Copolymers of 1,5-dioxepan-2-one and L- or D,L-dilactide: in vivo degradation behaviour
Författare
Summary, in English
Copolymers of 1,5-dioxepan-2-one (DXO) and L- or D,L-dilactide have been synthesized and characterized. The molar ratio of the two monomers was around 20/80 of DXO and L- or D,L-lactide respectively. In vivo studies on rats revealed significant differences in tissue response between the semicrystalline DXO/L-LA copolymer and the amorphous DXO/D,L-LA copolymer. The materials were characterized pre- and post-implantation by size-exclusion chromatography (SEC), differential scanning calorimetry (DSC), nuclear magnetic resonance (NMR), and light-microscopy. Degradation seems to follow an autocatalytic hydrolysis mechanism. The amorphous copolymer was degraded at a faster rate and gave a less pronounced foreign body reaction as compared to the semicrystalline one.
Publiceringsår
1994
Språk
Engelska
Sidor
411-423
Publikation/Tidskrift/Serie
Journal of Biomaterials Science. Polymer Edition
Volym
6
Issue
5
Dokumenttyp
Artikel i tidskrift
Förlag
VSP BV
Ämne
- Medical Biotechnology
Nyckelord
- Degradation
- In vivo
- copolymers
- polyesters
- aliphatic
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0920-5063