Skeletal : cytology : metabolism
  • Receptors Endothelin metabolism
  • Support Non-U.S. Gov't
  • Tranylcypromine : pharmacology
  • Time Factors
  • Endothelin-1 : biosynthesis
  • Dose-Response Relationship Drug
  • Cats
  • Capillary Permeability
  • Arteries : metabolism
  • Capillaries : metabolism
  • Animal

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1095-9319