Adaptation of signal transduction in brain

Summary, in English

Cell culture models were used to study the effects of long-term ethanol exposure on neuronal cells. Effects on phospholipase C and phospholipase D mediated signal transduction were investigated by assaying receptor-binding, G protein function, activities of lipases, formation of second messengers and c-fos mRNA. The signal transduction cascades displayed abnormal activities from 2 to 7 days of exposure which differed from the acute effects. Phosphatidylethanol formed by phospholipase D is an abnormal lipid that may harmfully affect nerve cell function.

• Författare: Christer Alling; L Gustavsson; Christer Larsson; C Lundqvist; D Rodriguez; Per Simonsson
• Avdelning/ar: Avdelningen för klinisk kemi och farmakologi; Institutionen för translationell medicin; Klinisk kemi, Malmö
• Publiceringsår: 1994
• Språk: Engelska
• Sidor: 19-28
• Publikation/Tidskrift/Serie: EXS
• Volym: 71
• Dokumenttyp: Artikel i tidskrift
• Förlag: Birkhäuser Verlag
• Ämne: Medicinal Chemistry
• Status: Published
• Forskningsgrupp: Clinical Chemistry, Malmö
• ISBN/ISSN/Övrigt: ISSN: 1023-294X