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Combined alpha-interferon and ribavirin treatment in chronic hepatitis C: a pilot study

Författare

  • Jean Henrik Braconier
  • Otto Paulsen
  • Katarina Engman
  • Anders Widell

Summary, in English

16 patients with chronic hepatitis C virus (HCV) infection were treated with a combination of interferon-alpha and ribavirin for 24 weeks in an open study. One patient declined further treatment due to depression after week 16 and did not complete further follow-up. A moderate decline was observed in hemoglobin and an increase in bilirubin level both reversible after discontinuing the treatment. 24 weeks after treatment cessation 9/15 (60%) evaluable patients had complete clearance of HCV-RNA as measured with PCR. HCV genotype did not seem to be correlated with response, but patients with sustained response to treatment had a significantly reduced number of HCV RNA copies/ml serum at treatment start compared with the other patients. These findings support the promising results of this combination therapy noted in other pilot studies.

Publiceringsår

1995

Språk

Engelska

Sidor

325-329

Publikation/Tidskrift/Serie

Scandinavian Journal of Infectious Diseases

Volym

27

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

Informa Healthcare

Ämne

  • Infectious Medicine

Status

Published

Forskningsgrupp

  • Clinical Microbiology, Malmö

ISBN/ISSN/Övrigt

  • ISSN: 1651-1980