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Reduced colonization of newborns with group B streptococci following washing of the birth canal with chlorhexidine

In English

Författare

Summary, in English

Possible measures for prevention of neonatal group B streptococcal (GBS) septicemia include active or passiv immunoprophylaxis and administration of penicillin to mothers and infants. In a previous study we have found GBS to be extremely sensitive to chlorhexidine. Furthermore vaginal washing with chlorhexidine diminished the recovery of GBS from parturients. In order to study the effect of chlorhexidine washing upon the colonization of newborns, a study group of chronic GBS carriers, i.e. women who were GBS positive in the 32-36 gestational week as well as during labor was selected. In 18 of these females chlorhexidine washing was performed prior to delivery while 33 chronic carriers served as controls. Screening during labor was performed in 945 consecutive patients. Cultures were collected from the external ear, throat and umbilicus of all infants within 5 minutes of birth and at day 4 of life. At birth 22% of the infants of the chlorhexidine washed mothers were colonized with GBS, in contrast to 52% of the infants from the chronic GBS carriers (p less than 0.05). The proportion of infants harboring GBS at day 4 were similar in the two groups (Tab. I). Among the 945 consecutively screened women, 164 harbored GBS and 54 (33%) of their 164 infants were colonized at birth. The colonization rate of the infants from chronic GBS carriers was significantly higher, 17 of 33 infants (p less than 0.05). This may reflect that the risk of contracting GBS by infants increases with the quantity of GBS in the birth channel.

Publiceringsår

1985

Språk

Engelska

Sidor

239-243

Publikation/Tidskrift/Serie

Journal of Perinatal Medicine

Volym

13

Issue

5

Dokumenttyp

Artikel i tidskrift

Förlag

De Gruyter

Ämne

  • Pediatrics

Status

Published

Forskningsgrupp

  • Child and Family Health

ISBN/ISSN/Övrigt

  • ISSN: 1619-3997