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Effects of leukocyte and fibroblast interferon on events in the fibroblast cell cycle

In English

Författare

  • E Lundgren
  • I Larsson
  • Håkan Miörner
  • O Strannegard

Summary, in English

Serum-depleted human foetal skin fibroblasts were stimulated by addition of 10% foetal calf serum to proliferate synchronously for at least one cell cycle. This proliferation was suppressed by leukocyte or fibroblast interferon (IF), which prolonged the G1 phase and diminished the rate of DNA synthesis during the S phase in a dose-dependent manner. When used in identical concentration, as judged in terms of units of antiviral activity, fibroblast IF had more pronounced effects on cell cycle events than leukocyte IF. Interferon exerted its effect in early G1, before the cells were irreversibly committed to DNA synthesis.

Publiceringsår

1979

Språk

Engelska

Sidor

589-595

Publikation/Tidskrift/Serie

Journal of General Virology

Volym

42

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

Microbiology Society

Ämne

  • Microbiology in the medical area

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1465-2099