Molecular analysis of the O alleles at the blood group ABO locus in populations of different ethnic origin reveals novel crossing-over events and point mutations

Summary, in English

The blood group ABO genotypes of 138 group O individuals with three different ethnic origins in Brazil were determined, including Whites, Blacks and Amerindians. Several previously undescribed O alleles were found, predominantly in the Black group, in which about a third of the samples did not conform to previously known O allele structures. It has been well documented for the first time that some new alleles can arise from crossing-over events between known alleles in the ABO system. This was made possible by both restriction endonuclease analysis and direct sequencing of exons 3-7 in the ABO gene. The anticipated relatively high frequency of some of these new alleles in certain populations, necessitates great care when interpreting results from existing genotype screening methods.

• Författare: Martin L Olsson; Joao F Guerreiro; Marco A Zago; Alan Chester
• Avdelning/ar: Avdelningen för hematologi och transfusionsmedicin; Transfusionsmedicin
• Publiceringsår: 1997
• Språk: Engelska
• Sidor: 779-782
• Publikation/Tidskrift/Serie: Biochemical and Biophysical Research Communications
• Volym: 234
• Issue: 3
• Länkar: http://dx.doi.org/10.1006/bbrc.1997.6713
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Biological Sciences
• Status: Published
• Forskningsgrupp: Transfusion Medicine
• ISBN/ISSN/Övrigt: ISSN: 1090-2104