Cytogenetic abnormalities in a hemangiopericytoma of the spleen.

Summary, in English

To date, only 16 cytogenetically abnormal hemangiopericytomas (HP) have been reported. Despite this low number, some characteristic karyotypic features have already emerged: most HP are near-diploid and breakpoints in 12q13, 12q24, and 19q13 seem to be common, with t(12;19)(q13;q13) being a recurrent translocation. Here, we report the first case of a probably benign splenic HP with chromosomal abnormalities. The abnormal karyotype was 47,XX,t(5;22;11)(q31;q11;q13),+10. None of these abnormalities have previously been reported in HP, suggesting that the karyotypic pattern of splenic HP may differ from soft tissue HP.

• Författare: Magnus Hallén; Luis A Parada; Ludmila Gorunova; Birger Pålsson; Michael Dictor; Bertil Johansson
• Avdelning/ar: Kirurgi, Lund; Avdelningen för klinisk genetik; Kirurgi; Tumörmikromiljö
• Publiceringsår: 2002
• Språk: Engelska
• Sidor: 62-65
• Publikation/Tidskrift/Serie: Cancer Genetics and Cytogenetics
• Volym: 136
• Issue: 1
• Länkar: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12165454&dopt=Abstract; http://dx.doi.org/10.1016/S0165-4608(01)00664-1
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Surgery; Medical Genetics; Cancer and Oncology
• Nyckelord: Male; Karyotyping; Immunohistochemistry; Human; Hemangiopericytoma : genetics; Female; Cytogenetic Analysis; Case Report; Chromosome Aberrations; Splenic Neoplasms : genetics
• Status: Published
• Forskningsgrupp: Surgery
• ISBN/ISSN/Övrigt: ISSN: 0165-4608