Distribution of different fibre types in human skeletal muscles: a method for the detection of neurogenic disorders
Författare
Summary, in English
Human skeletal muscles are composed of two distinguishable types of fibres, which in healthy muscles appear to be randomly arranged. Large groups of one fibre type are commonly regarded as evidence of a neuropathological process affecting the peripheral nerves or the nerve cells in the spinal cord. An objective method that detects non-random arrangements as a sign of a neurogenic disorder, particularly in its early stages, could improve diagnosis. The randomness, or otherwise, of the fibre type arrangement is here considered in terms of the numbers of fibres surrounded entirely by others of the same type (enclosed fibres). The distribution of the number of enclosed fibres is studied for a free-sampling model using Monte Carlo methods. The negative binomial distribution is shown to fit closely, where the parameters can be expressed in terms of the number of fibres and the fibre type proportion in a sample area. This result permits the calculation of significance levels for a sample area and the combination of information in several sample areas. Finally, the method is applied to whole cross-sections of 24 male human autopsied muscles.
Publiceringsår
1987
Språk
Engelska
Sidor
81-91
Publikation/Tidskrift/Serie
IMA Journal of Mathematics Applied in Medicine and Biology
Volym
4
Issue
1
Dokumenttyp
Artikel i tidskrift
Förlag
Oxford University Press
Ämne
- Neurology
- Surgery
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0265-0746