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Peripheral serotonergic markers in patients with suicidal behavior

In English

Författare

Summary, in English

Peripheral serotonergic parameters were studied in 17 patients with a history of suicidal behavior and in 17 age- and sex-matched healthy controls. Serotonin2 receptor function in platelets, measured as serotonin-induced [32P]phosphatidylinositol 4,5-bisphosphate hydrolysis, was significantly higher in patients than in age- and sex-matched controls. Increased serotonin2 receptor transduction was not correlated to psychiatric diagnosis, drug treatment or a history of violent suicide attempt. Monoamine oxidase activity was lower in platelets from patients with a history of suicidal behavior than in controls. In addition, whole blood serotonin was analyzed but no significant alterations were found in blood from patients.

Publiceringsår

1991

Språk

Engelska

Sidor

503-510

Publikation/Tidskrift/Serie

European Neuropsychopharmacology

Volym

1

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Psychiatry
  • Pharmacology and Toxicology

Nyckelord

  • Suicide
  • Phosphatidylinositol 4
  • 5-bisphosphate
  • Serotonin
  • Serotonin2 receptors
  • Monoamine oxidase
  • Phospholipase C
  • Platelets
  • Blood

Status

Published

Forskningsgrupp

  • Clinical Chemistry, Malmö

ISBN/ISSN/Övrigt

  • ISSN: 1873-7862