Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Proteolysis and its regulation at the surface of Streptococcus pyogenes.

In English

Författare

Summary, in English

Pathogenic bacteria often produce proteinases that are believed to be involved in virulence. Moreover, several host defence systems depend on proteolysis, demonstrating that proteolysis and its regulation play an important role during bacterial infections. Here, we discuss how proteolytical events are regulated at the surface of Streptococcus pyogenes during infection with this important human pathogen. Streptococcus pyogenes produces proteinases, and host proteinases are produced and released as a result of the infection. Streptococcus pyogenes also recruits host proteinase inhibitors to its surface, suggesting that proteolysis is tightly regulated at the bacterial surface. We propose that the initial phase of a S. pyogenes infection is characterized by inhibition of proteolysis and complement activity at the bacterial surface. This is achieved mainly through binding of host proteinase inhibitors and complement regulatory proteins to bacterial surface proteins. In a later phase of the infection, massive proteolytic activity will release bacterial surface proteins and degrade human tissues, thus facilitating bacterial spread. These proteolytic events are regulated both temporally and spatially, and should influence virulence and the outcome of S. pyogenes infections.

Avdelning/ar

Publiceringsår

2002

Språk

Engelska

Sidor

537-544

Publikation/Tidskrift/Serie

Molecular Microbiology

Volym

43

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

Wiley-Blackwell

Ämne

  • Infectious Medicine

Nyckelord

  • Complement Activation
  • Cell Membrane : metabolism
  • Enzymes : metabolism
  • Human
  • Streptococcal Infections : metabolism
  • Plasmin : metabolism
  • Streptococcal Infections : microbiology
  • Streptococcus pyogenes : metabolism
  • Streptococcus pyogenes : pathogenicity
  • Support
  • Non-U.S. Gov't
  • Bacterial Proteins : metabolism

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1365-2958