Origins of substance P- and calcitonin gene-related peptide-containing nerves in the internal carotid artery of rat

Summary, in English

An aggregation of substance P (SP)- and calcitonin gene-related peptide (CGRP)-containing nerve cells (internal carotid mini-ganglion) is described at the junction between the greater superficial petrosal nerve and the internal carotid nerve close to the internal carotid artery. A retrograde tracer dye technique demonstrates that this ganglion and the trigeminal and superior vagal ganglia supply the internal carotid artery with SP/CGRP fibers at, above and below this level, respectively. Implications of this finding for cranial painful syndromes in man are discussed.

• Författare: Jan Erik Hardebo; Norihiro Suzuki; Christer Owman
• Avdelning/ar: Neurologi, Lund; Drug Target Discovery
• Publiceringsår: 1989
• Språk: Engelska
• Sidor: 39-45
• Publikation/Tidskrift/Serie: Neuroscience Letters
• Volym: 101
• Issue: 1
• Länkar: http://dx.doi.org/10.1016/0304-3940(89)90437-0
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Neurosciences
• Nyckelord: Sensory nerve fiber; Sensory ganglia; Peptide; Substance P; Calcitonin gene-related peptide; Immunohistochemistry
• Status: Published
• Forskningsgrupp: Drug Target Discovery
• ISBN/ISSN/Övrigt: ISSN: 0304-3940