Localization of hormone-sensitive lipase to rat Sertoli cells and its expression in developing and degenerating testes
Författare
Summary, in English
Using in situ hybridization, hormone-sensitive lipase was found to be expressed in a stage-dependent manner in Sertoli cells of rat testis. No expression was found in Leydig cells but expression in spermatids could not be excluded. These results suggest a role for hormone-sensitive lipase in the metabolism of lipid droplets in Sertoli cells, in contrast to its previously proposed function in steroid biosynthesis. The expression of testicular hormone-sensitive lipase mRNA and protein, both larger in size compared to other tissues, coincided with the onset of spermatogenesis and was dependent on scrotal localization of the testis, suggesting a temperature-dependent, pretranslational regulation of expression.
Avdelning/ar
Publiceringsår
1994
Språk
Engelska
Sidor
125-130
Publikation/Tidskrift/Serie
FEBS Letters
Volym
355
Issue
2
Dokumenttyp
Artikel i tidskrift
Förlag
Wiley-Blackwell
Ämne
- Biological Sciences
Nyckelord
- Hormone sensitive lipase
- Cholesterol ester hydrolase
- Testis
- Sertoli cell
- In situ hybridization
Status
Published
Forskningsgrupp
- Insulin Signal Transduction
- Molecular Endocrinology
ISBN/ISSN/Övrigt
- ISSN: 1873-3468