Reciprocal translocation (11;19)(q23;p13) in congenital acute lymphoblastic leukemia
Författare
Summary, in English
The cytogenetic, clinical, and immunologic findings ina 4-month-old girl with acute lymphoblastic leukemia (ALL) are reported. The malignant lymphoblasts were characterized cytogenetically by the reciprocal translocation t(11;19)(q23;p13); immunologically by an immature pre-B-ALL phenotype. In spite of the high-risk nature of the leukemia, the patient attained complete remission relatively quickly and is still free of disease 3 years after diagnosis. Because the only two previously reported ALL patients with t(11;19) also seem to have responded well to therapy, this cytogenetic abnormality might turn out to be an indicator of favorable prognosis in ALL.
Avdelning/ar
Publiceringsår
1986
Språk
Engelska
Sidor
239-244
Publikation/Tidskrift/Serie
Cancer Genetics and Cytogenetics
Volym
23
Issue
3
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Pediatrics
- Medical Genetics
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0165-4608