Du är här

Decrease in high density lipoprotein cholesterol during prolonged storage. CELL Study Group

Författare:
Publiceringsår: 1996
Språk: Engelska
Sidor: 97-101
Publikation/Tidskrift/Serie: Scandinavian Journal of Clinical and Laboratory Investigation
Volym: 56
Nummer: 2
Dokumenttyp: Artikel
Förlag: Informa Healthcare

Sammanfattning

Different studies on the stability of high density lipoprotein cholesterol (HDL) in frozen serum or plasma have yielded conflicting results, namely increase, decrease, or no change at all during prolonged storage under freezing conditions. As part of a major trial on lipid-lowering strategies we statistically demonstrated a time-related decrease in HDL cholesterol during storage up to 46 months at -20 degrees C. We therefore re-analysed 85 frozen samples that had been analysed fresh and then stored from 26 to 46 months, using the dextran sulphate 500/Mg2+ method. A linear regression analysis of change in HDL cholesterol on time was performed. The slope was significantly negative (p < 0.0005). The regression equation was (decrease in HDL) = 0.05 - 0.008 x (time in months), i.e. after 6 months' storage at -20 degrees C there was almost a 1% decrease in the HDL cholesterol concentration per month of storage.

Disputation

Nyckelord

  • Medicine and Health Sciences
  • analysis
  • frozen specimen
  • high density lipoprotein
  • storage

Övrigt

Published
Yes
  • ISSN: 0036-5513

Box 117, 221 00 LUND
Telefon 046-222 00 00 (växel)
Telefax 046-222 47 20
lu [at] lu [dot] se

Fakturaadress: Box 188, 221 00 LUND
Organisationsnummer: 202100-3211
Om webbplatsen

LERU logo U21 logo