Combined alpha-interferon and ribavirin treatment in chronic hepatitis C: a pilot study
Författare
Summary, in English
16 patients with chronic hepatitis C virus (HCV) infection were treated with a combination of interferon-alpha and ribavirin for 24 weeks in an open study. One patient declined further treatment due to depression after week 16 and did not complete further follow-up. A moderate decline was observed in hemoglobin and an increase in bilirubin level both reversible after discontinuing the treatment. 24 weeks after treatment cessation 9/15 (60%) evaluable patients had complete clearance of HCV-RNA as measured with PCR. HCV genotype did not seem to be correlated with response, but patients with sustained response to treatment had a significantly reduced number of HCV RNA copies/ml serum at treatment start compared with the other patients. These findings support the promising results of this combination therapy noted in other pilot studies.
Avdelning/ar
Publiceringsår
1995
Språk
Engelska
Sidor
325-329
Publikation/Tidskrift/Serie
Scandinavian Journal of Infectious Diseases
Volym
27
Issue
4
Dokumenttyp
Artikel i tidskrift
Förlag
Informa Healthcare
Ämne
- Infectious Medicine
Status
Published
Forskningsgrupp
- Clinical Microbiology, Malmö
ISBN/ISSN/Övrigt
- ISSN: 1651-1980