Pyridoxine reduces cholesterol and low-density lipoprotein and increases antithrombin III activity in 80-year-old men with low plasma pyridoxal 5-phosphate

Summary, in English

We have previously observed that pyridoxine treatment reduced plasma total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol concentrations and increased antithrombin III (AT III) activity in atherosclerotic patients with subnormal plasma pyridoxal 5-phosphate (PLP) levels. In order to confirm these results, we selected 17 males with low plasma PLP levels from a group of 122 80-year-old males in whom PLP has been determined. After supplementation with 120 mg of pyridoxine per day for 8 weeks their mean plasma TC and LDL cholesterol concentrations were decreased by 10% (p less than 0.01) and 17% (p less than 0.001), respectively. There was no effect on high-density lipoprotein cholesterol and triglycerides but plasma AT III activity was increased by 6% (p less than 0.05). The mechanism by which pyridoxine acts is unclear but it is hypothesized that pyridoxine-derived PLP may enhance the catabolism of LDL and the activity of AT III by inhibiting their glycosylation.

• Författare: L Brattström; L. Stavenow; H Galvard; P Nilsson-Ehle; E Berntorp; P Jerntorp; S Elmståhl; H Pessah-Rasmussen
• Avdelning/ar: Geriatric Medicine; Avdelningen för klinisk kemi och farmakologi; Klinisk koagulationsmedicin, Malmö; Rehabiliteringsmedicin; Stroke policy och kvalitetsregisterforskning; Neurologi, Lund
• Publiceringsår: 1990-12
• Språk: Engelska
• Sidor: 873-877
• Publikation/Tidskrift/Serie: Scandinavian Journal of Clinical & Laboratory Investigation
• Volym: 50
• Issue: 8
• Länkar: http://dx.doi.org/10.3109/00365519009104955
• Dokumenttyp: Artikel i tidskrift
• Förlag: Informa Healthcare
• Ämne: Gerontology, specializing in Medical and Health Sciences; Pharmacology and Toxicology; Cardiac and Cardiovascular Systems; Neurology; Medicinal Chemistry
• Nyckelord: cholesterol; pyridoxal 5-phosphate; antithrombin III; pyridoxine; low-density lipoproteins
• Status: Published
• Forskningsgrupp: Geriatric Medicine; Clinical Coagulation, Malmö; Rehabilitation medicine; Stroke policy and quality register research
• ISBN/ISSN/Övrigt: ISSN: 1502-7686